Dishevelled1 (DVL1) Antibody – Goat Polyclonal

The protein encoded by this gene is a member of the Dishevelled family of proteins. These proteins have an N-terminal Dishevelled/Axin domain, a Dishevelled, EGL-10, Plextrin domain, a central PDZ domain, and a C-terminal domain of approximately 200 amino acids. They regulate both canonical and non-canonical Wnt signaling as well as planar cell polarity pathways. Mice deficient for this gene are viable and fertile but display reduced social interaction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

DVL1: Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ). Belongs to the DSH family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Inhibitor

Cellular Component: axon; cell soma; clathrin-coated vesicle; cytoplasm; cytoplasmic membrane-bound vesicle; cytoplasmic vesicle; cytosol; dendrite; dendritic spine; growth cone; lateral plasma membrane; membrane; microtubule; microtubule cytoskeleton; neuron projection; plasma membrane; postsynaptic density; synapse

Molecular Function: beta-catenin binding; enzyme binding; frizzled binding; identical protein binding; protein binding; protein kinase binding; Rac GTPase binding

Biological Process: axon extension; axon guidance; axonogenesis; collateral sprouting; convergent extension involved in neural plate elongation; convergent extension involved in organogenesis; cytoplasmic microtubule organization and biogenesis; dendrite morphogenesis; multicellular organismal development; negative regulation of protein amino acid phosphorylation; negative regulation of protein binding; negative regulation of protein kinase activity; neuromuscular junction development; neurotransmitter secretion; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein amino acid phosphorylation; positive regulation of transcription, DNA-dependent; positive regulation of Wnt receptor signaling pathway; prepulse inhibition; protein stabilization; receptor clustering; regulation of neurotransmitter levels; regulation of protein amino acid phosphorylation; social behavior; synapse organization and biogenesis; transcription from RNA polymerase II promoter; Wnt receptor signaling pathway; Wnt receptor signaling pathway through beta-catenin; Wnt receptor signaling pathway, planar cell polarity pathway