Goat Anti-FKBP8 Polyclonal Antibody – Cat# MBS421858

FKBP8 Antibody – Goat Polyclonal

Name: FKBP8 Antibody; Polyclonal; Goat; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS421858
Price: 305 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS421858

MBS421858 is an antibody targeting FKBP8. Also known as Goat anti-FKBP8/FKBP38 Antibody. Reactive in Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow. Host: Goat. More details

$305 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

FKBP8/FKBP38, Polyclonal Antibody

Full Product Name

Goat anti-FKBP8/FKBP38 Antibody

Product Gene Name

anti-FKBP8 antibody

Product Synonym Gene Name

FKBP38

Product Synonym Names

FKBP8; FK506 binding protein 8, 38kDa; FKBP38; FKBPr38; FK506 binding protein 8 (38kD); FK506-binding protein 8; FK506-binding protein 8 (38kD); FKBP8 antibody; FK506 binding protein 8; 38kDa antibody; FKBP38 antibody; FKBPr38 antibody; FK506 binding protein 8 (38kD) antibody; FK506-binding protein 8 antibody; FK506-binding protein 8 (38kD) antibody; FKBP8 / FKBP38

Immunogen Sequence

KLEPSNKTIH AELSK

Clonality

Polyclonal

Host

Goat

Species Reactivity

Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow

Form/Format

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

Purity/Purification

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.

Concentration

100ug specific antibody in 200ul (lot specific)

Preparation and Storage

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Antibody/Peptide Pairs

FKBP8 / FKBP38 peptide (MBS426888) is used for blocking the activity of FKBP8/FKBP38 antibody (MBS421858)

Molecular Weight

27,545 Da

OMIM

604840

Immunogen

Peptide with sequence C-KLEPSNKTIHAELSK, from the internal region of the protein sequence according to NP_036313.3.

Epitope

Internal region

ISO Certification

Manufactured in an ISO 9001:2008 Certified Laboratory.

Applications Tested/Suitable for anti-FKBP8 antibody

Peptide ELISA (EIA)

Application Notes for anti-FKBP8 antibody

Peptide ELISA: Antibody detection limit dilution 1: 32000.
Western Blot: Preliminary experiments gave an approx 28kDa band in Human Brain (Frontal Cortex) and Rat Brain lysates after 1ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 44.6kDa according to NP_036313.3. The 28kDa band was successfully blocked by incubation with the immunizing peptide.

Other Notes

Small volumes of anti-FKBP8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for FKBP8. It may not necessarily be applicable to this product.

NCBI GI #

52630440

NCBI GeneID

23770

NCBI Accession #

NP_036313.3

UniProt Secondary Accession #

Q53GU3; Q7Z349; Q86YK6; C8C9T5

UniProt Related Accession #

Q14318

GenBank Nucleotide #

NM_012181.4

NCBI Official Full Name

peptidyl-prolyl cis-trans isomerase FKBP8 isoform 1

NCBI Official Synonym Full Names

FK506 binding protein 8

NCBI Official Symbol

FKBP8

NCBI Official Synonym Symbols

FKBP38; FKBPr38

UniProt Protein Name

Peptidyl-prolyl cis-trans isomerase FKBP8

UniProt Synonym Protein Names

38 kDa FK506-binding protein; 38 kDa FKBP; FKBP-38; hFKBP38; FK506-binding protein 8; FKBP-8; FKBPR38; Rotamase

Protein Family

Peptidyl-prolyl cis-trans isomerase

UniProt Gene Name

FKBP8

UniProt Synonym Gene Names

FKBP38; PPIase FKBP8; 38 kDa FKBP; FKBP-38; hFKBP38; FKBP-8

UniProt Entry Name

FKBP8_HUMAN

NCBI Protein Information

peptidyl-prolyl cis-trans isomerase FKBP8

NCBI Summary for FKBP8

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. Unlike the other members of the family, this encoded protein does not seem to have PPIase/rotamase activity. It may have a role in neurons associated with memory function. [provided by RefSeq, Jul 2008]

UniProt Comments for FKBP8

FKBP8: Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 5.2.1.8; Membrane protein, integral; Isomerase; Chaperone; Mitochondrial

Chromosomal Location of Human Ortholog: 19p12

Cellular Component: endoplasmic reticulum membrane; integral to endoplasmic reticulum membrane; membrane; mitochondrial membrane

Molecular Function: FK506 binding; identical protein binding; metal ion binding; peptidyl-prolyl cis-trans isomerase activity; protein binding

Biological Process: apoptosis; camera-type eye development; cell fate specification; dorsoventral neural tube patterning; multicellular organism growth; negative regulation of apoptosis; positive regulation of BMP signaling pathway; protein peptidyl-prolyl isomerization; smoothened signaling pathway; viral reproduction

Research Articles on FKBP8

1. The information presented here provides important clues for understanding the catalytic activity of FKBP38, its regulation by the unique N-terminal extension, and the potential calcium- and calmodulin-mediated activation of FKBP38.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-FKBP8 antibody

Products by Pathway	Pathway Diagram
Role Of Calcineurin-dependent NFAT Signaling In Lymphocytes Pathway antibodies	Role Of Calcineurin-dependent NFAT Signaling In Lymphocytes Pathway Diagram
Senescence And Autophagy Pathway antibodies	Senescence And Autophagy Pathway Diagram

Diseases associated with anti-FKBP8 antibody

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>10 publications with FKBP8 and Nervous System Diseases
Congenital Abnormalities Antibodies	>6 publications with FKBP8 and Congenital Abnormalities
Liver Diseases Antibodies	>5 publications with FKBP8 and Liver Diseases
Brain Diseases Antibodies	>3 publications with FKBP8 and Brain Diseases
Neoplasm Metastasis Antibodies	>2 publications with FKBP8 and Neoplasm Metastasis
Fibrosis Antibodies	>2 publications with FKBP8 and Fibrosis
Fever Antibodies	>1 publications with FKBP8 and Fever
Liver Neoplasms Antibodies	>1 publications with FKBP8 and Liver Neoplasms
Neoplasms, Experimental Antibodies	>1 publications with FKBP8 and Neoplasms, Experimental
Kidney Diseases Antibodies	>1 publications with FKBP8 and Kidney Diseases

Organs/Tissues associated with anti-FKBP8 antibody

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>6 publications with FKBP8 and Liver
Brain Antibodies	>6 publications with FKBP8 and Brain
Nerve Antibodies	>4 publications with FKBP8 and Nerve
Kidney Antibodies	>3 publications with FKBP8 and Kidney
Bone Antibodies	>2 publications with FKBP8 and Bone
Embryonic Tissue Antibodies	>2 publications with FKBP8 and Embryonic Tissue
Ganglia Antibodies	>2 publications with FKBP8 and Ganglia
Eye Antibodies	>2 publications with FKBP8 and Eye
Ovary Antibodies	>1 publications with FKBP8 and Ovary
Blood Antibodies	>1 publications with FKBP8 and Blood