LIPC Antibody – Rabbit Polyclonal

LIPC: Hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-CoA thioesters. It is an important enzyme in HDL metabolism. Hepatic lipase binds heparin. Defects in LIPC are the cause of hepatic lipase deficiency (HL deficiency). A disorder characterized by elevated levels of beta-migrating very low density lipoproteins, and abnormally triglyceride-rich low and high density lipoproteins. Belongs to the AB hydrolase superfamily. Lipase family.

Protein type: EC 3.1.1.3; Lipid Metabolism - glycerolipid; Phospholipase; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 15q21.3

Cellular Component: endoplasmic reticulum lumen; extracellular region; extracellular space

Molecular Function: apolipoprotein binding; low-density lipoprotein binding; phospholipase activity; triacylglycerol lipase activity

Biological Process: cholesterol homeostasis; fatty acid biosynthetic process; lipid digestion; reverse cholesterol transport; triacylglycerol catabolic process

Disease: Diabetes Mellitus, Noninsulin-dependent; Hepatic Lipase Deficiency; High Density Lipoprotein Cholesterol Level Quantitative Trait Locus 12