ADAM12 Antibody – Goat Polyclonal

This gene encodes a member of a family of proteins that are structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Expression of this gene has been used as a maternal serum marker for pre-natal development. Alternative splicing results in multiple transcript variants encoding different isoforms. Shorter isoforms are secreted, while longer isoforms are membrane-bound form. [provided by RefSeq, Jan 2014]

ADAM12: contains a disintegrin and metalloprotease (ADAM) domain 12, which is a member of the ADAM protein family. Involved in skeletal muscle regeneration, specifically at the onset of cell fusion, and the differentiation of macrophage-derived giant cells (MGC) and osteoclasts. 2 alternative splicing isoforms have been described: a shorter secreted form and a longer membrane-bound form. The shorter form stimulates myogenesis.

Protein type: Protease; Motility/polarity/chemotaxis; Membrane protein, integral; EC 3.4.24.-

Chromosomal Location of Human Ortholog: 10q26

Cellular Component: extracellular region; integral to membrane; mitochondrion; nucleoplasm; plasma membrane

Molecular Function: metalloendopeptidase activity; metallopeptidase activity; protein binding; SH3 domain binding; zinc ion binding

Biological Process: cell adhesion; myoblast fusion; proteolysis