IGF2R Antibody – Rabbit Polyclonal

IGF2R: a multifunctional type I transmembrane protein receptor that binds insulin-like growth factor 2 at the cell surface and mannose-6-phosphate-tagged proteins in the trans-Golgi network. Also known as the cation-independent mannose-6 phosphate (M6P) receptor. Clears IGF2 from the cell surface to attenuate signaling, and transports M6P-tagged lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. M6P-tagged lysosomal enzymes bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Belongs to the MRL1/IGF2R family.

Protein type: Receptor, misc.; Membrane protein, integral; Vesicle

Chromosomal Location of Human Ortholog: 6q26

Cellular Component: extracellular space; clathrin coat; focal adhesion; cell surface; lysosomal membrane; integral to plasma membrane; trans-Golgi network; trans-Golgi network transport vesicle; membrane; endocytic vesicle; perinuclear region of cytoplasm; nuclear envelope lumen; late endosome; endosome

Molecular Function: identical protein binding; mannose binding; retinoic acid binding; transporter activity; phosphoprotein binding; G-protein alpha-subunit binding; receptor activity; insulin-like growth factor II binding; insulin-like growth factor receptor activity; G-protein coupled receptor activity; protein binding; enzyme binding; glycoprotein binding

Biological Process: receptor-mediated endocytosis; G-protein coupled receptor protein signaling pathway; organ regeneration; response to retinoic acid; insulin-like growth factor receptor signaling pathway; positive regulation of apoptosis; spermatogenesis; signal transduction; liver development; post-embryonic development

Disease: Hepatocellular Carcinoma