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KCNB1 Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS421559

MBS421559 is an antibody targeting KCNB1. Also known as Goat anti-KCNB1/DRK1 Antibody. Reactive in Expected from sequence similarity: Human, Mouse, Dog, Cow, Pig. Host: Goat. More details

$305 / 0.1 mg +1 FREE 8GB USB
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
KCNB1/DRK1, Polyclonal Antibody
Full Product Name
Goat anti-KCNB1/DRK1 Antibody
Product Gene Name
anti-KCNB1 antibody
Product Synonym Gene Name
DRK1
Product Synonym Names
KCNB1; potassium voltage-gated channel, Shab-related subfamily, member 1; DRK1; KV2.1; h-DRK1; delayed rectifier potassium channel Kv2.1; h-DRK1 K channel; potassium channel protein DRK1; potassium voltage-gated channel subfamily B member 1; voltage-gated; KCNB1 antibody; potassium voltage-gated channel; Shab-related subfamily; member 1 antibody; DRK1 antibody; KV2.1 antibody; h-DRK1 antibody; delayed rectifier potassium channel Kv2.1 antibody; h-DRK1 K channel antibody; potassium channel protein DRK1 antibody; potassium voltage-gated channel subfamily B member 1 antibody; voltage-gated potassium channel antibody; KCNB1 / DRK1
Immunogen Sequence
HQYIDADTDD EGQ
Clonality
Polyclonal
Host
Goat
Species Reactivity
Expected from sequence similarity: Human, Mouse, Dog, Cow, Pig
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration
100ug specific antibody in 200ul (lot specific)
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
Antibody/Peptide Pairs
KCNB1 / DRK1 peptide (MBS426792) is used for blocking the activity of KCNB1/DRK1 antibody (MBS421559)
Molecular Weight
95,878 Da
OMIM
600397
Immunogen
Peptide with sequence C-HQYIDADTDDEGQ, from the internal region of the protein sequence according to NP_004966.1.
Epitope
Internal region
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Applications Tested/Suitable for anti-KCNB1 antibody
Peptide ELISA (EIA)
Application Notes for anti-KCNB1 antibody
Peptide ELISA: Antibody detection limit dilution 1: 4000.
Western Blot: Preliminary experiments gave a 100kDa band and additional stronger bands at approx 50kDa and 38kDa in Human Brain (Cerebellum) and Heart lysates after 0.5ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the extra bands we observe given the calculated size of 95.9kDa according to NP_004966.1. Both detected extra bands were successfully blocked by incubation with the immunizing peptide (and BLAST results with the immunizing peptide sequence did not identify any other proteins to explain the additional bands).

Other Notes

Small volumes of anti-KCNB1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for KCNB1. It may not necessarily be applicable to this product.

NCBI GI #
4826784
NCBI GeneID
3745
NCBI Accession #
NP_004966.1
UniProt Secondary Accession #
Q14193
UniProt Related Accession #
Q14721
GenBank Nucleotide #
NM_004975.3
NCBI Official Full Name
potassium voltage-gated channel subfamily B member 1
NCBI Official Synonym Full Names
potassium voltage-gated channel subfamily B member 1
NCBI Official Symbol
KCNB1
NCBI Official Synonym Symbols
DRK1; Kv2.1
UniProt Protein Name
Potassium voltage-gated channel subfamily B member 1
UniProt Synonym Protein Names
Delayed rectifier potassium channel 1
Protein Family
Potassium voltage-gated channel subfamily
UniProt Gene Name
KCNB1
UniProt Synonym Gene Names
h-DRK1
UniProt Entry Name
KCNB1_HUMAN
NCBI Protein Information
potassium voltage-gated channel subfamily B member 1

NCBI Summary for KCNB1

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel and its activity is modulated by some other family members. [provided by RefSeq, Jul 2008]
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UniProt Comments for KCNB1

Kv2.1: a potassium voltage-gated channel protein of subfamily B. Mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close in response to the voltage difference across the membrane, letting K ions pass in accordance with their electrochemical gradient.

