WNT15/WNT9B (WNT9B) Antibody – Goat Polyclonal

The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. Study of its expression in the teratocarcinoma cell line NT2 suggests that it may be implicated in the early process of neuronal differentiation of NT2 cells induced by retinoic acid. This gene is clustered with WNT3, another family member, in the chromosome 17q21 region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

WNT9B: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Belongs to the Wnt family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 17q21

Cellular Component: extracellular region; extracellular space; proteinaceous extracellular matrix

Molecular Function: frizzled binding

Biological Process: cell fate commitment; cell-cell signaling; cellular response to starvation; embryonic cranial skeleton morphogenesis; in utero embryonic development; male genitalia development; multicellular organismal development; neuron differentiation; palate development; positive regulation of catalytic activity; regulation of asymmetric cell division; regulation of protein amino acid phosphorylation; regulation of tube size; response to retinoic acid; ureteric bud branching; Wnt receptor signaling pathway; Wnt receptor signaling pathway through beta-catenin; Wnt receptor signaling pathway, planar cell polarity pathway