AMHR2 Antibody – Goat Polyclonal

This gene encodes the receptor for the anti-Mullerian hormone (AMH) which, in addition to testosterone, results in male sex differentiation. AMH and testosterone are produced in the testes by different cells and have different effects. Testosterone promotes the development of male genitalia while the binding of AMH to the encoded receptor prevents the development of the mullerian ducts into uterus and Fallopian tubes. Mutations in this gene are associated with persistent Mullerian duct syndrome type II. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Sep 2009]

MISR2: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.

Protein type: Protein kinase, Ser/Thr (receptor); Kinase, protein; EC 2.7.11.30; Membrane protein, integral; Protein kinase, TKL; TKL group; STKR family; Type2 subfamily

Chromosomal Location of Human Ortholog: 12q13

Cellular Component: integral to plasma membrane

Molecular Function: ATP binding; hormone binding; metal ion binding; protein binding; receptor activity; receptor signaling protein serine/threonine kinase activity; transforming growth factor beta receptor activity, type II

Biological Process: female gonad development; male gonad development; Mullerian duct regression; sex differentiation; signal transduction; transforming growth factor beta receptor signaling pathway

Disease: Persistent Mullerian Duct Syndrome, Types I And Ii