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AKR1C1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8231252

MBS8231252 is an antibody targeting AKR1C1. Reactive in Human, Mouse, Rat. Host: Rabbit. Rabbit polyclonal antibody to AKR1C1 More details

$225 / 0.03 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
AKR1C1, Polyclonal Antibody
Full Product Name
Anti-AKR1C1 Antibody
Product Gene Name
anti-AKR1C1 antibody
Product Synonym Names
DDH; DDH1; Aldo-keto reductase family 1 member C1; 20-alpha-hydroxysteroid dehydrogenase; 20-alpha-HSD; Chlordecone reductase homolog HAKRC; Dihydrodiol dehydrogenase 1/2; DD1/DD2; High-affinity hepatic bile acid-binding protein; HBAB; Indanol dehydrogenase; Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Specificity
Recognizes endogenous levels of AKR1C1 protein.
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Antibody/Peptide Pairs
AKR1C1 peptide (MBS8210920) is used for blocking the activity of AKR1C1 antibody (MBS8231252)
Molecular Weight
36,788 Da
OMIM
600449
3D Structure
ModBase 3D Structure for Q04828
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human AKR1C1. The exact sequence is proprietary.
Applications Tested/Suitable for anti-AKR1C1 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-AKR1C1 antibody
WB (1/500 - 1/1000), IHC (1/100 - 1/200)

Western Blot (WB) of anti-AKR1C1 antibody

Western blot analysis of AKR1C1 expression in HeLa (A), HepG2 (B) whole cell lysates.
Rabbit Anti-AKR1C1 Polyclonal Antibody – Cat# MBS8231252

Immunohistochemistry (IHC) of anti-AKR1C1 antibody

Immunohistochemical analysis of AKR1C1 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
Rabbit Anti-AKR1C1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS8231252

Other Notes

Small volumes of anti-AKR1C1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for AKR1C1. It may not necessarily be applicable to this product.

NCBI GI #
5453543
NCBI GeneID
1645
NCBI Accession #
NP_001344.2
UniProt Primary Accession #
Q04828
UniProt Secondary Accession #
P52896; Q5SR15; Q7M4N2; Q9UCX2
UniProt Related Accession #
Q04828
GenBank Nucleotide #
NM_001353.5
NCBI Official Full Name
aldo-keto reductase family 1 member C1
NCBI Official Synonym Full Names
aldo-keto reductase family 1, member C1
NCBI Official Symbol
AKR1C1
NCBI Official Synonym Symbols
C9; DD1; DDH; DDH1; H-37; HBAB; MBAB; HAKRC; DD1/DD2; 2-ALPHA-HSD; 20-ALPHA-HSD
UniProt Protein Name
Aldo-keto reductase family 1 member C1
UniProt Synonym Protein Names
20-alpha-hydroxysteroid dehydrogenase (EC:1.1.1.149); 20-alpha-HSD; Chlordecone reductase homolog HAKRC; Dihydrodiol dehydrogenase 1/2; DD1/DD2; High-affinity hepatic bile acid-binding protein; HBAB; Indanol dehydrogenase (EC:1.1.1.112); Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase (EC:1.3.1.20)
Protein Family
Aldo-keto reductase family
UniProt Gene Name
AKR1C1
UniProt Synonym Gene Names
DDH; DDH1; 20-alpha-HSD; DD1/DD2; HBAB
UniProt Entry Name
AK1C1_HUMAN
NCBI Protein Information
aldo-keto reductase family 1 member C1

NCBI Summary for AKR1C1

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reaction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. [provided by RefSeq, Jul 2008]
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UniProt Comments for AKR1C1

AKR1C1: Converts progesterone to its inactive form, 20-alpha- dihydroxyprogesterone (20-alpha-OHP). In the liver and intestine, may have a role in the transport of bile. May have a role in monitoring the intrahepatic bile acid concentration. Has a low bile-binding ability. May play a role in myelin formation. Belongs to the aldo/keto reductase family.

