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RAE1 Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS420468

MBS420468 is an antibody targeting RAE1. Also known as Goat anti-RAE1 Antibody. Reactive in Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Pig, Dog, Cow. Host: Goat. More details

$450 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
RAE1, Polyclonal Antibody
Full Product Name
Goat anti-RAE1 Antibody
Product Gene Name
anti-RAE1 antibody
Product Synonym Names
RAE1; RAE1 RNA export 1 homolog (S. pombe); HGNC: 9828; FLJ30608; MIG14; MRNP41; Mnrp41; dJ481F12.3; dJ800J21.1; RAE1 (RNA export 1, S. pombe) homolog; homolog of yeast Rae1 (Bharathi) mRNA-associated protein of 41 kDa (Kraemer); mRNA export protein; mRNA-; RAE1 antibody; RAE1 RNA export 1 homolog (S. pombe) antibody; HGNC: 9828 antibody; FLJ30608 antibody; MIG14 antibody; MRNP41 antibody; Mnrp41 antibody; dJ481F12.3 antibody; dJ800J21.1 antibody; RAE1 (RNA export 1; S. pombe) homolog antibody; homolog of yeast Rae1 (Bharathi) mRNA-associated protein of 41 kDa (Kraemer) antibody; mRNA export protein antibody; mRNA-associated protein MRNP 41 antibody; mRNA-binding protein; 41-kD antibody; migration-inducing gene 14 antibody; RP4-800J21.2 antibody; MGC117333 antibody; MGC126076 antibody; MGC126077 antibody; OTTHUMP00000166110 antibody
Immunogen Sequence
NAAEELKPRN KK
Clonality
Polyclonal
Host
Goat
Species Reactivity
Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Pig, Dog, Cow
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration
100ug specific antibody in 200ul (lot specific)
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
Antibody/Peptide Pairs
RAE1 peptide (MBS425146) is used for blocking the activity of RAE1 antibody (MBS420468)
Molecular Weight
40,968 Da
OMIM
603343
Immunogen
Peptide with sequence C-NAAEELKPRNKK, from the C Terminus of the protein sequence according to NP_003601.1; NP_001015885.1.
Epitope
C Terminus
Note
NP_003601and NP_001015885 represent identical proteins.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Applications Tested/Suitable for anti-RAE1 antibody
Peptide ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-RAE1 antibody
Peptide ELISA: Antibody detection limit dilution 1: 64000.
Immunohistochemistry: In paraffin embedded Human Brain Cortex shows staining of neuronal cell bodies. Recommended concentration, 3-6ug/ml.
Western Blot: Approx 40kDa band observed in lysates cell lines HepG2, HeLa, Jurkat and MCF7 (calculated MW of 41. 0kDa according to NP_003601.1). Recommended concentration: 0.1-0.3ug/ml.

Western Blot (WB) of anti-RAE1 antibody

(0.1ug/ml) staining of HepG2 (A), HeLa (B), Jurkat (C) and MCF7 (D) lysates (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Goat Anti-RAE1 Polyclonal Antibody – Cat# MBS420468

Immunohistochemistry (IHC) of anti-RAE1 antibody

(3.8ug/ml) staining of paraffin embedded Human Brain Cortex. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
Goat Anti-RAE1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS420468

Other Notes

Small volumes of anti-RAE1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for RAE1. It may not necessarily be applicable to this product.

NCBI GI #
4506399
NCBI GeneID
8480
NCBI Accession #
NP_003601.1
NCBI Related Accession #
NP_001015885.1
UniProt Secondary Accession #
O15306; Q3SYL7; Q5TCH8; Q6V708; Q9H100; Q9NQM6; A8K882
UniProt Related Accession #
P78406
GenBank Nucleotide #
NM_003610.3
NCBI Official Full Name
mRNA export factor
NCBI Official Synonym Full Names
ribonucleic acid export 1
NCBI Official Symbol
RAE1
NCBI Official Synonym Symbols
MIG14; MRNP41; Mnrp41; dJ481F12.3; dJ800J21.1
UniProt Protein Name
mRNA export factor
UniProt Synonym Protein Names
Rae1 protein homolog; mRNA-associated protein mrnp 41
Protein Family
Poly(A)+ RNA export protein
UniProt Gene Name
RAE1
UniProt Synonym Gene Names
MRNP41
UniProt Entry Name
RAE1L_HUMAN
NCBI Protein Information
mRNA export factor

