NP_001636.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
9,332 Da
NCBI Official Full Name
apolipoprotein C-I
NCBI Official Synonym Full Names
apolipoprotein C1
NCBI Official Synonym Symbols
Apo-CI; ApoC-I; apo-CIB; apoC-IB [Similar Products]
NCBI Protein Information
apolipoprotein C-I
UniProt Protein Name
Apolipoprotein C-I
UniProt Synonym Protein Names
Apolipoprotein C1
UniProt Synonym Gene Names
UniProt Entry Name
APOC1_HUMAN
NCBI Summary for APOC1
This gene encodes a member of the apolipoprotein C1 family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. The encoded protein plays a central role in high density lipoprotein (HDL) and very low density lipoprotein (VLDL) metabolism. This protein has also been shown to inhibit cholesteryl ester transfer protein in plasma. A pseudogene of this gene is located 4 kb downstream in the same orientation, on the same chromosome. This gene is mapped to chromosome 19, where it resides within a apolipoprotein gene cluster. [provided by RefSeq, Mar 2016]
UniProt Comments for APOC1
APOC1: Appears to modulate the interaction of APOE with beta- migrating VLDL and inhibit binding of beta-VLDL to the LDL receptor-related protein. Binds free fatty acids and reduces their intracellular esterification. Belongs to the apolipoprotein C1 family.
Protein type: Lipid-binding; Inhibitor; Endoplasmic reticulum; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 19q13.2
Cellular Component: chylomicron; endoplasmic reticulum
Molecular Function: fatty acid binding; lipase inhibitor activity; phosphatidylcholine binding; phospholipase inhibitor activity
Biological Process: cholesterol efflux; cholesterol metabolic process; lipid metabolic process; lipoprotein metabolic process; negative regulation of cholesterol transport; negative regulation of fatty acid biosynthetic process; negative regulation of lipid catabolic process; negative regulation of lipid metabolic process; negative regulation of lipoprotein lipase activity; negative regulation of receptor-mediated endocytosis; phospholipid efflux; positive regulation of catalytic activity; regulation of cholesterol transport; triacylglycerol metabolic process
Research Articles on APOC1
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Products associated with anti-APOC1 antibody
Pathways associated with anti-APOC1 antibody
Diseases associated with anti-APOC1 antibody
Organs/Tissues associated with anti-APOC1 antibody
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