Protein type: EC 1.1.1.112; EC 1.1.1.149; Oxidoreductase; EC 1.3.1.20; Xenobiotic Metabolism - metabolism by cytochrome P450

Chromosomal Location of Human Ortholog: 10p15-p14

Cellular Component: cytosol

Molecular Function: oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor; ketosteroid monooxygenase activity; 3-alpha-hydroxysteroid dehydrogenase (B-specific) activity; carboxylic acid binding; bile acid binding; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity; aldo-keto reductase activity; 20-alpha-hydroxysteroid dehydrogenase activity; indanol dehydrogenase activity; aldehyde reductase activity; phenanthrene 9,10-monooxygenase activity

Biological Process: bile acid and bile salt transport; phototransduction, visible light; cholesterol homeostasis; response to organophosphorus; retinal metabolic process; epithelial cell differentiation; bile acid metabolic process; xenobiotic metabolic process; cholesterol absorption; digestion; progesterone metabolic process; retinoid metabolic process; protein homooligomerization
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Research Articles on AKR1C1

1. results suggest a gender-specific modulatory effect of AKR1C1 on anxiety levels, most likely through changes in progesterone and allopregnanolone levels within and outside the brain

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-AKR1C1 antibody

 Reference Product  PubMed Publications
 SRD5A1 antibody  >13 publications with AKR1C1 and SRD5A1
 GCLC antibody  >5 publications with AKR1C1 and GCLC
 ALDH3A1 antibody  >4 publications with AKR1C1 and ALDH3A1
 ADH7 antibody  >1 publications with AKR1C1 and ADH7
 HSD17B6 antibody  >1 publications with AKR1C1 and HSD17B6

Pathways associated with anti-AKR1C1 antibody

 Products by Pathway  Pathway Diagram
 Benzo(a)pyrene Metabolism Pathway antibodies  Benzo(a)pyrene Metabolism Pathway Diagram
 Bile Acid And Bile Salt Metabolism Pathway antibodies  Bile Acid And Bile Salt Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Metabolism Of Xenobiotics By Cytochrome P450 Pathway antibodies  Metabolism Of Xenobiotics By Cytochrome P450 Pathway Diagram
 Metabolism Of Xenobiotics By Cytochrome P450 Pathway antibodies  Metabolism Of Xenobiotics By Cytochrome P450 Pathway Diagram
 Retinoid Metabolism And Transport Pathway antibodies  Retinoid Metabolism And Transport Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Steroid Hormone Biosynthesis Pathway antibodies  Steroid Hormone Biosynthesis Pathway Diagram
 Steroid Hormone Biosynthesis Pathway antibodies  Steroid Hormone Biosynthesis Pathway Diagram

Diseases associated with anti-AKR1C1 antibody

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >19 publications with AKR1C1 and Breast Neoplasms
 Adenocarcinoma Antibodies  >13 publications with AKR1C1 and Adenocarcinoma
 Endometriosis Antibodies  >11 publications with AKR1C1 and Endometriosis
 Lung Neoplasms Antibodies  >11 publications with AKR1C1 and Lung Neoplasms
 Gastrointestinal Diseases Antibodies  >8 publications with AKR1C1 and Gastrointestinal Diseases
 Liver Neoplasms Antibodies  >6 publications with AKR1C1 and Liver Neoplasms
 Neoplasms, Hormone-Dependent Antibodies  >5 publications with AKR1C1 and Neoplasms, Hormone-Dependent
 Immune System Diseases Antibodies  >5 publications with AKR1C1 and Immune System Diseases
 Carcinoma, Hepatocellular Antibodies  >5 publications with AKR1C1 and Carcinoma, Hepatocellular
 Carcinoma, Non-Small-Cell Lung Antibodies  >5 publications with AKR1C1 and Carcinoma, Non-Small-Cell Lung

Organs/Tissues associated with anti-AKR1C1 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >29 publications with AKR1C1 and Liver
 Lung Antibodies  >26 publications with AKR1C1 and Lung
 Ovary Antibodies  >11 publications with AKR1C1 and Ovary
 Uterus Antibodies  >11 publications with AKR1C1 and Uterus
 Adipose Tissue Antibodies  >9 publications with AKR1C1 and Adipose Tissue
 Connective Tissue Antibodies  >9 publications with AKR1C1 and Connective Tissue
 Blood Antibodies  >8 publications with AKR1C1 and Blood
 Skin Antibodies  >8 publications with AKR1C1 and Skin
 Brain Antibodies  >7 publications with AKR1C1 and Brain
 Kidney Antibodies  >7 publications with AKR1C1 and Kidney
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