Dopamine Receptor D1 / DRD1 (DRD1) Antibody – Goat Polyclonal

This gene encodes the D1 subtype of the dopamine receptor. The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. D1 receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2-mediated events. Alternate transcription initiation sites result in two transcript variants of this gene. [provided by RefSeq, Jul 2008]

DRD1: a G-protein coupled receptor.One of the five types (D1 to D5) of receptors for dopamine. The most abundant dopamine receptor in the central nervous system. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Interacts with calcyon.

Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 5q35.2

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: dopamine binding; dopamine D1 receptor-like receptor activity; dopamine receptor activity; protein binding

Biological Process: adenylate cyclase activation; adult walking behavior; cerebral cortex GABAergic interneuron migration; dopamine metabolic process; dopamine receptor, adenylate cyclase activating pathway; dopamine receptor, phospholipase C activating pathway; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); G-protein signaling, adenylate cyclase activating pathway; G-protein signaling, coupled to cyclic nucleotide second messenger; learning; mating behavior; positive regulation of cAMP biosynthetic process; positive regulation of cell migration; positive regulation of potassium ion transport; positive regulation of release of sequestered calcium ion into cytosol; positive regulation of synaptic transmission, glutamatergic; prepulse inhibition; regulation of dopamine uptake; response to drug; synaptic transmission, dopaminergic; synaptogenesis; transmission of nerve impulse; visual learning