INO80 Antibody – Goat Polyclonal

This gene encodes a subunit of the chromatin remodeling complex, which is classified into subfamilies depending on sequence features apart from the conserved ATPase domain. This protein is the catalytic ATPase subunit of the INO80 chromatin remodeling complex, which is characterized by a DNA-binding domain. This protein is proposed to bind DNA and be recruited by the YY1 transcription factor to activate certain genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

INOC1: DNA helicase and probable main scaffold component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; according to PubMed:20687897 the contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation. Recruited by YY1 to YY1-activated genes, where it acts as an essential coactivator. Binds DNA. In vitro, has double stranded DNA-dependent ATPase activity. Involved in UV-damage excision repair, DNA replication and chromosome segregation during normal cell division cycle. Belongs to the SNF2/RAD54 helicase family.

Protein type: EC 3.6.4.12; Helicase; DNA-binding

Chromosomal Location of Human Ortholog: 15q15.1

Cellular Component: microtubule; nucleus

Molecular Function: actin binding; alpha-tubulin binding; ATP binding; ATPase activity; DNA binding; DNA helicase activity; protein binding

Biological Process: cell division; chromatin remodeling; DNA duplex unwinding; double-strand break repair; double-strand break repair via homologous recombination; mitotic sister chromatid segregation; positive regulation of cell growth; positive regulation of transcription from RNA polymerase II promoter; spindle assembly; transcription, DNA-dependent