Rabbit Anti-ADCY2 Polyclonal Antibody – Cat# MBS415905

ADCY2 Antibody – Rabbit Polyclonal

Name: ADCY2 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS415905
Price: 335 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS415905

This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This enzyme is insensitive to Ca(2+)/calmodulin, and is… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

ADCY2, Polyclonal Antibody

Full Product Name

Anti-ADCY2 Antibody

Product Gene Name

anti-ADCY2 antibody

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Liquid

Purity/Purification

Purified

Concentration

100ug/100ul (lot specific)

Preparation and Storage

This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

Molecular Weight

103,158 Da

OMIM

103071

Storage Buffer

PBS, pH 7.4 with 0.02% Sodium Azide

Immunogen

Synthetic peptide conjugated to KLH

Applications Tested/Suitable for anti-ADCY2 antibody

Peptide ELISA (EIA), Western Blot (WB)

Application Notes for anti-ADCY2 antibody

Recommended dilutions:
Peptide ELISA: 1:160,000
WB: 1:200 - 1:1000
Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user.

Product References and Citations for anti-ADCY2 antibody

Ludwig,M.G.and Seuwen,K. Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms. J. Recept. Signal Transduct. Res. 22 (1-4), 79-110 (2002)

Other Notes

Small volumes of anti-ADCY2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ADCY2 purchase

MBS415905 is an antibody targeting ADCY2. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ADCY2. It may not necessarily be applicable to this product.

NCBI GI #

115387102

NCBI GeneID

108

NCBI Accession #

NP_065433.2

UniProt Secondary Accession #

Q2NKL8; Q9UDB2; Q9UPU2; B7Z2C1

UniProt Related Accession #

Q08462

GenBank Nucleotide #

NM_020546.2

NCBI Official Full Name

adenylate cyclase type 2

NCBI Official Synonym Full Names

adenylate cyclase 2 (brain)

NCBI Official Symbol

ADCY2

NCBI Official Synonym Symbols

AC2; HBAC2

UniProt Protein Name

Adenylate cyclase type 2

UniProt Synonym Protein Names

ATP pyrophosphate-lyase 2; Adenylate cyclase type II; Adenylyl cyclase 2

Protein Family

Adenylate cyclase

UniProt Gene Name

ADCY2

UniProt Entry Name

ADCY2_HUMAN

NCBI Protein Information

adenylate cyclase type 2; 3',5'-cyclic AMP synthetase; ATP pyrophosphate-lyase 2; adenylate cyclase II; adenylate cyclase type II; adenylyl cyclase 2; type II adenylate cyclase

UniProt Comments for ADCY2

ADCY2: This is a membrane-bound, calmodulin-insensitive adenylyl cyclase. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

Protein type: Transporter, aquaporin family; Adenylyl cyclase; Transporter; Nucleotide Metabolism - purine; EC 4.6.1.1; Lyase; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 5p15.3

Cellular Component: protein complex; membrane; cytoplasm; dendrite; integral to membrane; plasma membrane; intracellular; lipid raft

Molecular Function: protein heterodimerization activity; metal ion binding; G-protein beta/gamma-subunit binding; calcium- and calmodulin-responsive adenylate cyclase activity; ATP binding; adenylate cyclase activity; adenylate cyclase binding

Biological Process: epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; water transport; activation of protein kinase A; signal transduction; G-protein signaling, adenylate cyclase activating pathway; G-protein signaling, coupled to cAMP nucleotide second messenger; synaptic transmission; phospholipase C activation; energy reserve metabolic process; innate immune response; renal water homeostasis; cAMP biosynthetic process; G-protein signaling, adenylate cyclase inhibiting pathway; transmembrane transport

Research Articles on ADCY2

1. Our present study defines an AC2 cAMP signaling compartment that specifically regulates IL-6 expression in bronchial smooth muscle cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ADCY2 antibody

Reference Product	PubMed Publications
ADCY1 antibody	>2 publications with ADCY2 and ADCY1

Pathways associated with anti-ADCY2 antibody

Products by Pathway	Pathway Diagram
Activation Of GABAB Receptors Pathway antibodies	Activation Of GABAB Receptors Pathway Diagram
Adenylate Cyclase Activating Pathway antibodies	Adenylate Cyclase Activating Pathway Diagram
Adenylate Cyclase Inhibitory Pathway antibodies	Adenylate Cyclase Inhibitory Pathway Diagram
Adrenergic Signaling In Cardiomyocytes Pathway antibodies	Adrenergic Signaling In Cardiomyocytes Pathway Diagram
Adrenergic Signaling In Cardiomyocytes Pathway antibodies	Adrenergic Signaling In Cardiomyocytes Pathway Diagram
Aquaporin-mediated Transport Pathway antibodies	Aquaporin-mediated Transport Pathway Diagram
Bile Secretion Pathway antibodies	Bile Secretion Pathway Diagram
Bile Secretion Pathway antibodies	Bile Secretion Pathway Diagram
Ca-dependent Events Pathway antibodies	Ca-dependent Events Pathway Diagram
CaM Pathway antibodies	CaM Pathway Diagram

Diseases associated with anti-ADCY2 antibody

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>2 publications with ADCY2 and Nervous System Diseases
Neoplasm Metastasis Antibodies	>2 publications with ADCY2 and Neoplasm Metastasis
Hypertension Antibodies	>2 publications with ADCY2 and Hypertension
Immune System Diseases Antibodies	>1 publications with ADCY2 and Immune System Diseases
Lung Neoplasms Antibodies	>1 publications with ADCY2 and Lung Neoplasms
Depressive Disorder Antibodies	>1 publications with ADCY2 and Depressive Disorder
Fibrosis Antibodies	>1 publications with ADCY2 and Fibrosis
Asthma Antibodies	>1 publications with ADCY2 and Asthma

Organs/Tissues associated with anti-ADCY2 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>4 publications with ADCY2 and Brain
Lung Antibodies	>3 publications with ADCY2 and Lung
Nerve Antibodies	>2 publications with ADCY2 and Nerve
Muscle Antibodies	>2 publications with ADCY2 and Muscle
Bone Antibodies	>1 publications with ADCY2 and Bone
Skin Antibodies	>1 publications with ADCY2 and Skin
Heart Antibodies	>1 publications with ADCY2 and Heart
Intestine Antibodies	>1 publications with ADCY2 and Intestine
Embryonic Tissue Antibodies	>1 publications with ADCY2 and Embryonic Tissue