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HSD17B11 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS415894

MBS415894 is an antibody targeting HSD17B11. Reactive in Human. Predicted: Mouse, Rat. Host: Rabbit. Rabbit Polyclonal Antibody More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
HSD17B11, Polyclonal Antibody
Full Product Name
Anti-HSD17B11 Antibody
Product Gene Name
anti-HSD17B11 antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human. Predicted: Mouse, Rat
Form/Format
Liquid
Purity/Purification
Affinity purified
Concentration
100ug/100ul (lot specific)
Preparation and Storage
This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Molecular Weight
32,936 Da
OMIM
612831
Storage Buffer
PBS, pH 7.4 with 0.02% Sodium Azide
Immunogen
Raised against a recombinate human HSD17B11 protein 38-254aa (BC014327)
Applications Tested/Suitable for anti-HSD17B11 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-HSD17B11 antibody
ELISA titer: 1:20,000-1:80,000
Western blot analysis: 1:500-1:1,000
Immunohistochemistry: 1:100-1:500
Optimal dilutions/concentrations should be determined by the end user

Western Blot (WB) of anti-HSD17B11 antibody

Rabbit Anti-HSD17B11 Polyclonal Antibody – Cat# MBS415894

Immunohistochemistry (IHC) #2 of anti-HSD17B11 antibody

Rabbit Anti-HSD17B11 Polyclonal Antibody, Immunohistochemistry (IHC) #2 – Cat# MBS415894

Product References and Citations for anti-HSD17B11 antibody

Persson,B., Kallberg,Y., Bray,J.E., et al. The SDR (short-chain dehydrogenase / reductase and related enzymes) nomenclature initiative. Chem. Biol. Interact. 178 (1-3), 94-98 (2009)

Other Notes

Small volumes of anti-HSD17B11 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for HSD17B11. It may not necessarily be applicable to this product.

NCBI GI #
15680028
NCBI GeneID
51170
NCBI Accession #
BC014327
UniProt Secondary Accession #
Q96HF6; Q9UKU4
UniProt Related Accession #
Q8NBQ5
NCBI Official Full Name
Homo sapiens hydroxysteroid (17-beta) dehydrogenase 11, mRNA
NCBI Official Synonym Full Names
hydroxysteroid (17-beta) dehydrogenase 11
NCBI Official Symbol
HSD17B11
NCBI Official Synonym Symbols
DHRS8; PAN1B; RETSDR2; SDR16C2; 17BHSD11; 17-BETA-HSD11; 17-BETA-HSDXI
UniProt Protein Name
Estradiol 17-beta-dehydrogenase 11
UniProt Synonym Protein Names
17-beta-hydroxysteroid dehydrogenase 11; 17-beta-HSD 11; 17bHSD11; 17betaHSD11; 17-beta-hydroxysteroid dehydrogenase XI; 17-beta-HSD XI; 17betaHSDXI; Cutaneous T-cell lymphoma-associated antigen HD-CL-03; CTCL-associated antigen HD-CL-03; Dehydrogenase/reductase SDR family member 8; Retinal short-chain dehydrogenase/reductase 2; retSDR2; Short chain dehydrogenase/reductase family 16C member 2
Protein Family
Estradiol 17 beta-dehydrogenase
UniProt Gene Name
HSD17B11
UniProt Entry Name
DHB11_HUMAN
NCBI Protein Information
estradiol 17-beta-dehydrogenase 11; 17-beta-hydroxysteroid dehydrogenase type XI; CTCL tumor antigen HD-CL-03; CTCL-associated antigen HD-CL-03; cutaneous T-cell lymphoma-associated antigen HD-CL-03; dehydrogenase/reductase SDR family member 8; retinal short-chain dehydrogenase/reductase 2; short chain dehydrogenase/reductase family 16C, member 2

NCBI Summary for HSD17B11

Short-chain alcohol dehydrogenases, such as HSD17B11, metabolize secondary alcohols and ketones (Brereton et al., 2001 [PubMed 11165019]).[supplied by OMIM, Jun 2009]

UniProt Comments for HSD17B11

HSD17B11: Can convert androstan-3-alpha,17-beta-diol (3-alpha- diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor- associated antigen in cutaneous T-cell lymphoma. Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.

Protein type: Secreted, signal peptide; EC 1.1.1.62; Oxidoreductase; Secreted

Chromosomal Location of Human Ortholog: 4q22.1

Cellular Component: cytoplasm; extracellular region; lipid particle

Molecular Function: estradiol 17-beta-dehydrogenase activity; steroid dehydrogenase activity

Biological Process: steroid biosynthetic process; androgen catabolic process
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Research Articles on HSD17B11

1. hydroxysteroid (17-beta) dehydrogenase 11 transcription in prostate cancer cells is regulated by Sp1 transcription factor and C-EBP alpha

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-HSD17B11 antibody

 Products by Pathway  Pathway Diagram
 Estradiol Biosynthesis I Pathway antibodies  Estradiol Biosynthesis I Pathway Diagram
 Superpathway Of Steroid Hormone Biosynthesis antibodies  Superpathway Of Steroid Hormone Biosynthesis Diagram

Diseases associated with anti-HSD17B11 antibody

 Disease Name  Pubmed Publications
 Hypertension Antibodies  >2 publications with HSD17B11 and Hypertension
 Prostatic Diseases Antibodies  >2 publications with HSD17B11 and Prostatic Diseases
 Neoplasms, Experimental Antibodies  >1 publications with HSD17B11 and Neoplasms, Experimental

Organs/Tissues associated with anti-HSD17B11 antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >3 publications with HSD17B11 and Lung
 Blood Antibodies  >2 publications with HSD17B11 and Blood
 Liver Antibodies  >2 publications with HSD17B11 and Liver
 Prostate Antibodies  >2 publications with HSD17B11 and Prostate
 Bone Antibodies  >1 publications with HSD17B11 and Bone
 Embryonic Tissue Antibodies  >1 publications with HSD17B11 and Embryonic Tissue
 Adipose Tissue Antibodies  >1 publications with HSD17B11 and Adipose Tissue
 Ovary Antibodies  >1 publications with HSD17B11 and Ovary
 Muscle Antibodies  >1 publications with HSD17B11 and Muscle
 Trachea Antibodies  >1 publications with HSD17B11 and Trachea
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