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SRD5A1 Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS420692

MBS420692 is an antibody targeting SRD5A1. Also known as Goat anti-SRD5A1/5-alpha reductase 1 Antibody. Reactive in Tested: Human; Expected from sequence similarity: Human. Host: Goat. More details

$450 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
SRD5A1/5-alpha reductase 1, Polyclonal Antibody
Full Product Name
Goat anti-SRD5A1/5-alpha reductase 1 Antibody
Product Gene Name
anti-SRD5A1 antibody
Product Synonym Names
Goat Anti-SRD5A1 Antibody; SRD5A1; steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1); 5-alpha reductase; steroid 5-alpha-reductase type I; 3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1; steroid-5-alpha-reductase 1; SRD5A1 antibody; steroid-5-alpha-reductase; alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) antibody; 5-alpha reductase antibody; steroid 5-alpha-reductase type I antibody; 3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1 antibody; steroid-5-alpha-reductase 1 antibody; 5-alpha reductase 1; SRD5A1 / 5-alpha reductase 1
Immunogen Sequence
ATATGVAEER LLC
Clonality
Polyclonal
Host
Goat
Species Reactivity
Tested: Human; Expected from sequence similarity: Human
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration
100ug specific antibody in 200ul (lot specific)
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
Antibody/Peptide Pairs
SRD5A1 / 5-alpha reductase 1 peptide (MBS428042) is used for blocking the activity of SRD5A1/5-alpha reductase 1 antibody (MBS420692)
Molecular Weight
29,459 Da
OMIM
184753
Immunogen
Peptide with sequence ATATGVAEERLLC, from the N Terminus of the protein sequence according to NP_001038.1.
Epitope
N Terminus
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Applications Tested/Suitable for anti-SRD5A1 antibody
Peptide ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-SRD5A1 antibody
Peptide ELISA: Antibody detection limit dilution 1: 64000.
Immunohistochemistry: In paraffin embedded Human Prostate shows reticulate staining in the cytoplasm of secretory cells in the gland. Recommended concentration, 4-6ug/ml.

Immunohistochemistry (IHC) of anti-SRD5A1 antibody

(4ug/ml) staining of paraffin embedded Human Prostate. Steamed antigen retrieval with Tris/EDTA buffer pH 9, HRP-staining.
Goat Anti-SRD5A1 Polyclonal Antibody – Cat# MBS420692

Other Notes

Small volumes of anti-SRD5A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SRD5A1. It may not necessarily be applicable to this product.

NCBI GI #
4507201
NCBI GeneID
6715
NCBI Accession #
NP_001038.1
UniProt Secondary Accession #
Q9UHY4; Q9UP36; Q9UP37; B2R7Q1
UniProt Related Accession #
P18405
GenBank Nucleotide #
NM_001047.3
NCBI Official Full Name
3-oxo-5-alpha-steroid 4-dehydrogenase 1 isoform 1
NCBI Official Synonym Full Names
steroid 5 alpha-reductase 1
NCBI Official Symbol
SRD5A1
NCBI Official Synonym Symbols
S5AR 1
UniProt Protein Name
3-oxo-5-alpha-steroid 4-dehydrogenase 1
UniProt Synonym Protein Names
SR type 1; Steroid 5-alpha-reductase 1; S5AR 1
Protein Family
3-oxo-5-alpha-steroid 4-dehydrogenase
UniProt Gene Name
SRD5A1
UniProt Synonym Gene Names
S5AR 1
UniProt Entry Name
S5A1_HUMAN
NCBI Protein Information
3-oxo-5-alpha-steroid 4-dehydrogenase 1

NCBI Summary for SRD5A1

Steroid 5-alpha-reductase (EC 1.3.99.5) catalyzes the conversion of testosterone into the more potent androgen, dihydrotestosterone (DHT). Also see SRD5A2 (MIM 607306).[supplied by OMIM, Mar 2008]

UniProt Comments for SRD5A1

SRD5A1: Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5- alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology. Belongs to the steroid 5-alpha reductase family.

