PLA2G2A Antibody – Goat Polyclonal

The protein encoded by this gene is a member of the phospholipase A2 family (PLA2). PLA2s constitute a diverse family of enzymes with respect to sequence, function, localization, and divalent cation requirements. This gene product belongs to group II, which contains secreted form of PLA2, an extracellular enzyme that has a low molecular mass and requires calcium ions for catalysis. It catalyzes the hydrolysis of the sn-2 fatty acid acyl ester bond of phosphoglycerides, releasing free fatty acids and lysophospholipids, and thought to participate in the regulation of the phospholipid metabolism in biomembranes. Several alternatively spliced transcript variants with different 5' UTRs have been found for this gene.[provided by RefSeq, Sep 2009]

PLA2G2A: Thought to participate in the regulation of the phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Belongs to the phospholipase A2 family.

Protein type: EC 3.1.1.4; Endoplasmic reticulum; Lipid Metabolism - alpha-linolenic acid; Lipid Metabolism - arachidonic acid; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Lipid Metabolism - linoleic acid; Mitochondrial; Phospholipase; Secreted; Secreted, signal peptide; Vesicle

Chromosomal Location of Human Ortholog: 1p35

Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; extracellular region; extracellular space

Molecular Function: calcium-dependent phospholipase A2 activity; phospholipase A2 activity; phospholipid binding

Biological Process: defense response to Gram-positive bacterium; phosphatidic acid biosynthetic process; phosphatidic acid metabolic process; phospholipid metabolic process; positive regulation of inflammatory response

Disease: Colorectal Cancer