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HEPH Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS418133

HEPH (Hephaestin) may function as a ferroxidase for ferrous (II) to ferric ion (III) conversion and may be involved in copper transport and homeostasis. The protein is implicated in iron homeostasis and may mediate iron efflux associated to ferroportin 1.… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
HEPH (Hephaestin), Polyclonal Antibody
Full Product Name
Anti-HEPH (Hephaestin)- (C-terminal) Antibody
Product Gene Name
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Rat
Form/Format
Liquid
Purity/Purification
Purified by antigen-specific affinity chromatography.
Concentration
1ug/ul (lot specific)
Preparation and Storage
This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Molecular Weight
100,624 Da
OMIM
AJ296162 mRNA
Immunogen
Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human HEPH (Hephaestin precursor)
Storage Buffer
PBS, pH 7.4 with 0.05% sodium azide.
Applications Tested/Suitable for anti-HEPH antibody
Western Blot (WB), ELISA (EIA)

Product References and Citations for anti-HEPH antibody

Syed, B.A., et al, Protein Eng. 15 (3), 205-214 (2002) Ishikawa, K., et al, DNA Res. 5 (3), 169-176 (1998)

Other Notes

Small volumes of anti-HEPH antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HEPH purchase

MBS418133 is an antibody targeting HEPH. Also known as Anti-HEPH (Hephaestin)- (C-terminal) Antibody. Reactive in Human, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for HEPH. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
hephaestin
NCBI Official Synonym Full Names
hephaestin
NCBI Official Symbol
HEPH
NCBI Official Synonym Symbols
CPL
UniProt Protein Name
Hephaestin
Protein Family
UniProt Gene Name
HEPH
UniProt Synonym Gene Names
KIAA0698
NCBI Protein Information
hephaestin

NCBI Summary for HEPH

This gene encodes a member of the multicopper oxidase protein family. The encoded protein is involved in the transport of dietary iron from epithelial cells of the intestinal lumen into the circulatory system, and may be involved in copper transport and homeostasis. In mouse, defects in this gene can lead to severe microcytic anemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
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UniProt Comments for HEPH

HEPH: May function as a ferroxidase for ferrous (II) to ferric ion (III) conversion and may be involved in copper transport and homeostasis. Implicated in iron homeostasis and may mediate iron efflux associated to ferroportin 1. Belongs to the multicopper oxidase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 1.-.-.-; Membrane protein, integral; Oxidoreductase

Chromosomal Location of Human Ortholog: Xq12

Cellular Component: basolateral plasma membrane; intracellular; plasma membrane

Molecular Function: copper ion binding; ferrous iron binding; ferroxidase activity

Biological Process: cellular iron ion homeostasis; iron ion transport
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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