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APBA1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS416295

This gene is a member of the X11 protein family. It is a neuronal adaptor protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilises APP and inhibits production of proteolytic APP fragments including the A beta peptide… More details

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Product Overview

Product Name
APBA1, Polyclonal Antibody
Full Product Name
Anti-APBA1 Antibody
Product Gene Name
anti-APBA1 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Purity/Purification
Protein A purified
Concentration
100ug/100ul (lot specific)
Specificity
APBA1 antibody detects endogenous levels of APBA1 protein. Not tested with other proteins
Preparation and Storage
This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Molecular Weight
91,413 Da
Storage Buffer
PBS, pH 7.4 with 0.02% Sodium Azide
Immunogen
Synthetic peptide conjugated to KLH
Applications Tested/Suitable for anti-APBA1 antibody
Peptide ELISA (EIA), Western Blot (WB)
Application Notes for anti-APBA1 antibody
Recommended dilutions:
Peptide ELISA: 1:20,000
WB: 1:200 - 1:1000
Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user.

Western Blot (WB) of anti-APBA1 antibody

Rabbit Anti-APBA1 Polyclonal Antibody – Cat# MBS416295

Product References and Citations for anti-APBA1 antibody

Borg, J.P., et al. The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein.

Other Notes

Small volumes of anti-APBA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for APBA1 purchase

MBS416295 is an antibody targeting APBA1. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for APBA1. It may not necessarily be applicable to this product.

NCBI GI #
13929100
NCBI GeneID
83589
NCBI Accession #
NP_113967.1
UniProt Related Accession #
O35430
GenBank Nucleotide #
NM_031779.2
NCBI Official Full Name
amyloid beta A4 protein-binding family A member 1
NCBI Official Synonym Full Names
amyloid beta (A4) precursor protein-binding, family A, member 1
NCBI Official Symbol
Apba1
NCBI Official Synonym Symbols
Mint1
UniProt Protein Name
Amyloid beta A4 precursor protein-binding family A member 1
UniProt Synonym Protein Names
Adapter protein X11alpha; Neuron-specific X11 protein; Neuronal Munc18-1-interacting protein 1; Mint-1
Protein Family
Amyloid beta A4 precursor protein-binding family
UniProt Gene Name
Apba1
UniProt Entry Name
APBA1_RAT
NCBI Protein Information
amyloid beta A4 precursor protein-binding family A member 1; adapter protein X11alpha; amyloid beta (A4) precursor protein-binding family A APBA1: amyloid beta (A4) precursor protein-binding family A member 1 (X11); amyloid beta (A4) precursor protein-binding, family A, APBA1: amyloid beta (A4) precursor protein-binding, family A, member 1 (X11); mint-1; neuron-specific X11 protein; neuronal Munc18-1-interacting protein 1

NCBI Summary for APBA1

component of multimeric complex containing Munc18-1 and syntaxin; may mediate synaptic vesicle docking/fusion [RGD, Feb 2006]

UniProt Comments for APBA1

APBA1: Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the beta- amyloid precursor protein (APP) and hence formation of beta-APP.

Protein type: Adaptor/scaffold

Cellular Component: Golgi apparatus; protein complex; membrane; cell; perinuclear region of cytoplasm; plasma membrane; intracellular; nucleus

Molecular Function: phosphatidylinositol-4,5-bisphosphate binding; protein binding; beta-amyloid binding; protein complex binding; PDZ domain binding

Biological Process: synaptic transmission; intracellular protein transport; synaptic vesicle exocytosis; glutamate secretion; in utero embryonic development; regulation of gene expression; multicellular organism growth; gamma-aminobutyric acid secretion; locomotory behavior
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Research Articles on APBA1

1. Upon neurodegeneration with okadaic acid, mint-1 and mint-2 levels were reduced by proteolytic cleavage, and these changes were followed by increases in APP levels.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-APBA1 antibody

 Reference Product  PubMed Publications
 App antibody  >38 publications with APBA1 and App
 Cask antibody  >14 publications with APBA1 and Cask
 Psen1 antibody  >4 publications with APBA1 and Psen1
 Stxbp1 antibody  >3 publications with APBA1 and Stxbp1
 Snap25 antibody  >1 publications with APBA1 and Snap25
 Lin7b antibody  >1 publications with APBA1 and Lin7b
 Lin7a antibody  >1 publications with APBA1 and Lin7a
 Stx1a antibody  >1 publications with APBA1 and Stx1a

Diseases associated with anti-APBA1 antibody

 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >51 publications with APBA1 and Brain Diseases
 Intestinal Neoplasms Antibodies  >8 publications with APBA1 and Intestinal Neoplasms
 Death Antibodies  >6 publications with APBA1 and Death
 Inflammation Antibodies  >3 publications with APBA1 and Inflammation
 Memory Disorders Antibodies  >2 publications with APBA1 and Memory Disorders
 Cognition Disorders Antibodies  >2 publications with APBA1 and Cognition Disorders
 Hyperplasia Antibodies  >2 publications with APBA1 and Hyperplasia
 Heart Diseases Antibodies  >2 publications with APBA1 and Heart Diseases
 Seizures Antibodies  >2 publications with APBA1 and Seizures
 Adenoma Antibodies  >2 publications with APBA1 and Adenoma

Organs/Tissues associated with anti-APBA1 antibody

 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >120 publications with APBA1 and Nerve
 Brain Antibodies  >49 publications with APBA1 and Brain
 Embryonic Tissue Antibodies  >6 publications with APBA1 and Embryonic Tissue
 Pancreas Antibodies  >2 publications with APBA1 and Pancreas
 Testis Antibodies  >1 publications with APBA1 and Testis
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