COX1/PTGS1 (PTGS1) Antibody – Goat Polyclonal

This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclooxygenase and as a peroxidase, the encoded protein has been identified as a moonlighting protein. The protein may promote cell proliferation during tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

COX-1: May play an important role in regulating or promoting cell proliferation in some normal and neoplastically transformed cells. Homodimer. Belongs to the prostaglandin G/H synthase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Lipid Metabolism - arachidonic acid; EC 1.14.99.1; Oxidoreductase

Chromosomal Location of Human Ortholog: 9q32-q33.3

Cellular Component: cytoplasm; endoplasmic reticulum membrane; Golgi apparatus; intracellular membrane-bound organelle; nuclear envelope; nucleus; photoreceptor outer segment

Molecular Function: dioxygenase activity; heme binding; lipid binding; metal ion binding; peroxidase activity; prostaglandin-endoperoxide synthase activity

Biological Process: aging; cyclooxygenase pathway; inflammatory response; learning; lipid metabolic process; memory; negative regulation of epinephrine secretion; positive regulation of smooth muscle contraction; positive regulation of vasoconstriction; prostaglandin biosynthetic process; regulation of blood pressure; regulation of cell proliferation; response to corticosterone stimulus; response to organic nitrogen; response to oxidative stress; sensory perception of pain; xenobiotic metabolic process