Lysosomal Acid Lipase (LAL) Antibody – Mouse Monoclonal

Lysosomal acid lipase (LAL), with 378-amino acid protein (43-54 kDa), functions in the lysosome to catalyze the hydrolysis of cholesteryl esters and triglycerides which are taken up by receptor-mediated endocytosis. An inherited deficiency or low activity of human lysosomal acid lipase results in the intralysosomal storage of the respective lipid substrates. So it is also responsible for the rare conditions of Wolman disease and cholesteryl ester storage disease (CESD). As the enzyme is synthesized by all nucleated cells, lipid-laden cells are found in all organs, particularly in liver, spleen, the adrenal and the hemopoietic system, and in the intestine as well as in the lymph nodes, lungs, testes, and ovaries.

1. Uta Drebber, Matthias Andersen, Hans U Kasper, et al, World J Gastroenterol. 2005 Apr 21;11 (15):2364-6 2. Renata Boldrini, Rita Devito, R.Biselli, et al, Pathol Res Pract. 2004;200 (3):231-40

Small volumes of anti-LAL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS418401 is an antibody targeting LAL. Also known as Anti-Lysosomal acid lipase (LAL) Antibody. Reactive in Human. Host: Mouse.