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GABRA6 Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS423367

MBS423367 is an antibody targeting Gabra6. Also known as Goat anti-Gabra6 (mouse) Antibody. Reactive in Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow. Host: Goat. More details

$305 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Gabra6, Polyclonal Antibody
Full Product Name
Goat anti-Gabra6 (mouse) Antibody
Product Gene Name
anti-Gabra6 antibody
Product Synonym Names
Goat Anti-GABRA6 Antibody; Gabra6; gamma-aminobutyric acid (GABA) A receptor, subunit alpha 6; RP23-288I22.1; Gabra-6, alpha6; GABA(A) receptor subunit alpha-6; OTTMUSP00000006689; gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 6; gamma-aminobutyric acid A recptor, subuni; Gabra6 antibody; gamma-aminobutyric acid (GABA) A receptor; subunit alpha 6 antibody; RP23-288I22.1 antibody; Gabra-6; alpha6 antibody; GABA(A) receptor subunit alpha-6 antibody; OTTMUSP00000006689 antibody; gamma-aminobutyric acid (GABA-A) receptor; subunit alpha 6 antibody; gamma-aminobutyric acid A recptor; subuni antibody; Gabra6 (mouse)
Immunogen Sequence
PATGGTSKID QYSR
Clonality
Polyclonal
Host
Goat
Species Reactivity
Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration
100ug specific antibody in 200ul (lot specific)
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
Antibody/Peptide Pairs
Gabra6 peptide (MBS428613) is used for blocking the activity of Gabra6 antibody (MBS423367)
Molecular Weight
49,673 Da
Immunogen
Peptide with sequence C-PATGGTSKIDQYSR, from the internal region (near C Terminus) of the protein sequence according to NP_001093111.1; NP_032094.2.
Epitope
Internal region (near C Terminus)
Note
This antibody is expected to recognize both reported isoforms (NP_001093111.1; NP_032094.2).
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Applications Tested/Suitable for anti-Gabra6 antibody
Peptide ELISA (EIA)
Application Notes for anti-Gabra6 antibody
Peptide ELISA: Antibody detection limit dilution 1: 32000.
Western Blot: Preliminary experiments gave an approx 75kDa band in Mouse fetal Brain lysates after 1ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 49.8kDa according to NP_032094.2. The 75kDa band was successfully blocked by incubation with the immunizing peptide.

Other Notes

Small volumes of anti-Gabra6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Gabra6. It may not necessarily be applicable to this product.

NCBI GI #
153792343
NCBI GeneID
14399
NCBI Accession #
NP_001093111.1
NCBI Related Accession #
NP_032094.2
UniProt Secondary Accession #
Q5SUU5; Q9R0V3; Q9R0V4; Q9R0V5
UniProt Related Accession #
P16305
GenBank Nucleotide #
NM_001099641.2
NCBI Official Full Name
gamma-aminobutyric acid receptor subunit alpha-6 isoform 1
NCBI Official Synonym Full Names
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 6
NCBI Official Symbol
Gabra6
NCBI Official Synonym Symbols
alpha6; Gabra-6; GABA-ARalpha6
UniProt Protein Name
Gamma-aminobutyric acid receptor subunit alpha-6
UniProt Synonym Protein Names
GABA(A) receptor subunit alpha-6
Protein Family
Gamma-aminobutyric acid receptor
UniProt Gene Name
Gabra6
UniProt Synonym Gene Names
Gabra-6
UniProt Entry Name
GBRA6_MOUSE
NCBI Protein Information
gamma-aminobutyric acid receptor subunit alpha-6

UniProt Comments for Gabra6

GABRA6: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA6 sub-subfamily.

Protein type: Transporter; Membrane protein, integral; Channel, chloride; Transporter, ion channel; Membrane protein, multi-pass

Cellular Component: cell junction; dendrite; integral to membrane; integral to plasma membrane; membrane; plasma membrane; postsynaptic membrane; presynaptic membrane; receptor complex; synapse

Molecular Function: benzodiazepine receptor activity; chloride channel activity; drug binding; extracellular ligand-gated ion channel activity; GABA-A receptor activity; GABA-gated chloride ion channel activity; inhibitory extracellular ligand-gated ion channel activity; ion channel activity

Biological Process: chloride transport; gamma-aminobutyric acid signaling pathway; ion transport; protein heterooligomerization; synaptic transmission, GABAergic; transport
Show more

Research Articles on Gabra6

1. This study demonstrated that Ectopic Expression of alpha6 GABAA Receptor Subunits in Hilar Somatostatin Neurons Increases Tonic Inhibition and Alters Network Activity in the Dentate Gyrus.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-Gabra6 antibody

 Reference Product  PubMed Publications
 Gabra1 antibody  >25 publications with Gabra6 and Gabra1
 Gabrb2 antibody  >18 publications with Gabra6 and Gabrb2
 Gabra2 antibody  >8 publications with Gabra6 and Gabra2
 Gabra5 antibody  >6 publications with Gabra6 and Gabra5
 Gabra3 antibody  >4 publications with Gabra6 and Gabra3
 Gabrb1 antibody  >3 publications with Gabra6 and Gabrb1

Pathways associated with anti-Gabra6 antibody

 Products by Pathway  Pathway Diagram
 GABA A Receptor Activation Pathway antibodies  GABA A Receptor Activation Pathway Diagram
 GABA Receptor Activation Pathway antibodies  GABA Receptor Activation Pathway Diagram
 GABAergic Synapse Pathway antibodies  GABAergic Synapse Pathway Diagram
 GABAergic Synapse Pathway antibodies  GABAergic Synapse Pathway Diagram
 Ion Channel Transport Pathway antibodies  Ion Channel Transport Pathway Diagram
 Ligand-gated Ion Channel Transport Pathway antibodies  Ligand-gated Ion Channel Transport Pathway Diagram
 Morphine Addiction Pathway antibodies  Morphine Addiction Pathway Diagram
 Morphine Addiction Pathway antibodies  Morphine Addiction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram

Diseases associated with anti-Gabra6 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >20 publications with Gabra6 and Nervous System Diseases
 Brain Diseases Antibodies  >18 publications with Gabra6 and Brain Diseases
 Central Nervous System Diseases Antibodies  >15 publications with Gabra6 and Central Nervous System Diseases
 Epilepsy Antibodies  >13 publications with Gabra6 and Epilepsy
 Seizures Antibodies  >9 publications with Gabra6 and Seizures
 Anxiety Disorders Antibodies  >7 publications with Gabra6 and Anxiety Disorders
 Schizophrenia Antibodies  >4 publications with Gabra6 and Schizophrenia
 Ataxia Antibodies  >3 publications with Gabra6 and Ataxia
 Congenital Abnormalities Antibodies  >2 publications with Gabra6 and Congenital Abnormalities
 Neurobehavioral Manifestations Antibodies  >1 publications with Gabra6 and Neurobehavioral Manifestations

Organs/Tissues associated with anti-Gabra6 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >52 publications with Gabra6 and Brain
 Mixed Antibodies  >1 publications with Gabra6 and Mixed
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