Aurora Kinase A/AURKA (AURKA) Antibody – Goat Polyclonal

The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

AurA: a member of the AUR family of kinases. A cell cycle-regulated serine/threonine protein kinase that is overexpressed in many tumor cell lines. Regulated by phosphorylation-dependent proteasomal degradation. Localized to mitotic centrosomes and spindle microtubules and is required for centrosome maturation. Loss of Aurora A leads to defective mitotic spindles and gross errors in chromosome segregation. Required for centrosome duplication and chromosome segregation. Overexpression in culture drives transformation and aneuploidy, and negatively regulates p53. Amplified or overexpressed in many tumors or cell lines. Found as a skin tumor susceptibility gene in mouse, and a human SNP in a degradation domain is weakly cancer-associated and undergoes allele-specific amplification. Inhibitors: VX-680, ZM447439, Hesperadin, SNS-595.

Protein type: Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Protein kinase, Other; EC 2.7.11.1; Other group; AUR family

Chromosomal Location of Human Ortholog: 20q13

Cellular Component: axon hillock; centriole; centrosome; cilium; condensed nuclear chromosome, pericentric region; cytosol; germinal vesicle; microtubule cytoskeleton; midbody; nucleoplasm; nucleus; perinuclear region of cytoplasm; pronucleus; spindle; spindle microtubule; spindle midzone; spindle pole centrosome

Molecular Function: ATP binding; histone serine kinase activity; protein binding; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; ubiquitin protein ligase binding

Biological Process: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; anterior/posterior axis specification; cell division; centrosome localization; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; G2/M transition of mitotic cell cycle; mitosis; mitotic centrosome separation; mitotic spindle organization and biogenesis; negative regulation of apoptosis; negative regulation of protein binding; positive regulation of mitosis; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein amino acid autophosphorylation; protein amino acid phosphorylation; protein ubiquitination during ubiquitin-dependent protein catabolic process; regulation of centrosome cycle; regulation of cytokinesis; regulation of protein stability; response to estradiol stimulus; spindle assembly involved in female meiosis I; spindle organization and biogenesis

Disease: Colorectal Cancer