Myosin IXB (MYO9B) Antibody – Goat Polyclonal

This gene encodes a member of the myosin family of actin-based molecular motor heavy chain proteins. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-9 (MYH9). The protein has four IQ motifs located in the neck domain that bind calmodulin, which serves as a light chain. The protein complex has a single-headed structure and exhibits processive movement on actin filaments toward the minus-end. The protein also has rho-GTPase activity. Polymorphisms in this gene are associated with celiac disease and ulcerative colitis susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

MYO9B: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. May be involved in the remodeling of the actin cytoskeleton. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions. Also acts as a GTPase activating protein on Rho. Genetic variation in MYO9B is the cause of susceptibility to celiac disease type 4 (CELIAC4). It is a multifactorial disorder of the small intestine that is influenced by both environmental and genetic factors. It is characterized by malabsorption resulting from inflammatory injury to the mucosa of the small intestine after the ingestion of wheat gluten or related rye and barley proteins. In its classic form, celiac disease is characterized in children by malabsorption and failure to thrive. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: GAPs, Rac/Rho; Actin-binding; Motility/polarity/chemotaxis; Motor; GAPs

Chromosomal Location of Human Ortholog: 19p13.1

Cellular Component: actin cytoskeleton; actin filament; cell cortex; cytoplasm; cytosol; lamellipodium; membrane; myosin complex; perinuclear region of cytoplasm; ruffle

Molecular Function: actin binding; actin filament binding; actin-dependent ATPase activity; ADP binding; ATP binding; ATP-dependent protein binding; ATPase activity; calmodulin binding; GTPase activator activity; microfilament motor activity; protein binding; protein homodimerization activity; Rho GTPase binding; Roundabout binding; zinc ion binding

Biological Process: actin filament-based movement; ARF protein signal transduction; metabolic process; positive regulation of GTPase activity; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction; Rho protein signal transduction

Disease: Celiac Disease, Susceptibility To, 4