Goat Anti-IKZF4 Polyclonal Antibody – Cat# MBS421924

IKZF4 Antibody – Goat Polyclonal

Name: IKZF4 Antibody; Polyclonal; Goat; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS421924
Price: 450 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS421924

MBS421924 is an antibody targeting IKZF4. Also known as Goat anti-IKZF4 Antibody. Reactive in Expected from sequence similarity: Human, Mouse, Dog, Cow. Host: Goat. More details

$450 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

IKZF4, Polyclonal Antibody

Full Product Name

Goat anti-IKZF4 Antibody

Product Gene Name

anti-IKZF4 antibody

Product Synonym Names

IKZF4; IKAROS family zinc finger 4 (Eos); EOS; KIAA1782; ZNFN1A4; zinc finger protein, subfamily 1A, 4; zinc finger protein, subfamily 1A, 4 (Eos); zinc finger transcription factor Eos; EOS antibody; IKAROS family zinc finger 4 (Eos) antibody; KIAA1782 antibody; zinc finger protein; subfamily 1A; 4 antibody; zinc finger protein; subfamily 1A; 4 (Eos) antibody; zinc finger transcription factor Eos antibody; ZNFN1A4 antibody; IKZF4 antibody

Immunogen Sequence

RPTFIDRLAN SLTKR

Clonality

Polyclonal

Host

Goat

Species Reactivity

Expected from sequence similarity: Human, Mouse, Dog, Cow

Form/Format

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

Purity/Purification

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.

Concentration

100ug specific antibody in 200ul (lot specific)

Preparation and Storage

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Antibody/Peptide Pairs

IKZF4 peptide (MBS425879) is used for blocking the activity of IKZF4 antibody (MBS421924)

Molecular Weight

59,671 Da

OMIM

606239

Immunogen

Peptide with sequence C-RPTFIDRLANSLTKR, from the internal region of the protein sequence according to NP_071910.3.

Epitope

Internal region

ISO Certification

Manufactured in an ISO 9001:2008 Certified Laboratory.

Applications Tested/Suitable for anti-IKZF4 antibody

Peptide ELISA (EIA)

Application Notes for anti-IKZF4 antibody

Peptide ELISA: Antibody detection limit dilution 1: 2000.
Western Blot: Preliminary experiments in HG2, K562, Human Breast Cancer, Human Thymus and Human Lymphnode lysates gave no specific signal but low background (at antibody concentration up to 2ug/ml).

Other Notes

Small volumes of anti-IKZF4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for IKZF4. It may not necessarily be applicable to this product.

NCBI GI #

122891864

NCBI GeneID

64375

NCBI Accession #

NP_071910.3

UniProt Secondary Accession #

Q96JP3

UniProt Related Accession #

Q9H2S9

GenBank Nucleotide #

NM_022465.3

NCBI Official Full Name

zinc finger protein Eos

NCBI Official Synonym Full Names

IKAROS family zinc finger 4

NCBI Official Symbol

IKZF4

NCBI Official Synonym Symbols

EOS; ZNFN1A4

UniProt Protein Name

Zinc finger protein Eos

UniProt Synonym Protein Names

Ikaros family zinc finger protein 4

Protein Family

Zinc finger protein

UniProt Gene Name

IKZF4

UniProt Synonym Gene Names

KIAA1782; ZNFN1A4

UniProt Entry Name

IKZF4_HUMAN

NCBI Protein Information

zinc finger protein Eos

NCBI Summary for IKZF4

Members of the Ikaros (ZNFN1A1; MIM 603023) family of transcription factors, which includes Eos, are expressed in lymphocytes and are implicated in the control of lymphoid development.[supplied by OMIM, Jul 2002]

UniProt Comments for IKZF4

IKZF4: DNA-binding protein that binds to the 5'GGGAATRCC-3' Ikaros-binding sequence. Transcriptional repressor. Interacts with SPI1 and MITF to repress transcription of the CTSK and ACP5 promoters via recruitment of corepressors SIN3A and CTBP2. May be involved in the development of central and peripheral nervous systems. Belongs to the Ikaros C2H2-type zinc-finger protein family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor; DNA-binding; C2H2-type zinc finger protein

Chromosomal Location of Human Ortholog: 12q13

Cellular Component: centrosome; nucleoplasm; nucleus

Molecular Function: bHLH transcription factor binding; metal ion binding; protein heterodimerization activity; protein homodimerization activity; sequence-specific DNA binding; transcription factor activity

Biological Process: negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent

Research Articles on IKZF4

1. IKZF4 polymorphism (rs1701704) was strongly associated with insulin autobody positivity at the time of type 1 diabetes diagnosis

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-IKZF4 antibody

Disease Name	Pubmed Publications
Inflammation Antibodies	>3 publications with IKZF4 and Inflammation
Alopecia Areata Antibodies	>2 publications with IKZF4 and Alopecia Areata
Disease Models, Animal Antibodies	>1 publications with IKZF4 and Disease Models, Animal
Vitiligo Antibodies	>1 publications with IKZF4 and Vitiligo

Organs/Tissues associated with anti-IKZF4 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>8 publications with IKZF4 and Blood
Thymus Antibodies	>2 publications with IKZF4 and Thymus
Skin Antibodies	>2 publications with IKZF4 and Skin
Pancreas Antibodies	>2 publications with IKZF4 and Pancreas
Eye Antibodies	>2 publications with IKZF4 and Eye