GPX1 Antibody – Goat Polyclonal

This gene product belongs to the family of glutathione peroxidase, which functions in the detoxification of hydrogen peroxide. It contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq, Jul 2008]

GPX1: Protects the hemoglobin in erythrocytes from oxidative breakdown. Homotetramer. Interacts with MIEN1. Belongs to the glutathione peroxidase family.

Protein type: Lipid Metabolism - arachidonic acid; Other Amino Acids Metabolism - glutathione; Oxidoreductase; EC 1.11.1.9

Cellular Component: cytoplasm; mitochondrion; nucleus

Molecular Function: glutathione binding; glutathione peroxidase activity; oxidoreductase activity; peroxidase activity; phospholipid-hydroperoxide glutathione peroxidase activity; protein binding; selenium binding; SH3 domain binding

Biological Process: angiogenesis involved in wound healing; apoptosis; blood vessel endothelial cell migration; cell proliferation; cell redox homeostasis; endothelial cell development; fat cell differentiation; glutathione metabolic process; heart contraction; hydrogen peroxide catabolic process; induction of apoptosis by oxidative stress; interaction with symbiont; lipid metabolic process; myoblast proliferation; myotube differentiation; negative regulation of apoptosis; negative regulation of caspase activity; negative regulation of inflammatory response to antigenic stimulus; positive regulation of protein kinase B signaling cascade; protein amino acid oxidation; regulation of gene expression, epigenetic; regulation of mammary gland epithelial cell proliferation; regulation of neuron apoptosis; response to gamma radiation; response to hydrogen peroxide; response to hydroperoxide; response to lipid hydroperoxide; response to oxidative stress; response to reactive oxygen species; response to selenium ion; response to symbiotic bacterium; response to toxin; response to wounding; response to xenobiotic stimulus; sensory perception of sound; skeletal muscle fiber development; skeletal muscle regeneration; thermoregulation; triacylglycerol metabolic process; UV protection; vasodilation