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TSPYL2 Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS422757

MBS422757 is an antibody targeting TSPYL2. Also known as Goat anti-TSPYL2 (aa441-454) Antibody. Reactive in Tested: Human; Expected from sequence similarity: Human. Host: Goat. More details

$450 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
TSPYL2, Polyclonal Antibody
Full Product Name
Goat anti-TSPYL2 (aa441-454) Antibody
Product Gene Name
anti-TSPYL2 antibody
Product Synonym Names
Goat Anti-TSPYL2 (aa2-13) Antibody; TSPYL2; TSPY-like 2; CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79; SE204; TSPX; CASK-interacting nucleosome assembly protein; CTCL tumor antigen se20-4; CTCL-associated antigen se20-4; TSPY-like protein 2; cell division autoantigen 1; cutaneous T-cell lymph; CASK-interacting nucleosome assembly protein antibody; CDA1 antibody; cell division autoantigen 1 antibody; CINAP antibody; CTCL antibody; CTCL tumor antigen se20-4 antibody; CTCL-associated antigen se20-4 antibody; cutaneous T-cell lymphoma-associated antigen se20-4 antibody; cutaneous T-cell lymphoma-associated tumor antigen se20-4 antibody; DENTT antibody; differentially expressed nucleolar TGF-beta1 target antibody; differentially-expressed nucleolar TGF-beta1 target protein antibody; HRIHFB2216 antibody; NP79 antibody; nuclear protein of 79 kDa antibody; SE204 antibody; testis-specific protein Y encoded-like 2 antibody; testis-specific Y-encoded-like protein 2 antibody; TSPX antibody; TSPY-like 2 antibody; TSPY-like protein 2 antibody; TSPYL2 antibody; TSPYL2 (aa441-454)
Immunogen Sequence
SDIDETIHDI KISD
Clonality
Polyclonal
Host
Goat
Species Reactivity
Tested: Human; Expected from sequence similarity: Human
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration
100ug specific antibody in 200ul (lot specific)
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
Antibody/Peptide Pairs
TSPYL2 peptide (MBS427436) is used for blocking the activity of TSPYL2 antibody (MBS422757)
Molecular Weight
79,435 Da
OMIM
300564
Immunogen
Peptide with sequence C-SDIDETIHDIKISD, from the internal region of the protein sequence according to NP_071400.1.
Epitope
Internal region
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Applications Tested/Suitable for anti-TSPYL2 antibody
Peptide ELISA (EIA), Western Blot (WB)
Application Notes for anti-TSPYL2 antibody
Peptide ELISA: Antibody detection limit dilution 1: 64000.
Western Blot: Approx 75kDa band observed in lysates of cell lines Jurkat and MOLT4 (calculated MW of 79.4kDa according to NP_071400.1). Recommended concentration: 0.3-1ug/ml.

Western Blot (WB) of anti-TSPYL2 antibody

(0.3ug/ml) staining of Jurkat lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Goat Anti-TSPYL2 Polyclonal Antibody – Cat# MBS422757

Other Notes

Small volumes of anti-TSPYL2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TSPYL2. It may not necessarily be applicable to this product.

NCBI GI #
11545835
NCBI GeneID
64061
NCBI Accession #
NP_071400.1
UniProt Secondary Accession #
O94799; Q96DG7; Q9BZW6
UniProt Related Accession #
Q9H2G4
GenBank Nucleotide #
NM_022117.3
NCBI Official Full Name
testis-specific Y-encoded-like protein 2
NCBI Official Synonym Full Names
TSPY-like 2
NCBI Official Symbol
TSPYL2
NCBI Official Synonym Symbols
CDA1; CTCL; NP79; TSPX; CINAP; DENTT; SE204; HRIHFB2216
UniProt Protein Name
Testis-specific Y-encoded-like protein 2
UniProt Synonym Protein Names
Cell division autoantigen 1; Cutaneous T-cell lymphoma-associated antigen se20-4; CTCL-associated antigen se20-4; Differentially-expressed nucleolar TGF-beta1 target protein; Nuclear protein of 79 kDa; NP79
Protein Family
Testis-specific Y-encoded-like protein
UniProt Gene Name
TSPYL2
UniProt Synonym Gene Names
CDA1; DENTT; TSPX; TSPY-like protein 2; CTCL-associated antigen se20-4; NP79
UniProt Entry Name
TSYL2_HUMAN
NCBI Protein Information
testis-specific Y-encoded-like protein 2