Protein type: Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Channel, cation; Channel, potassium

Chromosomal Location of Human Ortholog: 20q13.2

Cellular Component: axon; cell junction; dendrite; intracellular; lateral plasma membrane; perikaryon; plasma membrane; postsynaptic membrane; sarcolemma; voltage-gated potassium channel complex

Molecular Function: delayed rectifier potassium channel activity; protein binding; protein heterodimerization activity; small conjugating protein binding

Biological Process: cellular response to nutrient levels; glucose homeostasis; glutamate signaling pathway; negative regulation of insulin secretion; positive regulation of calcium ion-dependent exocytosis; positive regulation of catecholamine secretion; protein homooligomerization; regulation of action potential; regulation of insulin secretion; vesicle docking during exocytosis

Disease: Epileptic Encephalopathy, Early Infantile, 26
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Research Articles on KCNB1

1. Glutamate exposure results in a loss of Kv2.1 clusters in neurons.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-KCNB1 antibody

 Reference Product  PubMed Publications
 KCNH2 antibody  >6 publications with KCNB1 and KCNH2
 KCNG3 antibody  >6 publications with KCNB1 and KCNG3
 KCNV2 antibody  >4 publications with KCNB1 and KCNV2
 KCNV1 antibody  >3 publications with KCNB1 and KCNV1
 KCNS3 antibody  >2 publications with KCNB1 and KCNS3
 KCNG1 antibody  >1 publications with KCNB1 and KCNG1
 KCNH6 antibody  >1 publications with KCNB1 and KCNH6
 KCNH1 antibody  >1 publications with KCNB1 and KCNH1

Pathways associated with anti-KCNB1 antibody

 Products by Pathway  Pathway Diagram
 Calcium Regulation In The Cardiac Cell Pathway antibodies  Calcium Regulation In The Cardiac Cell Pathway Diagram
 Glucagon-like Peptide-1 (GLP1) Regulates Insulin Secretion Pathway antibodies  Glucagon-like Peptide-1 (GLP1) Regulates Insulin Secretion Pathway Diagram
 Integration Of Energy Metabolism Pathway antibodies  Integration Of Energy Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
 Potassium Channels Pathway antibodies  Potassium Channels Pathway Diagram
 Regulation Of Insulin Secretion Pathway antibodies  Regulation Of Insulin Secretion Pathway Diagram
 Voltage Gated Potassium Channels Pathway antibodies  Voltage Gated Potassium Channels Pathway Diagram

Diseases associated with anti-KCNB1 antibody

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >18 publications with KCNB1 and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >15 publications with KCNB1 and Disease Models, Animal
 Heart Diseases Antibodies  >14 publications with KCNB1 and Heart Diseases
 Nervous System Diseases Antibodies  >14 publications with KCNB1 and Nervous System Diseases
 Brain Diseases Antibodies  >11 publications with KCNB1 and Brain Diseases
 Hypertension Antibodies  >9 publications with KCNB1 and Hypertension
 Hypertrophy Antibodies  >6 publications with KCNB1 and Hypertrophy
 Lung Diseases Antibodies  >5 publications with KCNB1 and Lung Diseases
 Myocardial Infarction Antibodies  >2 publications with KCNB1 and Myocardial Infarction
 Cardiomegaly Antibodies  >2 publications with KCNB1 and Cardiomegaly

Organs/Tissues associated with anti-KCNB1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >67 publications with KCNB1 and Brain
 Muscle Antibodies  >55 publications with KCNB1 and Muscle
 Heart Antibodies  >33 publications with KCNB1 and Heart
 Vascular Antibodies  >23 publications with KCNB1 and Vascular
 Kidney Antibodies  >15 publications with KCNB1 and Kidney
 Eye Antibodies  >5 publications with KCNB1 and Eye
 Ovary Antibodies  >1 publications with KCNB1 and Ovary
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