SOX8 Antibody – Goat Polyclonal

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein may be involved in brain development and function. Haploinsufficiency for this protein may contribute to the mental retardation found in haemoglobin H-related mental retardation (ART-16 syndrome). [provided by RefSeq, Jul 2008]

SOX8: May play a role in central nervous system, limb and facial development. May be involved in male sex determination. Binds the consensus motif 5'-[AT][AT]CAA[AT]G-3'.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: cytoplasm; nucleus

Molecular Function: DNA binding; protein heterodimerization activity; transcription factor binding

Biological Process: astrocyte fate commitment; cell fate commitment; cell maturation; enteric nervous system development; fat cell differentiation; in utero embryonic development; male gonad development; negative regulation of apoptosis; negative regulation of myoblast differentiation; negative regulation of photoreceptor cell differentiation; negative regulation of transcription, DNA-dependent; neural crest cell migration; oligodendrocyte differentiation; osteoblast differentiation; peripheral nervous system development; positive regulation of gliogenesis; positive regulation of osteoblast proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; retina development in camera-type eye; Sertoli cell development; signal transduction; spermatogenesis; transcription, DNA-dependent