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EFHC1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS9128391
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This gene encodes an EF-hand-containing calcium binding protein. The encoded protein likely plays a role in calcium homeostasis. Mutations in this gene have been associated with susceptibility to juvenile myoclonic epilepsy and juvenile absence epilepsy.… More details

$225 / 0.02 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
EFHC1, Polyclonal Antibody
Full Product Name
EFHC1 Polyclonal Antibody
Product Gene Name
anti-EFHC1 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Affinity Purification
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Molecular Weight
74kDa
OMIM
254770
3D Structure
ModBase 3D Structure for Q5JVL4
Immunogen
Recombinant protein of human EFHC1
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-EFHC1 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-EFHC1 antibody
WB 1:500 - 1:2000
IHC 1:50 - 1:200

Western Blot (WB) of anti-EFHC1 antibody

Western blot analysis of extracts of various cell lines, using EFHC1 antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 90s.
Rabbit Anti-EFHC1 Polyclonal Antibody – Cat# MBS9128391

Immunohistochemistry (IHC) of anti-EFHC1 antibody

Immunohistochemistry of paraffin-embedded human stomach using EFHC1 antibody at dilution of 1:100 (40x lens).
Rabbit Anti-EFHC1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS9128391

Immunohistochemistry (IHC) of anti-EFHC1 antibody

Immunohistochemistry of paraffin-embedded rat brain using EFHC1 antibody at dilution of 1:100 (40x lens).
Rabbit Anti-EFHC1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS9128391

Immunohistochemistry (IHC) of anti-EFHC1 antibody

Immunohistochemistry of paraffin-embedded mouse stomach using EFHC1 antibody at dilution of 1:100 (40x lens).
Rabbit Anti-EFHC1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS9128391

Other Notes

Small volumes of anti-EFHC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for EFHC1 purchase

MBS9128391 is an antibody targeting EFHC1. Also known as EFHC1 Polyclonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for EFHC1. It may not necessarily be applicable to this product.

NCBI GI #
289063386
NCBI GeneID
114327
NCBI Accession #
NP_001165891.1
UniProt Primary Accession #
Q5JVL4
UniProt Secondary Accession #
Q5XKM4; Q6E1U7; Q6E1U8; Q8WUL2; Q9NVW6; B4DMU3; F5GZD8
UniProt Related Accession #
Q5JVL4
GenBank Nucleotide #
NM_001172420.1
NCBI Official Full Name
EF-hand domain-containing protein 1 isoform 2
NCBI Official Synonym Full Names
EF-hand domain (C-terminal) containing 1
NCBI Official Symbol
EFHC1
NCBI Official Synonym Symbols
EJM1; dJ304B14.2
UniProt Protein Name
EF-hand domain-containing protein 1
UniProt Synonym Protein Names
Myoclonin-1
Protein Family
EF-hand domain-containing protein
UniProt Gene Name
EFHC1
UniProt Entry Name
EFHC1_HUMAN
NCBI Protein Information
EF-hand domain-containing protein 1

UniProt Comments for EFHC1

EFHC1: microtubule-associated protein (MAP) that is abundant in sperm flagella and motile cilia but expressed at low levels in the adult brain. It is not present in immotile primary cilia. May enhance calcium influx through CACNA1E and stimulate programmed cell death. Interacts with the C-terminus of CACNA1E. Implicated in neuronal migration and may play a role during brain development. Mutations in EFHC1 gene have been previously reported in patients with epilepsies, including those with juvenile myoclonic epilepsy. Two alternatively spliced human isoforms have been described.

Chromosomal Location of Human Ortholog: 6p12.3

Cellular Component: centrosome; cell soma; axoneme

Molecular Function: protein C-terminus binding; calcium ion binding

Biological Process: cerebral cortex cell migration

Disease: Epilepsy, Myoclonic Juvenile; Epilepsy, Juvenile Absence, Susceptibility To, 1
Show more

Research Articles on EFHC1

1. some EFHC1 mutations may be pathogenic only when introduced into specific genetic backgrounds to juvenile myoclonic epilepsy

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-EFHC1 antibody

 Reference Product  PubMed Publications
 GABRA1 antibody  >9 publications with EFHC1 and GABRA1
 BRD2 antibody  >8 publications with EFHC1 and BRD2
 CLCN2 antibody  >5 publications with EFHC1 and CLCN2
 CACNB4 antibody  >2 publications with EFHC1 and CACNB4
 GABRD antibody  >1 publications with EFHC1 and GABRD
 CACNA1E antibody  >1 publications with EFHC1 and CACNA1E

Diseases associated with anti-EFHC1 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >41 publications with EFHC1 and Nervous System Diseases
 Myoclonic Epilepsy, Juvenile Antibodies  >41 publications with EFHC1 and Myoclonic Epilepsy, Juvenile
 Brain Diseases Antibodies  >40 publications with EFHC1 and Brain Diseases
 Epilepsy, Absence Antibodies  >9 publications with EFHC1 and Epilepsy, Absence
 Neurodegenerative Diseases Antibodies  >1 publications with EFHC1 and Neurodegenerative Diseases
 Acute Kidney Injury Antibodies  >1 publications with EFHC1 and Acute Kidney Injury

Organs/Tissues associated with anti-EFHC1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >21 publications with EFHC1 and Brain
 Muscle Antibodies  >2 publications with EFHC1 and Muscle
 Embryonic Tissue Antibodies  >1 publications with EFHC1 and Embryonic Tissue
 Kidney Antibodies  >1 publications with EFHC1 and Kidney
 Uncharacterized Tissue Antibodies  >1 publications with EFHC1 and Uncharacterized Tissue
 Lung Antibodies  >1 publications with EFHC1 and Lung
 Testis Antibodies  >1 publications with EFHC1 and Testis
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