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ARNTL2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS417053

This gene encodes a basic helix-loop-helix transcription factor belonging to the PAS (PER, ARNT, SIM) superfamily. The PAS proteins play important roles in adaptation to low atmospheric and cellular oxygen levels, exposure to certain environmental pollutants,… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
ARNTL2, Polyclonal Antibody
Full Product Name
Anti-ARNTL2 Antibody
Product Gene Name
anti-ARNTL2 antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human. Predicted: Mouse, Rat
Form/Format
Liquid
Purity/Purification
Affinity purified
Concentration
100ug/100ul (lot specific)
Preparation and Storage
This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Molecular Weight
60,390 Da
OMIM
614517
Storage Buffer
PBS, pH 7.4 with 0.02% sodium azide.
Immunogen
Rabbit polyclonal ARNTL2(1) antibody was raised against a recombinate human ARNTL2 protein 14-206aa (BC125062).
Applications Tested/Suitable for anti-ARNTL2 antibody
ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-ARNTL2 antibody
ELISA titer: 1:20,000-1:80,000
Immunohistochemistry: 1:100-1:500
Optimal dilutions/concentrations should be determined by the end user

Testing Data of anti-ARNTL2 antibody

Rabbit Anti-ARNTL2 Polyclonal Antibody – Cat# MBS417053

Product References and Citations for anti-ARNTL2 antibody

(1) Mazzoccoli,G., Pazienza,V., Panza,A., et al. ARNTL2 and SERPINE1: potential biomarkers for tumor aggressiveness in colorectal cancer. J. Cancer Res. Clin. Oncol. 138 (3), 501-511 (2012)

Other Notes

Small volumes of anti-ARNTL2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ARNTL2 purchase

MBS417053 is an antibody targeting ARNTL2. Reactive in Human. Predicted: Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ARNTL2. It may not necessarily be applicable to this product.

NCBI GI #
115529028
NCBI GeneID
56938
NCBI Accession #
BC125062
UniProt Secondary Accession #
Q8WYA2; Q8WYA3; Q8WYA4; Q96J63; Q9H2M4; Q9NS70; Q9NYQ4; Q9NYQ5; B7Z429; F5H402
UniProt Related Accession #
Q8WYA1
NCBI Official Full Name
Homo sapiens aryl hydrocarbon receptor nuclear translocator-like 2, mRNA
NCBI Official Synonym Full Names
aryl hydrocarbon receptor nuclear translocator-like 2
NCBI Official Symbol
ARNTL2
NCBI Official Synonym Symbols
CLIF; MOP9; BMAL2; PASD9; bHLHe6
UniProt Protein Name
Aryl hydrocarbon receptor nuclear translocator-like protein 2
UniProt Synonym Protein Names
Basic-helix-loop-helix-PAS protein MOP9; Brain and muscle ARNT-like 2; CYCLE-like factor; CLIF; Class E basic helix-loop-helix protein 6; bHLHe6; Member of PAS protein 9; PAS domain-containing protein 9
Protein Family
Aryl hydrocarbon receptor nuclear translocator-like protein
UniProt Gene Name
ARNTL2
UniProt Entry Name
BMAL2_HUMAN
NCBI Protein Information
aryl hydrocarbon receptor nuclear translocator-like protein 2; CYCLE-like factor; PAS domain-containing protein 9; basic-helix-loop-helix-PAS protein MOP9; brain and muscle ARNT-like 2; class E basic helix-loop-helix protein 6; member of PAS protein 9; transcription factor BMAL2

UniProt Comments for ARNTL2

ARNTL2: ARNTL2-CLOCK heterodimers activate E-box element (5'- CACGTG-5') transcription. Also, in umbilical vein endothelial cells, activates SERPINE1 through E-box sites. This transactivation is inhibited by PER2 and CRY1. 8 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 12p12.2-p11.2

Cellular Component: transcription factor complex; cytoplasm; nucleolus; nucleus

Molecular Function: protein dimerization activity; signal transducer activity; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; circadian rhythm; regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; positive regulation of circadian rhythm; entrainment of circadian clock; signal transduction
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Research Articles on ARNTL2

1. there is significant association between diurnal preference and a polymorphism in PER3 and a novel nominally significant association between diurnal preference and a polymorphism in ARNTL2

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-ARNTL2 antibody

 Products by Pathway  Pathway Diagram
 BMAL1:CLOCK,NPAS2 Activates Circadian Gene Expression Pathway antibodies  BMAL1:CLOCK,NPAS2 Activates Circadian Gene Expression Pathway Diagram
 Circadian Clock Pathway antibodies  Circadian Clock Pathway Diagram

Diseases associated with anti-ARNTL2 antibody

 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >7 publications with ARNTL2 and Immune System Diseases
 Heart Diseases Antibodies  >3 publications with ARNTL2 and Heart Diseases
 Liver Diseases Antibodies  >2 publications with ARNTL2 and Liver Diseases
 Cell Transformation, Neoplastic Antibodies  >2 publications with ARNTL2 and Cell Transformation, Neoplastic
 Weight Gain Antibodies  >1 publications with ARNTL2 and Weight Gain
 Atrophy Antibodies  >1 publications with ARNTL2 and Atrophy
 Carcinoma, Hepatocellular Antibodies  >1 publications with ARNTL2 and Carcinoma, Hepatocellular
 Weight Loss Antibodies  >1 publications with ARNTL2 and Weight Loss
 Kidney Diseases Antibodies  >1 publications with ARNTL2 and Kidney Diseases
 Liver Neoplasms Antibodies  >1 publications with ARNTL2 and Liver Neoplasms

Organs/Tissues associated with anti-ARNTL2 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >10 publications with ARNTL2 and Blood
 Brain Antibodies  >9 publications with ARNTL2 and Brain
 Liver Antibodies  >4 publications with ARNTL2 and Liver
 Muscle Antibodies  >4 publications with ARNTL2 and Muscle
 Heart Antibodies  >2 publications with ARNTL2 and Heart
 Lung Antibodies  >2 publications with ARNTL2 and Lung
 Eye Antibodies  >2 publications with ARNTL2 and Eye
 Prostate Antibodies  >1 publications with ARNTL2 and Prostate
 Trachea Antibodies  >1 publications with ARNTL2 and Trachea
 Embryonic Tissue Antibodies  >1 publications with ARNTL2 and Embryonic Tissue
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