Kallikrein 6 (KLK6) Antibody – Goat Polyclonal

This gene encodes a member of the kallikrein subfamily of the peptidase S1 family of serine proteases. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. The encoded preproprotein is proteolytically processed to generate the mature protease. Expression of this protease is regulated by steroid hormones and may be elevated in multiple human cancers and in serum from psoriasis patients. The encoded protease may participate in the cleavage of amyloid precursor protein and alpha-synuclein, thus implicating this protease in Alzheimer's and Parkinson's disease, respectively. This gene is located in a gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]

KLK6: Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis. Belongs to the peptidase S1 family. Kallikrein subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Nucleolus; EC 3.4.21.-; Secreted, signal peptide; Protease

Chromosomal Location of Human Ortholog: 19q13.3

Cellular Component: cytoplasm; endoplasmic reticulum; extracellular region; extracellular space; intercellular bridge; microtubule cytoskeleton; mitochondrion; nuclear membrane; nucleolus; nucleoplasm

Molecular Function: protein binding; serine-type endopeptidase activity

Biological Process: amyloid precursor protein metabolic process; central nervous system development; collagen catabolic process; hormone metabolic process; myelination; positive regulation of G-protein coupled receptor protein signaling pathway; protein autoprocessing; protein processing; regulation of cell differentiation; response to wounding; tissue regeneration