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TLR3 Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS539535

MBS539535 is an active protein targeting TLR3. Also known as TLR3 protein. Host: Human. Purified recombinant Human TLR3 protein More details

$685 / 0.025 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
TLR3, Active Protein
Full Product Name
TLR3 protein
Product Gene Name
TLR3 active protein
Product Synonym Names
TLR3; CD283 antigen protein; TLR-3 protein; TLR-3; Toll-like receptor 3; TLR 3 protein; TLR 3
Sequence
Region of TLR3 protein correspond ing to amino acids STTKCTVSHE VADCSHLKLT QVPDDLPTNI TVLNLTHNQL RRLPAANFTR YSQLTSLDVG FNTISKLEPE LCQKLPMLKV LNLQHNELSQ LSDKTFAFCT NLTELHLMSN SIQKIKNNPF VKQKNLITLD LSHNGLSSTK LGTQVQLENL QELLLSNNKI QALKSEELDI FANSSLKKLE LSSNQIKEFS PGCFHAIGRL FGLFLNNVQL GPSLTEKLCL ELANTSIRNL SLSNSQLSTT SNTTFLGLKW TNLTMLDLSY NNLNVVGNDS FAWLPQLEYF FLEYNNIQHL FSHSLHGLFN VRYLNLKRSF TKQSISLASL PKIDDFSFQW LKCLEHLNME DNDIPGIKSN MFTGLINLKY LSLSNSFTSL RTLTNETFVS LAHSPLHILN LTKNKISKIE SDAFSWLGHL EVLDLGLNEI GQELTGQEWR GLENIFEIYL SYNKYLQLTR NSFALVPSLQ RLMLRRVALK NVDSSPSPFQ PLRNLTILDL SNNNIANIND DMLEGLEKLE ILDLQHNNLA RLWKHANPGG PIYFLKGLSH LHILNLESNG FDEIPVEVFK DLFELKIIDL GLNNLNTLPA SVFNNQVSLK SLNLQKNLIT SVEKKVFGPA FRNLTELDMR FNPFDCTCES IAWFVNWINE THTNIPELSS HYLCNTPPHY HGFPVRLFDT SSCKDSAPFE L.
Host
Human
Form/Format
Lyophilized from 20mM Sodium Phosphate, pH 7.5. Centrifuge prior to opening. Reconstitute in water to 0.1-1.0mg/ml. Do not vortex.
Purity/Purification
>95% by SDS-PAGE gel and HPLC analysis
Concentration
25ug, lyophilized (lot specific)
Preparation and Storage
Ships ambient or refrigerated. Upon receipt store at 4 degree C short term, -20 degree C long term. Avoid repeat freeze-thaws.
Molecular Weight
77 kDa
3D Structure
ModBase 3D Structure for Q7TNI8
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Grade
Recombinant Human
Bioactivity
Determined by its ability to inhibit IL-8 secretion induced by Poly I:C in the TLR3 receptor-expressing HEK293 cells (HEK293 TLR3r). The ED50for this effect is approximately 30 ug/ml in the presence of 100 ug/ml of Poly I:C.
Source
HEK293 cells
Contaminants
Endotoxin level is <0.1ng/ug of protein
Biohazard
Use standard laboratory precautions when handling this material

Product Categories/Family for TLR3 active protein

Cytokines & Growth Factors
Applications Tested/Suitable for TLR3 active protein
User optimized

Other Notes

Small volumes of TLR3 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TLR3. It may not necessarily be applicable to this product.

NCBI GI #
38454316
NCBI GeneID
364594
NCBI Accession #
NP_942086.1
UniProt Primary Accession #
Q7TNI8
GenBank Nucleotide #
NM_198791.1
NCBI Official Full Name
toll-like receptor 3
NCBI Official Synonym Full Names
toll-like receptor 3
NCBI Official Symbol
Tlr3
UniProt Protein Name
Toll-like receptor 3
UniProt Synonym Protein Names
Toll-like receptor 3
Protein Family
Toll-like receptor
UniProt Gene Name
Tlr3
UniProt Entry Name
Q7TNI8_RAT
NCBI Protein Information
toll-like receptor 3

NCBI Summary for TLR3

human homolog induces activation of NF-kappaB; mouse homolog plays a role in the production of inflammatory cytokines [RGD, Feb 2006]

UniProt Comments for TLR3

TLR3: a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. Most abundantly expressed in placenta and pancreas. Restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection. Acts via MyD88 and TRAF6, leading to the activation of NF-kappaB and the production of type I interferon.

