Rabbit Anti-APBB2 Polyclonal Antibody – Cat# MBS417769

APBB2 Antibody – Rabbit Polyclonal

Name: APBB2 Antibody; Polyclonal; Rabbit; Human/Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS417769
Price: 335 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS417769

This gene interacts with the cytoplasmic domains of amyloid beta (A4) precursor protein and amyloid beta (A4) precursor-like protein 2. This protein contains two phosphotyrosine binding (PTB) domains, which are thought to function in signal transduction.… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

APBB2, Polyclonal Antibody

Full Product Name

Anti-APBB2 Antibody

Product Gene Name

anti-APBB2 antibody

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Human. Predicted: Mouse, Rat

Form/Format

Liquid

Purity/Purification

Affinity purified

Concentration

100ug/100ul (lot specific)

Preparation and Storage

This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

Molecular Weight

83,445 Da

OMIM

602710

Storage Buffer

PBS, pH 7.4 with 0.02% sodium azide.

Immunogen

Rabbit polyclonal APBB2(1) antibody was raised against a recombinate human APBB2 protein 519-731aa (BC027946).

Applications Tested/Suitable for anti-APBB2 antibody

ELISA (EIA), Western Blot (WB)

Application Notes for anti-APBB2 antibody

ELISA titer: 1:20,000-1:80,000
Western blot analysis: 1:500-1:1,000
Optimal dilutions/concentrations should be determined by the end user

Product References and Citations for anti-APBB2 antibody

(1) Shimada,M., Miyagawa,T., Kawashima,M.,et al. An approach based on a genome-wide association study reveals candidate loci for narcolepsy.Hum. Genet. 128 (4), 433-441 (2010)

Other Notes

Small volumes of anti-APBB2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for APBB2 purchase

MBS417769 is an antibody targeting APBB2. Reactive in Human. Predicted: Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for APBB2. It may not necessarily be applicable to this product.

NCBI GI #

24081023

NCBI GeneID

323

NCBI Accession #

BC027946

UniProt Secondary Accession #

Q8IUI6; B4DSL4; E9PG87

UniProt Related Accession #

Q92870

NCBI Official Full Name

Homo sapiens amyloid beta (A4) protein-binding, family B, member 2, mRNA

NCBI Official Synonym Full Names

amyloid beta (A4) precursor protein-binding, family B, member 2

NCBI Official Symbol

APBB2

NCBI Official Synonym Symbols

FE65L; FE65L1

UniProt Protein Name

Amyloid beta A4 precursor protein-binding family B member 2

UniProt Synonym Protein Names

Protein Fe65-like 1

Protein Family

Amyloid beta A4 precursor protein-binding family

UniProt Gene Name

APBB2

UniProt Entry Name

APBB2_HUMAN

NCBI Protein Information

amyloid beta A4 precursor protein-binding family B member 2; Fe65-like 1; protein Fe65-like 1

NCBI Summary for APBB2

The protein encoded by this gene interacts with the cytoplasmic domains of amyloid beta (A4) precursor protein and amyloid beta (A4) precursor-like protein 2. This protein contains two phosphotyrosine binding (PTB) domains, which are thought to function in signal transduction. Polymorphisms in this gene have been associated with Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

UniProt Comments for APBB2

APBB2: May modulate the internalization of beta-amyloid precursor protein. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis

Chromosomal Location of Human Ortholog: 4p13

Cellular Component: growth cone; membrane; lamellipodium; cytoplasm; synapse; nucleus

Molecular Function: protein binding; beta-amyloid binding; transcription factor binding

Biological Process: axon guidance; extracellular matrix organization and biogenesis; regulation of transcription, DNA-dependent; positive regulation of apoptosis; neuron migration; negative regulation of cell growth; cell cycle arrest; negative regulation of apoptosis

Disease: Alzheimer Disease

Research Articles on APBB2

1. The APBB2 rs13133980 G allele was over-represented in centenarians with severe cognitive impairment compared to individuals without this disability.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-APBB2 antibody

Reference Product	PubMed Publications
APP antibody	>10 publications with APBB2 and APP
APLP1 antibody	>2 publications with APBB2 and APLP1
APLP2 antibody	>2 publications with APBB2 and APLP2
CYP46A1 antibody	>1 publications with APBB2 and CYP46A1
APBA1 antibody	>1 publications with APBB2 and APBA1
APBA2 antibody	>1 publications with APBB2 and APBA2

Diseases associated with anti-APBB2 antibody

Disease Name	Pubmed Publications
Alzheimer Disease Antibodies	>9 publications with APBB2 and Alzheimer Disease
Brain Diseases Antibodies	>8 publications with APBB2 and Brain Diseases
Necrosis Antibodies	>5 publications with APBB2 and Necrosis
Atherosclerosis Antibodies	>1 publications with APBB2 and Atherosclerosis

Organs/Tissues associated with anti-APBB2 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>6 publications with APBB2 and Brain
Nerve Antibodies	>4 publications with APBB2 and Nerve
Bladder Antibodies	>1 publications with APBB2 and Bladder
Liver Antibodies	>1 publications with APBB2 and Liver
Prostate Antibodies	>1 publications with APBB2 and Prostate
Spleen Antibodies	>1 publications with APBB2 and Spleen
Vascular Antibodies	>1 publications with APBB2 and Vascular
Kidney Antibodies	>1 publications with APBB2 and Kidney