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AKAP8 Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS420061

MBS420061 is an antibody targeting AKAP8. Also known as Goat anti-AKAP8/AKAP95 Antibody. Reactive in Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Cow. Host: Goat. More details

$450 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
AKAP8/AKAP95, Polyclonal Antibody
Full Product Name
Goat anti-AKAP8/AKAP95 Antibody
Product Gene Name
anti-AKAP8 antibody
Product Synonym Gene Name
AKAP95
Product Synonym Names
AKAP8; AKAP95; DKFZp586B1222; A kinase (PRKA) anchor protein 8; A kinase anchor protein 95; A-kinase anchor protein 8; A-kinase anchor protein, 95kDa; AKAP8 antibody; AKAP95 antibody; DKFZp586B1222 antibody; A kinase (PRKA) anchor protein 8 antibody; A kinase anchor protein 95 antibody; A-kinase anchor protein 8 antibody; A-kinase anchor protein; 95kDa antibody; AKAP8 / AKAP95
Immunogen Sequence
DQGYGGYGAW SAG
Clonality
Polyclonal
Host
Goat
Species Reactivity
Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Cow
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration
100ug specific antibody in 200ul (lot specific)
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
Antibody/Peptide Pairs
AKAP8 / AKAP95 peptide (MBS426517) is used for blocking the activity of AKAP8/AKAP95 antibody (MBS420061)
Molecular Weight
76,108 Da
OMIM
604692
Immunogen
Peptide with sequence DQGYGGYGAWSAG-C, from the N Terminus of the protein sequence according to NP_005849.1.
Epitope
N Terminus
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Applications Tested/Suitable for anti-AKAP8 antibody
Peptide ELISA (EIA), Western Blot (WB)
Application Notes for anti-AKAP8 antibody
Peptide ELISA: Antibody detection limit dilution 1: 32000.
Western Blot: Experiments gave a band at approx 100kDa in Human Liver lysate after 1ug/ml antibody staining. This band corresponds to the 95kDa band reported in literature (PMID: 10601332). This protein has a calculated MW of 76.1kDa according to NP_005849. Recommended concentration: 1-3ug/ml.

Western Blot (WB) of anti-AKAP8 antibody

Staining (1ug/ml) of Human Liver lysate (RIPA buffer, 35ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
Goat Anti-AKAP8 Polyclonal Antibody – Cat# MBS420061

Other Notes

Small volumes of anti-AKAP8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for AKAP8. It may not necessarily be applicable to this product.

NCBI GI #
5031579
NCBI GeneID
10270
NCBI Accession #
NP_005849.1
UniProt Related Accession #
O43823
GenBank Nucleotide #
NM_005858.3
NCBI Official Full Name
A-kinase anchor protein 8
NCBI Official Synonym Full Names
A-kinase anchoring protein 8
NCBI Official Symbol
AKAP8
NCBI Official Synonym Symbols
AKAP-8; AKAP95; AKAP 95; AKAP-95
UniProt Protein Name
A-kinase anchor protein 8
UniProt Synonym Protein Names
A-kinase anchor protein 95 kDa; AKAP 95
Protein Family
A-kinase anchor protein
UniProt Gene Name
AKAP8
UniProt Synonym Gene Names
AKAP95; AKAP-8; AKAP 95
UniProt Entry Name
AKAP8_HUMAN
NCBI Protein Information
A-kinase anchor protein 8

NCBI Summary for AKAP8

This gene encodes a member of the A-kinase anchor protein family. A-kinase anchor proteins are scaffold proteins that contain a binding domain for the RI/RII subunit of protein kinase A (PKA) and recruit PKA and other signaling molecules to specific subcellular locations. This gene encodes a nuclear A-kinase anchor protein that binds to the RII alpha subunit of PKA and may play a role in chromosome condensation during mitosis by targeting PKA and the condensin complex to chromatin. A pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, May 2011]
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UniProt Comments for AKAP8

AKAP8: Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II). Belongs to the AKAP95 family.

Protein type: Cell cycle regulation; Mitochondrial; Adaptor/scaffold; RNA-binding

Chromosomal Location of Human Ortholog: 19p13.1

Cellular Component: condensed chromosome; female pronucleus; Golgi apparatus; membrane; mitochondrion; nuclear matrix; nucleolus; nucleoplasm; nucleus

Molecular Function: DEAD/H-box RNA helicase binding; double-stranded DNA binding; histone deacetylase binding; protein binding; zinc ion binding

Biological Process: innate immune response; mitosis; mitotic chromosome condensation; positive regulation of histone deacetylation; protein transport; regulation of histone phosphorylation; regulation of transcription, DNA-dependent; signal transduction; transcription, DNA-dependent
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Research Articles on AKAP8

1. Gene dosage at 19p13.12, and AKAP8 and/or AKAP8L in particular, play an important role in modulation of head size and may contribute to autism risk.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-AKAP8 antibody

 Products by Pathway  Pathway Diagram
 G Protein Signaling Pathways antibodies  G Protein Signaling Pathways Diagram
 TNF-alpha/NF-kB Signaling Pathway antibodies  TNF-alpha/NF-kB Signaling Pathway Diagram

Diseases associated with anti-AKAP8 antibody

 Disease Name  Pubmed Publications
 Lung Neoplasms Antibodies  >2 publications with AKAP8 and Lung Neoplasms
 Neoplasm Metastasis Antibodies  >1 publications with AKAP8 and Neoplasm Metastasis
 Adenocarcinoma Antibodies  >1 publications with AKAP8 and Adenocarcinoma
 Carcinoma Antibodies  >1 publications with AKAP8 and Carcinoma
 Inflammation Antibodies  >1 publications with AKAP8 and Inflammation
 Necrosis Antibodies  >1 publications with AKAP8 and Necrosis

Organs/Tissues associated with anti-AKAP8 antibody

 Organ/Tissue Name  Pubmed Publications
 Lymph Node Antibodies  >3 publications with AKAP8 and Lymph Node
 Brain Antibodies  >3 publications with AKAP8 and Brain
 Lung Antibodies  >2 publications with AKAP8 and Lung
 Pancreas Antibodies  >1 publications with AKAP8 and Pancreas
 Ovary Antibodies  >1 publications with AKAP8 and Ovary
 Thyroid Antibodies  >1 publications with AKAP8 and Thyroid
 Mouth Antibodies  >1 publications with AKAP8 and Mouth
 Liver Antibodies  >1 publications with AKAP8 and Liver
 Kidney Antibodies  >1 publications with AKAP8 and Kidney
 Blood Antibodies  >1 publications with AKAP8 and Blood
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