Protein type: Receptor, cytokine; Membrane protein, integral

Cellular Component: cell surface; lysosomal membrane; cytoplasm; integral to membrane; intracellular

Molecular Function: identical protein binding; transmembrane receptor activity; double-stranded RNA binding; receptor activity

Biological Process: positive regulation of apoptosis; positive regulation of interleukin-12 production; microglial cell activation; positive regulation of JNK cascade; defense response; positive regulation of NF-kappaB import into nucleus; positive regulation of interferon-alpha biosynthetic process; toll-like receptor 3 signaling pathway; activation of NF-kappaB transcription factor; positive regulation of interleukin-8 production; response to exogenous dsRNA; positive regulation of interferon-beta production; positive regulation of interferon type I production; defense response to virus; positive regulation of I-kappaB kinase/NF-kappaB cascade; response to virus; MyD88-independent toll-like receptor signaling pathway; male gonad development; response to dsRNA; positive regulation of interleukin-6 production; positive regulation of tumor necrosis factor production; positive regulation of chemokine production; positive regulation of toll-like receptor signaling pathway; positive regulation of chemokine biosynthetic process; positive regulation of interferon-beta biosynthetic process; toll-like receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; positive regulation of protein amino acid phosphorylation; I-kappaB phosphorylation; positive regulation of inflammatory response; microglial cell activation during immune response; positive regulation of interferon-gamma biosynthetic process
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Research Articles on TLR3

1. IL-1beta is the key trigger of neuroinflammation and that IL-1ra prevents the neuroinflammation entering the chronic state

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with TLR3 active protein

 Reference Product  PubMed Publications
 Myd88 active protein  >379 publications with TLR3 and Myd88
 Irf3 active protein  >231 publications with TLR3 and Irf3
 Stat1 active protein  >71 publications with TLR3 and Stat1
 Traf6 active protein  >42 publications with TLR3 and Traf6
 Unc93b1 active protein  >40 publications with TLR3 and Unc93b1
 Irak4 active protein  >22 publications with TLR3 and Irak4
 Irak1 active protein  >12 publications with TLR3 and Irak1
 Dhx58 active protein  >6 publications with TLR3 and Dhx58
 Tab2 active protein  >4 publications with TLR3 and Tab2

Pathways associated with TLR3 active protein

 Products by Pathway  Pathway Diagram
 Hepatitis B Pathway antibodies  Hepatitis B Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Toll-Like Receptors Cascades Pathway antibodies  Toll-Like Receptors Cascades Pathway Diagram

Diseases associated with TLR3 active protein

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >637 publications with TLR3 and Inflammation
 Necrosis Antibodies  >386 publications with TLR3 and Necrosis
 Lung Diseases Antibodies  >130 publications with TLR3 and Lung Diseases
 Asthma Antibodies  >90 publications with TLR3 and Asthma
 Kidney Diseases Antibodies  >67 publications with TLR3 and Kidney Diseases
 Neoplasms, Experimental Antibodies  >48 publications with TLR3 and Neoplasms, Experimental
 Adenocarcinoma Antibodies  >40 publications with TLR3 and Adenocarcinoma
 Heart Diseases Antibodies  >39 publications with TLR3 and Heart Diseases
 Encephalitis, Herpes Simplex Antibodies  >37 publications with TLR3 and Encephalitis, Herpes Simplex
 Carcinoma, Hepatocellular Antibodies  >36 publications with TLR3 and Carcinoma, Hepatocellular

Organs/Tissues associated with TLR3 active protein

 Organ/Tissue Name  Pubmed Publications
 Dorsal Root Ganglion Antibodies  >7 publications with TLR3 and Dorsal Root Ganglion
 Ovary Antibodies  >6 publications with TLR3 and Ovary
 Inner Ear Antibodies  >1 publications with TLR3 and Inner Ear
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