VPS29 Antibody – Goat Polyclonal

This gene belongs to a group of vacuolar protein sorting (VPS) genes that, when functionally impaired, disrupt the efficient delivery of vacuolar hydrolases. The protein encoded by this gene is a component of a large multimeric complex, termed the retromer complex, which is involved in retrograde transport of proteins from endosomes to the trans-Golgi network. This VPS protein may be involved in the formation of the inner shell of the retromer coat for retrograde vesicles leaving the prevacuolar compartment. Alternative splice variants encoding different isoforms and representing non-protein coding transcripts have been found for this gene. [provided by RefSeq, Aug 2013]

VPS29: Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Has low protein phosphatase activity towards a serine-phosphorylated peptide derived from IGF2R (in vitro). Belongs to the VPS29 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Vesicle; EC 3.1.3.3; Protein phosphatase, Ser/Thr (non-receptor)

Chromosomal Location of Human Ortholog: 12q24

Cellular Component: cytoplasm; cytosol; early endosome; endosome; endosome membrane; intracellular membrane-bound organelle; late endosome; retromer complex

Molecular Function: metal ion binding; protein binding; protein transporter activity

Biological Process: intracellular protein transport; retrograde transport, endosome to Golgi; Wnt receptor signaling pathway