NCBI Summary for RAE1

Mutations in the Schizosaccharomyces pombe Rae1 and Saccharomyces cerevisiae Gle2 genes have been shown to result in accumulation of poly(A)-containing mRNA in the nucleus, suggesting that the encoded proteins are involved in RNA export. The protein encoded by this gene is a homolog of yeast Rae1. It contains four WD40 motifs, and has been shown to localize to distinct foci in the nucleoplasm, to the nuclear rim, and to meshwork-like structures throughout the cytoplasm. This gene is thought to be involved in nucleocytoplasmic transport, and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
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UniProt Comments for RAE1

RAE1: Binds mRNA. May function in nucleocytoplasmic transport and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton. Belongs to the WD repeat rae1 family.

Protein type: Motility/polarity/chemotaxis; RNA-binding

Chromosomal Location of Human Ortholog: 20q13.31

Cellular Component: cytoplasm; nuclear envelope; nuclear pore; nucleolus; nucleus

Molecular Function: microtubule binding; RNA binding; ubiquitin binding

Biological Process: mitotic nuclear envelope disassembly; mRNA export from nucleus; protein import into nucleus; protein sumoylation; RNA-mediated gene silencing; tRNA export from nucleus; viral reproduction; viral transcription
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Research Articles on RAE1

1. Vesiculoviral matrix (M) protein occupies nucleic acid binding site at nucleoporin pair (Rae1 * Nup98).

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-RAE1 antibody

 Reference Product  PubMed Publications
 NUP98 antibody  >29 publications with RAE1 and NUP98
 NXF1 antibody  >5 publications with RAE1 and NXF1
 NUP214 antibody  >3 publications with RAE1 and NUP214
 NUP88 antibody  >3 publications with RAE1 and NUP88
 NUP62 antibody  >1 publications with RAE1 and NUP62

Pathways associated with anti-RAE1 antibody

 Products by Pathway  Pathway Diagram
 Antiviral Mechanism By IFN-stimulated Genes Pathway antibodies  Antiviral Mechanism By IFN-stimulated Genes Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Cellular Response To Heat Stress Pathway antibodies  Cellular Response To Heat Stress Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Export Of Viral Ribonucleoproteins From Nucleus Pathway antibodies  Export Of Viral Ribonucleoproteins From Nucleus Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Gene Silencing By RNA Pathway antibodies  Gene Silencing By RNA Pathway Diagram

Diseases associated with anti-RAE1 antibody

 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >13 publications with RAE1 and Disease Models, Animal
 Liver Diseases Antibodies  >6 publications with RAE1 and Liver Diseases
 Necrosis Antibodies  >6 publications with RAE1 and Necrosis
 Neoplasms, Experimental Antibodies  >5 publications with RAE1 and Neoplasms, Experimental
 Kidney Diseases Antibodies  >3 publications with RAE1 and Kidney Diseases
 Nervous System Diseases Antibodies  >3 publications with RAE1 and Nervous System Diseases
 Genital Diseases, Male Antibodies  >3 publications with RAE1 and Genital Diseases, Male
 Prostatic Diseases Antibodies  >2 publications with RAE1 and Prostatic Diseases
 Prostatic Neoplasms Antibodies  >2 publications with RAE1 and Prostatic Neoplasms
 Drug-Induced Liver Injury Antibodies  >2 publications with RAE1 and Drug-Induced Liver Injury

Organs/Tissues associated with anti-RAE1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >48 publications with RAE1 and Blood
 Liver Antibodies  >9 publications with RAE1 and Liver
 Brain Antibodies  >6 publications with RAE1 and Brain
 Kidney Antibodies  >5 publications with RAE1 and Kidney
 Pancreas Antibodies  >4 publications with RAE1 and Pancreas
 Bone Antibodies  >4 publications with RAE1 and Bone
 Bone Marrow Antibodies  >4 publications with RAE1 and Bone Marrow
 Skin Antibodies  >4 publications with RAE1 and Skin
 Salivary Gland Antibodies  >3 publications with RAE1 and Salivary Gland
 Lung Antibodies  >3 publications with RAE1 and Lung
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