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NCAM2 Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS421506

MBS421506 is an antibody targeting NCAM2. Also known as Goat anti-NCAM2/OCAM Antibody. Reactive in Tested: Human, Mouse Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow. Host: Goat. More details

$450 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
NCAM2/OCAM, Polyclonal Antibody
Full Product Name
Goat anti-NCAM2/OCAM Antibody
Product Gene Name
anti-NCAM2 antibody
Product Synonym Gene Name
OCAM
Product Synonym Names
NCAM2; neural cell adhesion molecule 2; HGNC: 7657; MGC51008; NCAM21; OCAM; NCAM2 antibody; neural cell adhesion molecule 2 antibody; HGNC: 7657 antibody; MGC51008 antibody; NCAM21 antibody; OCAM antibody; NCAM2 / OCAM
Immunogen Sequence
KVSNDIIQSK EDDSK
Clonality
Polyclonal
Host
Goat
Species Reactivity
Tested: Human, Mouse
Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Preparation and Storage
Aliquot and store at -20°C. Minimize freezing and thawing.
Antibody/Peptide Pairs
NCAM2 / OCAM peptide (MBS425485) is used for blocking the activity of NCAM2/OCAM antibody (MBS421506)
OMIM
602040
Immunogen
Peptide with sequence C-KVSNDIIQSKEDDSK, from the C Terminus of the protein sequence according to NP_004531.2.
Epitope
C Terminus
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Applications Tested/Suitable for anti-NCAM2 antibody
Peptide ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-NCAM2 antibody
Peptide ELISA: Antibody detection limit dilution 1: 4000.


Western Blot: Preliminary experiments gave an approx 150 and 28kDa bands in Human and Mouse Brain lysates after 0.1ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 93. 0kDa according to NP_004531.2. Both observed bands were successfully blocked by incubation with the immunizing peptide.


Immunohistochemistry: Frozen section of Olfactory bulb from transcardially PFA-perfused Mouse shows strong staining of axon bundles (right side middle, figure 1) and moderate peripheral staining outside the glomeruli (top, figure 1). NCAM2 (red) is stained complementary to VGLUT2 (blue) and NQO1 (green) in figure 2. Recommended concentration:0.5 ug/mL. Paraffin embedded Human Brain (Cortex). Recommended concentration is: 3.75ug/ml.

Immunofluorescence (IF) of anti-NCAM2 antibody

(0.5ug/ml) 24h-staining of PFA-perfused cryosection of Mouse Olfactory bub. Antigen retrieval with methanol (-20C, 10min) followed by 1% SDS(10min), IF-staning. Data obtained from anonymous customer.
Goat Anti-NCAM2 Polyclonal Antibody – Cat# MBS421506

Immunofluorescence (IF) of anti-NCAM2 antibody

(0.5ug/ml) 48h-staining of PFA-perfused cryosection of Mouse Olfactory bulb. Antigen retrieval with citrate buffer pH 6 at 95C for 10min, IF-staning for NCAM2 (red), VGLUT2 (blue) and NQO1 (green), data obtained from anonymus customer.
Goat Anti-NCAM2 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS421506

Testing Data(TD) of anti-NCAM2 antibody

(3.75 ug/mL) staining of paraffin embedded Human Cortex. Steamed antigen retrieval with citrate buffer pH, AP-staining.
Goat Anti-NCAM2 Polyclonal Antibody, Testing Data(TD) – Cat# MBS421506

Other Notes

Small volumes of anti-NCAM2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for NCAM2. It may not necessarily be applicable to this product.

NCBI GI #
33519481
NCBI GeneID
4685
NCBI Accession #
NP_004531.2
UniProt Secondary Accession #
Q7Z7F2; A8MQ06; B7Z841
UniProt Related Accession #
O15394
GenBank Nucleotide #
NM_004540.3
NCBI Official Full Name
neural cell adhesion molecule 2
NCBI Official Synonym Full Names
neural cell adhesion molecule 2
NCBI Official Symbol
NCAM2
NCBI Official Synonym Symbols
NCAM21
UniProt Protein Name
Neural cell adhesion molecule 2
Protein Family
Neural cell adhesion molecule
UniProt Gene Name
NCAM2
UniProt Synonym Gene Names
NCAM21; N-CAM-2; NCAM-2
UniProt Entry Name
NCAM2_HUMAN
NCBI Protein Information
neural cell adhesion molecule 2

NCBI Summary for NCAM2

The protein encoded by this gene belongs to the immunoglobulin superfamily. It is a type I membrane protein and may function in selective fasciculation and zone-to-zone projection of the primary olfactory axons. [provided by RefSeq, Jul 2008]

UniProt Comments for NCAM2

NCAM2: May play important roles in selective fasciculation and zone-to-zone projection of the primary olfactory axons.

Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Cell adhesion

Chromosomal Location of Human Ortholog: 21q21.1

Cellular Component: axon; integral to membrane; plasma membrane

Biological Process: neuron adhesion
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Research Articles on NCAM2

1. A complete structural model of the entire ectodomain of human NCAM2 has been assembled from crystal structures of six recombinant proteins corresponding to different regions of the ectodomain.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-NCAM2 antibody

 Products by Pathway  Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Prion Diseases Pathway antibodies  Prion Diseases Pathway Diagram
 Prion Diseases Pathway antibodies  Prion Diseases Pathway Diagram

Diseases associated with anti-NCAM2 antibody

 Disease Name  Pubmed Publications
 Abnormalities, Multiple Antibodies  >5 publications with NCAM2 and Abnormalities, Multiple
 Brain Diseases Antibodies  >3 publications with NCAM2 and Brain Diseases
 Prostatic Diseases Antibodies  >3 publications with NCAM2 and Prostatic Diseases
 Lung Diseases Antibodies  >2 publications with NCAM2 and Lung Diseases
 Breast Neoplasms Antibodies  >2 publications with NCAM2 and Breast Neoplasms
 Disease Models, Animal Antibodies  >1 publications with NCAM2 and Disease Models, Animal
 Inflammation Antibodies  >1 publications with NCAM2 and Inflammation
 Hyperplasia Antibodies  >1 publications with NCAM2 and Hyperplasia
 Necrosis Antibodies  >1 publications with NCAM2 and Necrosis

Organs/Tissues associated with anti-NCAM2 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >31 publications with NCAM2 and Brain
 Nerve Antibodies  >12 publications with NCAM2 and Nerve
 Embryonic Tissue Antibodies  >4 publications with NCAM2 and Embryonic Tissue
 Prostate Antibodies  >3 publications with NCAM2 and Prostate
 Blood Antibodies  >2 publications with NCAM2 and Blood
 Lung Antibodies  >2 publications with NCAM2 and Lung
 Testis Antibodies  >2 publications with NCAM2 and Testis
 Vascular Antibodies  >1 publications with NCAM2 and Vascular
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