ACACB Antibody – Goat Polyclonal

ACC2: a subunit of acetyl-CoA carboxylase (ACC), a multifunctional enzyme system. Catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. Activity is increased by oligomerization. Activated by citrate. Citrate and MID1IP1 promote oligomerization. Inhibited by malonyl-CoA. ACC1 is the predominant form expressed in liver, adipocyte and mammary gland. Phosphorylation by AMPK or PKA inhibits the enzymatic activity of ACC. ACC2 is the major isoform in skeletal muscle and heart. Phosphorylation regulates its activity. Two isoforms of the human protein are produced by alternative splicing.

Protein type: Mitochondrial; Lipid Metabolism - fatty acid biosynthesis; Carbohydrate Metabolism - propanoate; EC 6.4.1.2; EC 6.3.4.14; Carbohydrate Metabolism - pyruvate; Ligase

Cellular Component: membrane; mitochondrion; nucleus

Molecular Function: acetyl-CoA carboxylase activity; ATP binding; biotin binding; biotin carboxylase activity; catalytic activity; ligase activity; metal ion binding; nucleotide binding

Biological Process: acetyl-CoA metabolic process; fatty acid biosynthetic process; fatty acid metabolic process; lipid metabolic process; metabolic process; negative regulation of catalytic activity; negative regulation of fatty acid beta-oxidation; negative regulation of fatty acid oxidation; negative regulation of lipid catabolic process; protein homotetramerization; response to nutrient levels; response to organic cyclic substance