Protein type: Membrane protein, integral; EC 1.3.1.22; Membrane protein, multi-pass; Lipid Metabolism - androgen and estrogen; Oxidoreductase

Chromosomal Location of Human Ortholog: 5p15

Cellular Component: cell soma; endoplasmic reticulum membrane; integral to membrane; myelin sheath; perinuclear region of cytoplasm

Molecular Function: 3-oxo-5-alpha-steroid 4-dehydrogenase activity; amide binding; cholestenone 5-alpha-reductase activity; electron carrier activity

Biological Process: androgen biosynthetic process; cell differentiation; cellular response to insulin stimulus; cellular response to starvation; cerebral cortex development; circadian sleep/wake cycle, REM sleep; diterpenoid metabolic process; female genitalia development; hippocampus development; hypothalamus development; liver development; male genitalia development; male gonad development; pituitary gland development; progesterone metabolic process; response to drug; response to follicle-stimulating hormone stimulus; response to muscle activity; serotonin metabolic process; sex determination; spinal cord development; thalamus development; urogenital system development
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Research Articles on SRD5A1

1. the genotypic distribution of 22 single nucleotide polymorphisms in SRD5A1 and SRD5A2 in a set of Spanish prostate cancer patients, were evaluated.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SRD5A1 antibody

 Reference Product  PubMed Publications
 CYP17A1 antibody  >27 publications with SRD5A1 and CYP17A1
 HSD3B1 antibody  >25 publications with SRD5A1 and HSD3B1
 CYP19A1 antibody  >21 publications with SRD5A1 and CYP19A1
 HSD17B3 antibody  >14 publications with SRD5A1 and HSD17B3
 HSD17B2 antibody  >13 publications with SRD5A1 and HSD17B2
 HSD3B2 antibody  >11 publications with SRD5A1 and HSD3B2
 SRD5A3 antibody  >11 publications with SRD5A1 and SRD5A3
 HSD17B6 antibody  >4 publications with SRD5A1 and HSD17B6
 AKR1D1 antibody  >3 publications with SRD5A1 and AKR1D1
 UGT2B17 antibody  >2 publications with SRD5A1 and UGT2B17

Pathways associated with anti-SRD5A1 antibody

 Products by Pathway  Pathway Diagram
 Androgen Biosynthesis Pathway antibodies  Androgen Biosynthesis Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Metabolism Of Steroid Hormones Pathway antibodies  Metabolism Of Steroid Hormones Pathway Diagram
 Steroid Hormone Biosynthesis Pathway antibodies  Steroid Hormone Biosynthesis Pathway Diagram
 Steroid Hormone Biosynthesis Pathway antibodies  Steroid Hormone Biosynthesis Pathway Diagram
 Allopregnanolone Biosynthesis Pathway antibodies  Allopregnanolone Biosynthesis Pathway Diagram
 Allopregnanolone Biosynthesis Pathway antibodies  Allopregnanolone Biosynthesis Pathway Diagram
 Androgen Biosynthesis Pathway antibodies  Androgen Biosynthesis Pathway Diagram
 Androgen Biosynthesis Pathway antibodies  Androgen Biosynthesis Pathway Diagram

Diseases associated with anti-SRD5A1 antibody

 Disease Name  Pubmed Publications
 Prostatic Neoplasms Antibodies  >35 publications with SRD5A1 and Prostatic Neoplasms
 Adenocarcinoma Antibodies  >8 publications with SRD5A1 and Adenocarcinoma
 Carcinoma Antibodies  >8 publications with SRD5A1 and Carcinoma
 Breast Neoplasms Antibodies  >8 publications with SRD5A1 and Breast Neoplasms
 Cardiovascular Diseases Antibodies  >7 publications with SRD5A1 and Cardiovascular Diseases
 Polycystic Ovary Syndrome Antibodies  >7 publications with SRD5A1 and Polycystic Ovary Syndrome
 Hyperplasia Antibodies  >6 publications with SRD5A1 and Hyperplasia
 Neoplasm Metastasis Antibodies  >6 publications with SRD5A1 and Neoplasm Metastasis
 Neoplasms, Experimental Antibodies  >6 publications with SRD5A1 and Neoplasms, Experimental
 Disease Models, Animal Antibodies  >6 publications with SRD5A1 and Disease Models, Animal

Organs/Tissues associated with anti-SRD5A1 antibody

 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >51 publications with SRD5A1 and Prostate
 Blood Antibodies  >34 publications with SRD5A1 and Blood
 Ovary Antibodies  >17 publications with SRD5A1 and Ovary
 Testis Antibodies  >13 publications with SRD5A1 and Testis
 Brain Antibodies  >13 publications with SRD5A1 and Brain
 Liver Antibodies  >12 publications with SRD5A1 and Liver
 Muscle Antibodies  >11 publications with SRD5A1 and Muscle
 Uterus Antibodies  >7 publications with SRD5A1 and Uterus
 Bone Antibodies  >7 publications with SRD5A1 and Bone
 Embryonic Tissue Antibodies  >6 publications with SRD5A1 and Embryonic Tissue
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