NCBI Summary for TSPYL2

This gene encodes a member of the testis-specific protein Y-encoded, TSPY-like/SET/nucleosome assembly protein-1 superfamily. The encoded protein is localized to the nucleolus where it functions in chromatin remodeling and as an inhibitor of cell-cycle progression. This protein may play a role in the suppression of tumor growth. [provided by RefSeq, Sep 2009]
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UniProt Comments for TSPYL2

TSPYL2: Part of the CASK/TRB1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression. Belongs to the nucleosome assembly protein (NAP) family.

Protein type: Transcription regulation; DNA replication

Chromosomal Location of Human Ortholog: Xp11.2

Cellular Component: centrosome; cytoplasm; nucleolus; nucleoplasm; nucleus; plasma membrane

Molecular Function: rDNA binding

Biological Process: cell cycle; chromatin modification; negative regulation of cell cycle; negative regulation of cell growth; negative regulation of DNA replication; nucleosome assembly; regulation of protein kinase activity; regulation of signal transduction; regulation of transcription, DNA-dependent; transcription, DNA-dependent
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Research Articles on TSPYL2

1. TSPYL2 is an essential component of the REST/NRSF transcriptional complex for TGFbeta signaling activation

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-TSPYL2 antibody

 Products by Pathway  Pathway Diagram
 IRE1alpha Activates Chaperones Pathway antibodies  IRE1alpha Activates Chaperones Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Unfolded Protein Response (UPR) Pathway antibodies  Unfolded Protein Response (UPR) Pathway Diagram
 XBP1(S) Activates Chaperone Genes Pathway antibodies  XBP1(S) Activates Chaperone Genes Pathway Diagram

Diseases associated with anti-TSPYL2 antibody

 Disease Name  Pubmed Publications
 Heart Diseases Antibodies  >2 publications with TSPYL2 and Heart Diseases
 Liver Diseases Antibodies  >1 publications with TSPYL2 and Liver Diseases
 Chromosome Aberrations Antibodies  >1 publications with TSPYL2 and Chromosome Aberrations
 Prostatic Neoplasms Antibodies  >1 publications with TSPYL2 and Prostatic Neoplasms
 Hypertrophy Antibodies  >1 publications with TSPYL2 and Hypertrophy
 Cardiovascular Diseases Antibodies  >1 publications with TSPYL2 and Cardiovascular Diseases
 Kidney Diseases Antibodies  >1 publications with TSPYL2 and Kidney Diseases
 Endometrial Neoplasms Antibodies  >1 publications with TSPYL2 and Endometrial Neoplasms

Organs/Tissues associated with anti-TSPYL2 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >4 publications with TSPYL2 and Brain
 Testis Antibodies  >4 publications with TSPYL2 and Testis
 Kidney Antibodies  >1 publications with TSPYL2 and Kidney
 Connective Tissue Antibodies  >1 publications with TSPYL2 and Connective Tissue
 Uterus Antibodies  >1 publications with TSPYL2 and Uterus
 Embryonic Tissue Antibodies  >1 publications with TSPYL2 and Embryonic Tissue
 Placenta Antibodies  >1 publications with TSPYL2 and Placenta
 Prostate Antibodies  >1 publications with TSPYL2 and Prostate
 Blood Antibodies  >1 publications with TSPYL2 and Blood
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