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MPV17 Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS422495

MBS422495 is an antibody targeting MPV17. Also known as Goat anti-MPV17 Antibody. Reactive in Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow. Host: Goat. More details

$450 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
MPV17, Polyclonal Antibody
Full Product Name
Goat anti-MPV17 Antibody
Product Gene Name
anti-MPV17 antibody
Product Synonym Names
MPV17; MpV17 mitochondrial inner membrane protein; SYM1; Mpv17 protein; Mpv17, human homolog of glomerulosclerosis and nephrotic syndrome; OTTHUMP00000122591; MpV17 mitochondrial inner membrane protein antibody; Mpv17 protein antibody; Mpv17; human homolog of glomerulosclerosis and nephrotic syndrome antibody; OTTHUMP00000122591 antibody; SYM1 antibody; MPV17 antibody
Immunogen Sequence
QRALAAHPWK VQ
Clonality
Polyclonal
Host
Goat
Species Reactivity
Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration
100ug specific antibody in 200ul (lot specific)
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
Antibody/Peptide Pairs
MPV17 peptide (MBS427742) is used for blocking the activity of MPV17 antibody (MBS422495)
Molecular Weight
19,733 Da
OMIM
137960
Immunogen
Peptide with sequence C-QRALAAHPWKVQ, from the internal region of the protein sequence according to NP_002428.1.
Epitope
Internal region
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Applications Tested/Suitable for anti-MPV17 antibody
Peptide ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-MPV17 antibody
Peptide ELISA: Antibody detection limit dilution 1: 32000.
Immunohistochemistry: In paraffin embedded Human Liver shows heavy textured cystoplasm staining in hepatocytes, consistent with mitochondia. Recommended concentration, 5-10ug/ml.

Western Blot (WB) of anti-MPV17 antibody

(2ug/ml) staining of Human Frontal Cortex lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Goat Anti-MPV17 Polyclonal Antibody – Cat# MBS422495

Immunohistochemistry (IHC) of anti-MPV17 antibody

(5ug/ml) staining of paraffin embedded Human Liver. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
Goat Anti-MPV17 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS422495

Other Notes

Small volumes of anti-MPV17 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for MPV17. It may not necessarily be applicable to this product.

NCBI GI #
4505241
NCBI GeneID
4358
NCBI Accession #
NP_002428.1
UniProt Secondary Accession #
Q53SY2; Q96B08; D6W555
UniProt Related Accession #
P39210; AAB25210
GenBank Nucleotide #
NM_002437.4
NCBI Official Full Name
protein Mpv17
NCBI Official Synonym Full Names
MPV17, mitochondrial inner membrane protein
NCBI Official Symbol
MPV17
NCBI Official Synonym Symbols
SYM1; MTDPS6
UniProt Protein Name
Protein Mpv17
Protein Family
Protein
UniProt Gene Name
MPV17
UniProt Entry Name
MPV17_HUMAN
NCBI Protein Information
protein Mpv17

NCBI Summary for MPV17

This gene encodes a mitochondrial inner membrane protein that is implicated in the metabolism of reactive oxygen species. Mutations in this gene have been associated with the hepatocerebral form of mitochondrial DNA depletion syndrome (MDDS). [provided by RefSeq, Jul 2008]

UniProt Comments for MPV17

MPV17: Involved in mitochondria homeostasis. May be involved in the metabolism of reactive oxygen species and control of oxidative phosphorylation and mitochondrial DNA (mtDNA) maintenance. Defects in MPV17 are the cause of mitochondrial DNA depletion syndrome type 6 (MTDPS6). A disease characterized by infantile onset of progressive liver failure, often leading to death in the first year of life, peripheral neuropathy, corneal scarring, acral ulceration and osteomyelitis leading to autoamputation, cerebral leukoencephalopathy, failure to thrive, and recurrent metabolic acidosis with intercurrent infections. Belongs to the peroxisomal membrane protein PXMP2/4 family.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial

Chromosomal Location of Human Ortholog: 2p23.3

Cellular Component: integral to membrane; mitochondrial inner membrane; mitochondrion; peroxisome

Biological Process: glomerular basement membrane development; homeostatic process; inner ear development; mitochondrial genome maintenance

Disease: Mitochondrial Dna Depletion Syndrome 6 (hepatocerebral Type)
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Research Articles on MPV17

1. MPV17 is a Deltapsim-modulating channel that apparently contributes to mitochondrial homeostasis under different conditions

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MPV17 antibody

 Reference Product  PubMed Publications
 DGUOK antibody  >25 publications with MPV17 and DGUOK
 POLG antibody  >24 publications with MPV17 and POLG
 SUCLA2 antibody  >14 publications with MPV17 and SUCLA2
 MTERF antibody  >1 publications with MPV17 and MTERF

Pathways associated with anti-MPV17 antibody

 Products by Pathway  Pathway Diagram
 Peroxisome Pathway antibodies  Peroxisome Pathway Diagram
 Peroxisome Pathway antibodies  Peroxisome Pathway Diagram

Diseases associated with anti-MPV17 antibody

 Disease Name  Pubmed Publications
 Mitochondrial Diseases Antibodies  >50 publications with MPV17 and Mitochondrial Diseases
 Liver Diseases Antibodies  >36 publications with MPV17 and Liver Diseases
 Nervous System Diseases Antibodies  >22 publications with MPV17 and Nervous System Diseases
 Kidney Diseases Antibodies  >21 publications with MPV17 and Kidney Diseases
 Nephritis Antibodies  >14 publications with MPV17 and Nephritis
 Glomerulosclerosis, Focal Segmental Antibodies  >10 publications with MPV17 and Glomerulosclerosis, Focal Segmental
 Liver Failure, Acute Antibodies  >5 publications with MPV17 and Liver Failure, Acute
 Proteinuria Antibodies  >4 publications with MPV17 and Proteinuria
 Immune System Diseases Antibodies  >2 publications with MPV17 and Immune System Diseases
 Diabetes Mellitus Antibodies  >2 publications with MPV17 and Diabetes Mellitus

Organs/Tissues associated with anti-MPV17 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >39 publications with MPV17 and Liver
 Kidney Antibodies  >24 publications with MPV17 and Kidney
 Muscle Antibodies  >19 publications with MPV17 and Muscle
 Brain Antibodies  >14 publications with MPV17 and Brain
 Ear Antibodies  >9 publications with MPV17 and Ear
 Blood Antibodies  >7 publications with MPV17 and Blood
 Skin Antibodies  >3 publications with MPV17 and Skin
 Heart Antibodies  >1 publications with MPV17 and Heart
 Spleen Antibodies  >1 publications with MPV17 and Spleen
 Embryonic Tissue Antibodies  >1 publications with MPV17 and Embryonic Tissue
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