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AGR2 Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS421163

MBS421163 is an antibody targeting AGR2. Also known as Goat anti-AGR2 Antibody. Reactive in Tested: Human; Expected from sequence similarity: Human, Mouse, Dog. Host: Goat. More details

$450 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
AGR2, Polyclonal Antibody
Full Product Name
Goat anti-AGR2 Antibody
Product Gene Name
anti-AGR2 antibody
Product Synonym Names
AGR2; anterior gradient 2 homolog (Xenopus laevis); AG2; GOB-4; HAG-2; XAG-2; anterior gradient 2 homolog; anterior gradient 2 homolog (Xenepus laevis); secreted cement gland homolog; AGR2 antibody; anterior gradient 2 homolog (Xenopus laevis) antibody; AG2 antibody; GOB-4 antibody; HAG-2 antibody; XAG-2 antibody; anterior gradient 2 homolog antibody; anterior gradient 2 homolog (Xenepus laevis) antibody; secreted cement gland homolog antibody
Immunogen Sequence
GAKKDTKDSR PK
Clonality
Polyclonal
Host
Goat
Species Reactivity
Tested: Human; Expected from sequence similarity: Human, Mouse, Dog
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration
100ug specific antibody in 200ul (lot specific)
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
Antibody/Peptide Pairs
AGR2 peptide (MBS426063) is used for blocking the activity of AGR2 antibody (MBS421163)
Molecular Weight
19,979 Da
OMIM
606358
Immunogen
Peptide with sequence C-GAKKDTKDSRPK, from the internal region of the protein sequence according to NP_006399.1.
Epitope
Internal region
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Applications Tested/Suitable for anti-AGR2 antibody
Peptide ELISA (EIA), Western Blot (WB)
Application Notes for anti-AGR2 antibody
Peptide ELISA: Antibody detection limit dilution 1: 128000.
Western Blot: Approx 17-18kDa band observed in Human Colon, Duodenum and Lung lysates (calculated MW of 20. 0kDa according to NP_006399.1). Recommended concentration: up to 0. 01ug/ml.

Western Blot (WB) of anti-AGR2 antibody

(0.01ug/ml) staining of Human Colon lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Goat Anti-AGR2 Polyclonal Antibody – Cat# MBS421163

Other Notes

Small volumes of anti-AGR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for AGR2. It may not necessarily be applicable to this product.

NCBI GI #
5453541
NCBI GeneID
10551
NCBI Accession #
NP_006399.1
UniProt Related Accession #
O95994
GenBank Nucleotide #
NM_006408.3
NCBI Official Full Name
anterior gradient protein 2 homolog
NCBI Official Synonym Full Names
anterior gradient 2, protein disulphide isomerase family member
NCBI Official Symbol
AGR2
NCBI Official Synonym Symbols
AG2; GOB-4; HAG-2; XAG-2; PDIA17; HEL-S-116
UniProt Protein Name
Anterior gradient protein 2 homolog
UniProt Synonym Protein Names
HPC8; Secreted cement gland protein XAG-2 homolog
Protein Family
Anterior gradient protein
UniProt Gene Name
AGR2
UniProt Synonym Gene Names
AG2; AG-2; hAG-2
UniProt Entry Name
AGR2_HUMAN
NCBI Protein Information
anterior gradient protein 2 homolog

UniProt Comments for AGR2

AGR2: Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells. Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth. Interacts with LYPD3 and DAG1 (alphaDAG1). Interacts with MUC2; disulfide-linked. Expressed strongly in trachea, lung, stomach, colon, prostate and small intestine. Expressed weakly in pituitary gland, salivary gland, mammary gland, bladder, appendix, ovary, fetal lung, uterus, pancreas, kidney, fetal kidney, testis, placenta, thyroid gland and in estrogen receptor (ER)-positive breast cancer cell lines. Belongs to the AGR family.

Protein type: Secreted, signal peptide; Secreted; Oncoprotein

Chromosomal Location of Human Ortholog: 7p21.3

Cellular Component: endoplasmic reticulum; extracellular space; mitochondrion

Molecular Function: epidermal growth factor receptor binding; protein binding; protein homodimerization activity

Biological Process: digestive tract morphogenesis; positive regulation of developmental growth; positive regulation of epidermal growth factor receptor signaling pathway
Show more

Research Articles on AGR2

1. analysis of molecular characteristics, function, and regulation of AGR2 in cancer[review]

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-AGR2 antibody

 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >63 publications with AGR2 and Carcinoma
 Neoplasm Metastasis Antibodies  >43 publications with AGR2 and Neoplasm Metastasis
 Adenocarcinoma Antibodies  >42 publications with AGR2 and Adenocarcinoma
 Breast Neoplasms Antibodies  >35 publications with AGR2 and Breast Neoplasms
 Prostatic Neoplasms Antibodies  >19 publications with AGR2 and Prostatic Neoplasms
 Lung Diseases Antibodies  >15 publications with AGR2 and Lung Diseases
 Neoplasm Invasiveness Antibodies  >13 publications with AGR2 and Neoplasm Invasiveness
 Lung Neoplasms Antibodies  >10 publications with AGR2 and Lung Neoplasms
 Inflammation Antibodies  >10 publications with AGR2 and Inflammation
 Carcinoma, Squamous Cell Antibodies  >10 publications with AGR2 and Carcinoma, Squamous Cell

Organs/Tissues associated with anti-AGR2 antibody

 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >32 publications with AGR2 and Prostate
 Lung Antibodies  >23 publications with AGR2 and Lung
 Intestine Antibodies  >20 publications with AGR2 and Intestine
 Liver Antibodies  >8 publications with AGR2 and Liver
 Larynx Antibodies  >8 publications with AGR2 and Larynx
 Pancreas Antibodies  >8 publications with AGR2 and Pancreas
 Stomach Antibodies  >8 publications with AGR2 and Stomach
 Bladder Antibodies  >6 publications with AGR2 and Bladder
 Ovary Antibodies  >3 publications with AGR2 and Ovary
 Mammary Gland Antibodies  >3 publications with AGR2 and Mammary Gland
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