Platelet-Activating Factor Receptor (PAFR) ELISA Kit for Rabbit

Name: Rabbit PAFR ELISA Kit; Platelet-Activating Factor Receptor; MyBioSource
Brand: MyBioSource
SKU: MBS040712
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS040712

MBS040712 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Platelet-Activating Factor Receptor (PAFR) ELISA Kit target analytes in biological samples. The concentration gradients… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

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Product Overview

Online Datasheet in PDF

Product Name

Platelet-Activating Factor Receptor (PAFR), ELISA Kit

Full Product Name

Rabbit Platelet-Activating Factor Receptor ELISA Kit

Product Gene Name

PAFR elisa kit

Species Reactivity

Rabbit

Assay Type

Sandwich

Preparation and Storage

Store all reagents at 2-8 degree C

Molecular Weight

39,203 Da

Chromosome Location

Chromosome: 1; NC_000001.10 (28473677..28520447, complement). Location: 1p35-p34.3

OMIM

173393

3D Structure

ModBase 3D Structure for P25105

Other Notes

Small volumes of PAFR elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PAFR. It may not necessarily be applicable to this product.

NCBI GI #

257900493

NCBI GeneID

5724

NCBI Accession #

NP_001158195.1

UniProt Primary Accession #

P25105

UniProt Secondary Accession #

A3KMC8; A8K2H5

UniProt Related Accession #

P25105

GenBank Nucleotide #

NM_001164723.2

NCBI Official Full Name

platelet-activating factor receptor

NCBI Official Synonym Full Names

platelet-activating factor receptor

NCBI Official Symbol

PTAFR

NCBI Official Synonym Symbols

PAFR

UniProt Protein Name

Platelet-activating factor receptor

Protein Family

Platelet-activating factor receptor

UniProt Gene Name

PTAFR

UniProt Synonym Gene Names

PAFR; PAF-R; PAFr

UniProt Entry Name

PTAFR_HUMAN

NCBI Protein Information

platelet-activating factor receptor; PAF-R

NCBI Summary for PAFR

This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

UniProt Comments for PAFR

PTAFR: Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth- muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol- calcium second messenger system. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, GPCR; GPCR, family 1

Chromosomal Location of Human Ortholog: 1p35-p34.3

Cellular Component: nucleoplasm; intracellular membrane-bound organelle; membrane; integral to plasma membrane; integral to membrane; plasma membrane

Molecular Function: G-protein coupled receptor activity; platelet activating factor receptor activity; purinergic nucleotide receptor activity, G-protein coupled; lipopolysaccharide binding; phospholipid binding; lipopolysaccharide receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; phosphoinositide-mediated signaling; inositol trisphosphate biosynthetic process; cytokine and chemokine mediated signaling pathway; lipopolysaccharide-mediated signaling pathway; cytokine production; immune response; chemotaxis; inflammatory response

Research Articles on PAFR

1. Data suggest that expression of PAFR and SIRT1 (sirtuin 1) is down-regulated in endothelial progenitor cells of type 2 diabetic patients with poor glycaemic control compared to those with good glycaemic control.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with PAFR elisa kit

Products by Pathway	Pathway Diagram
Calcium Signaling Pathway antibodies	Calcium Signaling Pathway Diagram
Calcium Signaling Pathway antibodies	Calcium Signaling Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
Cytokine Signaling In Immune System Pathway antibodies	Cytokine Signaling In Immune System Pathway Diagram
G Alpha (q) Signalling Events Pathway antibodies	G Alpha (q) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
GPCRs, Class A Rhodopsin-like Pathway antibodies	GPCRs, Class A Rhodopsin-like Pathway Diagram
Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies	Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram

Diseases associated with PAFR elisa kit

Disease Name	Pubmed Publications
Fibrosis Antibodies	>2 publications with PAFR and Fibrosis
Disease Models, Animal Antibodies	>2 publications with PAFR and Disease Models, Animal
Liver Diseases Antibodies	>2 publications with PAFR and Liver Diseases
Inflammation Antibodies	>2 publications with PAFR and Inflammation
Coronary Artery Disease Antibodies	>1 publications with PAFR and Coronary Artery Disease
Arteriosclerosis Antibodies	>1 publications with PAFR and Arteriosclerosis
Myocardial Infarction Antibodies	>1 publications with PAFR and Myocardial Infarction
Atherosclerosis Antibodies	>1 publications with PAFR and Atherosclerosis

Organs/Tissues associated with PAFR elisa kit

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>5 publications with PAFR and Blood
Uterus Antibodies	>2 publications with PAFR and Uterus
Heart Antibodies	>1 publications with PAFR and Heart