CPT1A Antibody – Goat Polyclonal

The mitochondrial oxidation of long-chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase I (which is located in the outer membrane and is detergent-labile) and carnitine palmitoyltransferase II (which is located in the inner membrane and is detergent-stable), together with a carnitine-acylcarnitine translocase. CPT I is the key enzyme in the carnitine-dependent transport across the mitochondrial inner membrane and its deficiency results in a decreased rate of fatty acid beta-oxidation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

CPT1A: Belongs to the carnitine/choline acetyltransferase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Lipid Metabolism - fatty acid; EC 2.3.1.21; Mitochondrial; Transferase

Chromosomal Location of Human Ortholog: 11q13.2

Cellular Component: integral to mitochondrial outer membrane; membrane; mitochondrial inner membrane; mitochondrial outer membrane; mitochondrion

Molecular Function: carnitine O-palmitoyltransferase activity; identical protein binding

Biological Process: carnitine metabolic process; carnitine shuttle; circadian rhythm; eating behavior; epithelial cell differentiation; fatty acid beta-oxidation; glucose metabolic process; long-chain fatty acid metabolic process; positive regulation of fatty acid beta-oxidation; protein homooligomerization; regulation of insulin secretion; response to drug; response to organic cyclic substance; triacylglycerol metabolic process

Disease: Carnitine Palmitoyltransferase I Deficiency