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BPIFA1 Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS422938

MBS422938 is an antibody targeting BPIFA1. Also known as Goat anti-BPIFA1/PLUNC Antibody. Reactive in Tested: Human; Expected from sequence similarity: Human. Host: Goat. More details

$450 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
BPIFA1/PLUNC, Polyclonal Antibody
Full Product Name
Goat anti-BPIFA1/PLUNC Antibody
Product Gene Name
anti-BPIFA1 antibody
Product Synonym Gene Name
PLUNC
Product Synonym Names
BPIFA1; BPI fold containing family A, member 1; LPLUNC3; LUNX; NASG; PLUNC; SPLUNC1; SPURT; bA49G10.5; OTTHUMP00000030625; OTTHUMP00000030626; OTTHUMP00000030627; ligand-binding protein RYA3; lung-specific protein X; nasopharyngeal carcinoma-related prote; bA49G10.5 antibody; BPI fold containing family A; member 1 antibody; BPIFA1 antibody; ligand-binding protein RYA3 antibody; LPLUNC3 antibody; lung-specific protein X antibody; LUNX antibody; NASG antibody; nasopharyngeal carcinoma-related protein antibody; OTTHUMP00000030625 antibody; OTTHUMP00000030626 antibody; OTTHUMP00000030627 antibody; palate lung and nasal epithelium clone protein antibody; palate; lung and nasal epithelium associated antibody; PLUNC antibody; protein Plunc antibody; secretory protein in upper respiratory tracts antibody; SPLUNC1 antibody; SPURT antibody; tracheal epithelium enriched protein antibody; tracheal epithelium-enriched protein antibody; von Ebner protein Hl antibody; BPIFA1 / PLUNC
Immunogen Sequence
NEVLRGLDIT LVHD
Clonality
Polyclonal
Host
Goat
Species Reactivity
Tested: Human; Expected from sequence similarity: Human
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration
100ug specific antibody in 200ul (lot specific)
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
Antibody/Peptide Pairs
BPIFA1 / PLUNC peptide (MBS428455) is used for blocking the activity of BPIFA1/PLUNC antibody (MBS422938)
Molecular Weight
25,257 Da
OMIM
607412
Immunogen
Peptide with sequence C-NEVLRGLDITLVHD, from the C Terminus of the protein sequence according to NP_057667.1.
Epitope
C Terminus
Note
Reported variants represent identical protein: NP_057667.1, NP_001230122.1, NP_570913.1
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Applications Tested/Suitable for anti-BPIFA1 antibody
Peptide ELISA (EIA), Western Blot (WB)
Application Notes for anti-BPIFA1 antibody
Peptide ELISA: Antibody detection limit dilution 1: 64000.
Western Blot: Approx 26kDa band observed in secretions of Human primary airway cells in culture-and in Human Bronchoalveolar Lavage fluid (calculated MW of 26.7kDa according to NP_057667.1). Recommended concentration: 1-3ug/ml.

Western Blot (WB) of anti-BPIFA1 antibody

(2ug/ml) staining of secretions from Human primary airway cells in culture (lanes 1 and 2), and in Human Bronchoalveolar Lavage fluid (lanes 3 and 4). Data obtained from Dr. C Bingle, AURM, University of Sheffield, UK. Primary incubation was 1 hour. Detected by chemiluminescence.
Goat Anti-BPIFA1 Polyclonal Antibody – Cat# MBS422938

Other Notes

Small volumes of anti-BPIFA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for BPIFA1. It may not necessarily be applicable to this product.

NCBI GI #
7706119
NCBI GeneID
51297
NCBI Accession #
NP_057667.1
UniProt Secondary Accession #
Q9NZT0; A6XMV5; A8K9R3; E1P5M9
UniProt Related Accession #
Q9NP55
GenBank Nucleotide #
NM_016583.3
NCBI Official Full Name
BPI fold-containing family A member 1
NCBI Official Synonym Full Names
BPI fold containing family A member 1
NCBI Official Symbol
BPIFA1
NCBI Official Synonym Symbols
LUNX; NASG; PLUNC; SPURT; SPLUNC1; bA49G10.5
UniProt Protein Name
BPI fold-containing family A member 1
UniProt Synonym Protein Names
Lung-specific protein X; Nasopharyngeal carcinoma-related protein; Palate lung and nasal epithelium clone protein; Secretory protein in upper respiratory tracts; Short PLUNC1; SPLUNC1; Tracheal epithelium-enriched protein; Von Ebner protein Hl
Protein Family
BPI fold-containing family
UniProt Gene Name
BPIFA1
UniProt Synonym Gene Names
LUNX; NASG; PLUNC; SPLUNC1; SPURT; SPLUNC1
UniProt Entry Name
BPIA1_HUMAN
NCBI Protein Information
BPI fold-containing family A member 1

NCBI Summary for BPIFA1

This gene is the human homolog of murine plunc, and like the mouse gene, is specifically expressed in the upper airways and nasopharyngeal regions. The encoded antimicrobial protein displays antibacterial activity against Gram-negative bacteria. It is thought to be involved in inflammatory responses to irritants in the upper airways and may also serve as a potential molecular marker for detection of micrometastasis in non-small-cell lung cancer. Multiple transcript variants resulting from alternative splicing in the 3' UTR have been detected, but the full-length nature of only three are known. [provided by RefSeq, Aug 2014]
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UniProt Comments for BPIFA1

PLUNC: May be involved in the airway inflammatory response after exposure to irritants. May be associated with tumor progression. May play a role in innate immune responses of the upper airways. Belongs to the BPI/LBP/Plunc superfamily. Plunc family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 20q11.2

Cellular Component: extracellular region; extracellular space

Molecular Function: lipid binding; protein binding

Biological Process: antibacterial humoral response; innate immune response; multicellular organismal water homeostasis; regulation of liquid surface tension
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Research Articles on BPIFA1

1. PLUNC is a protein of the tear film and suggest that it plays a role in fluid balance and surface tension regulation at the ocular surface.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-BPIFA1 antibody

 Disease Name  Pubmed Publications
 Respiratory Tract Diseases Antibodies  >59 publications with BPIFA1 and Respiratory Tract Diseases
 Lung Diseases Antibodies  >45 publications with BPIFA1 and Lung Diseases
 Carcinoma Antibodies  >38 publications with BPIFA1 and Carcinoma
 Inflammation Antibodies  >26 publications with BPIFA1 and Inflammation
 Lung Neoplasms Antibodies  >25 publications with BPIFA1 and Lung Neoplasms
 Respiratory Tract Infections Antibodies  >24 publications with BPIFA1 and Respiratory Tract Infections
 Fibrosis Antibodies  >16 publications with BPIFA1 and Fibrosis
 Pneumonia Antibodies  >11 publications with BPIFA1 and Pneumonia
 Respiratory Hypersensitivity Antibodies  >4 publications with BPIFA1 and Respiratory Hypersensitivity
 Necrosis Antibodies  >4 publications with BPIFA1 and Necrosis

Organs/Tissues associated with anti-BPIFA1 antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >101 publications with BPIFA1 and Lung
 Pharynx Antibodies  >8 publications with BPIFA1 and Pharynx
 Trachea Antibodies  >7 publications with BPIFA1 and Trachea
 Larynx Antibodies  >3 publications with BPIFA1 and Larynx
 Connective Tissue Antibodies  >1 publications with BPIFA1 and Connective Tissue
 Muscle Antibodies  >1 publications with BPIFA1 and Muscle
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