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KCNA10 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS416925

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability,… More details

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Technical Datasheet View PDF
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Product Overview

Product Name
KCNA10, Polyclonal Antibody
Full Product Name
Anti-KCNA10 Antibody
Product Gene Name
anti-KCNA10 antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human. Predicted: Mouse, Rat. Not yet tested in other species.
Form/Format
Liquid
Purity/Purification
Affinity purified
Concentration
100ug/100ul (lot specific)
Preparation and Storage
This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Molecular Weight
57,785 Da
OMIM
602420
Storage Buffer
PBS, pH 7.4 with 0.02% sodium azide.
Immunogen
Rabbit polyclonal KCNA10 (1) antibody was raised against a peptide from the intermediate residues of human KCNA10 protein (NP_005540.1).
Applications Tested/Suitable for anti-KCNA10 antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-KCNA10 antibody
ELISA titer: 1:20,000-1:80,000
Western blot analysis: 1:500-1:1,000
Optimal dilutions/concentrations should be determined by the end user

Product References and Citations for anti-KCNA10 antibody

(1) Bailey,S.D., Xie,C., Do,R., et al. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes Reduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. Diabetes Care 33 (10), 2250-2253 (2010)

Other Notes

Small volumes of anti-KCNA10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for KCNA10 purchase

MBS416925 is an antibody targeting KCNA10. Reactive in Human. Predicted: Mouse, Rat. Not yet tested in other species.. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for KCNA10. It may not necessarily be applicable to this product.

NCBI GI #
5031819
NCBI GeneID
3744
NCBI Accession #
NP_005540.1
UniProt Related Accession #
Q16322
GenBank Nucleotide #
NM_005549.2
NCBI Official Full Name
potassium voltage-gated channel subfamily A member 10
NCBI Official Synonym Full Names
potassium channel, voltage gated shaker related subfamily A, member 10
NCBI Official Symbol
KCNA10
NCBI Official Synonym Symbols
Kcn1; Kv1.8
UniProt Protein Name
Potassium voltage-gated channel subfamily A member 10
UniProt Synonym Protein Names
Voltage-gated potassium channel subunit Kv1.8
Protein Family
Potassium voltage-gated channel subfamily
UniProt Gene Name
KCNA10
UniProt Entry Name
KCA10_HUMAN
NCBI Protein Information
potassium voltage-gated channel subfamily A member 10; cyclic GMP gated potassium channel; potassium voltage-gated channel, shaker-related subfamily, member 10; voltage-gated potassium channel subunit Kv1.8

UniProt Comments for KCNA10

KCNA10: Mediates voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. The channel activity is up-regulated by cAMP. Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.8/KCNA10 sub-subfamily. Homotetramer. Interacts with KCN4B/POMP. Interaction with KCN4B/POMP is necessary for the modulation of channel activity by cAMP

Protein type: Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 1p13.1

Cellular Component: voltage-gated potassium channel complex; plasma membrane; integral to membrane

Molecular Function: delayed rectifier potassium channel activity; intracellular cyclic nucleotide activated cation channel activity

Biological Process: synaptic transmission; protein homooligomerization; potassium ion transport
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Research Articles on KCNA10

1. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-KCNA10 antibody

 Reference Product  PubMed Publications
 KCNG2 antibody  >1 publications with KCNA10 and KCNG2
 KCNV2 antibody  >1 publications with KCNA10 and KCNV2
 KCNQ1 antibody  >1 publications with KCNA10 and KCNQ1

Pathways associated with anti-KCNA10 antibody

 Products by Pathway  Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
 Potassium Channels Pathway antibodies  Potassium Channels Pathway Diagram
 Voltage Gated Potassium Channels Pathway antibodies  Voltage Gated Potassium Channels Pathway Diagram

Diseases associated with anti-KCNA10 antibody

 Disease Name  Pubmed Publications
 Heart Diseases Antibodies  >1 publications with KCNA10 and Heart Diseases
 Hypertension Antibodies  >1 publications with KCNA10 and Hypertension
 Cardiovascular Abnormalities Antibodies  >1 publications with KCNA10 and Cardiovascular Abnormalities
 Arrhythmias, Cardiac Antibodies  >1 publications with KCNA10 and Arrhythmias, Cardiac
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