MS2/ADAM8/CD156 (ADAM8) Antibody – Goat Polyclonal

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene may be involved in cell adhesion during neurodegeneration, and it is thought to be a target for allergic respiratory diseases, including asthma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2009]

ADAM8: Possible involvement in extravasation of leukocytes.

Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; EC 3.4.24.-; Protease

Chromosomal Location of Human Ortholog: 10q26.3

Cellular Component: cell surface; cytoplasm; dense core granule membrane; integral to plasma membrane; plasma membrane; podosome; specific granule

Molecular Function: calcium ion binding; cell adhesion molecule binding; metalloendopeptidase activity; metallopeptidase activity; protein binding; protein self-association; serine-type endopeptidase activity; zinc ion binding

Biological Process: activation of NF-kappaB transcription factor; angiogenesis; cell morphogenesis; cell-cell adhesion; extracellular matrix disassembly; inflammatory response; leukocyte migration during inflammatory response; lymphocyte chemotaxis; negative regulation of neuron apoptosis; positive regulation of acute inflammatory response; positive regulation of bone resorption; positive regulation of cell adhesion; positive regulation of membrane protein ectodomain proteolysis; positive regulation of protein kinase B signaling cascade; positive regulation of protein secretion; positive regulation of T cell differentiation in the thymus; proteolysis; regulation of cell-cell adhesion