ENOX2 Antibody – Goat Polyclonal

This gene is a tumor-specific member of the ECTO-NOX family of genes that encode cell surface NADH oxidases. The encoded protein has two enzymatic activities: catalysis of hydroquinone or NADH oxidation, and protein disulfide interchange. The protein also displays prion-like properties. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

ENOX2: May be involved in cell growth. Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide- thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 22 minutes and play a role in control of the ultradian cellular biological clock. Belongs to the ENOX family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytoskeletal; Cell surface; EC 1.-.-.-; Oxidoreductase

Chromosomal Location of Human Ortholog: Xq25

Cellular Component: cytosol; external side of plasma membrane; extracellular space

Molecular Function: nucleic acid binding; nucleotide binding; protein binding; protein disulfide oxidoreductase activity

Biological Process: cell growth; regulation of growth; ultradian rhythm