WHIP/WRNIP1 (WRNIP1) Antibody – Goat Polyclonal

Werner's syndrome is a rare autosomal recessive disorder characterized by accelerated aging that is caused by defects in the Werner syndrome ATP-dependent helicase gene (WRN). The protein encoded by this gene interacts with the exonuclease-containing N-terminal portion of the Werner protein. This protein has a ubiquitin-binding zinc-finger domain in the N-terminus, an ATPase domain, and two leucine zipper motifs in the C-terminus. It has sequence similarity to replication factor C family proteins and is conserved from E. coli to human. This protein likely accumulates at sites of DNA damage by interacting with polyubiquinated proteins and also binds to DNA polymerase delta and increases the initiation frequency of DNA polymerase delta-mediated DNA synthesis. This protein also interacts with nucleoporins at nuclear pore complexes. Two transcript variants encoding different isoforms have been isolated for this gene. [provided by RefSeq, Jul 2012]

WRNIP1: a modulator for initiation or restart of DNA polymerase delta-mediated DNA synthesis. Its ATPase activity may sense DNA ends and regulate the extent of polymerase stimulation.

Protein type: Helicase; EC 3.6.1.3

Chromosomal Location of Human Ortholog: 6p25.2

Cellular Component: membrane; nuclear chromosome, telomeric region; nucleus; perinuclear region of cytoplasm

Molecular Function: ATP binding; ATPase activity; DNA binding; identical protein binding; metal ion binding; protein binding

Biological Process: DNA replication; DNA synthesis during DNA repair; regulation of DNA replication initiation