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TRPV5 Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS423682

MBS423682 is an antibody targeting TRPV5. Also known as Goat Anti-TRPV5, Biotinylated Antibody. Reactive in Human, Mouse, Rat, Dog, Pig, CowTested: HumanExpected from sequence similarity: Human, Mouse, Rat, Dog, Pig, Cow. Host: Goat. More details

$450 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
TRPV5, Polyclonal Antibody
Full Product Name
Goat Anti-TRPV5, Biotinylated Antibody
Product Gene Name
anti-TRPV5 antibody
Product Synonym Names
Goat Anti-TRPV5 Antibody; TRPV5 antibody; transient receptor potential cation channel subfamily V member 5 antibody; CAT2 antibody; ECAC1 antibody; OTRPC3 antibody; calcium transport protein 2 antibody; calcium transporter 2 antibody; epithelial calcium channel 1 antibody; osm-9-like TRP channel 3 antibody; transient receptor potential cation channel, subfamily V, member 5 antibody
Immunogen Sequence
SHRGWEILRQ NT.
Clonality
Polyclonal
Host
Goat
Species Reactivity
Human, Mouse, Rat, Dog, Pig, Cow
Tested: Human
Expected from sequence similarity: Human, Mouse, Rat, Dog, Pig, Cow
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
Matching Pairs
Unconjugated Antibody: TRPV5 (MBS420745)
Biotin Conjugated Antibody: TRPV5 (MBS423682)
Antibody/Peptide Pairs
TRPV5 peptide (MBS426896) is used for blocking the activity of TRPV5 antibody (MBS423682)
Molecular Weight
43,186 Da
OMIM
606679
Immunogen
Peptide with sequence C-SHRGWEILRQNT., from the internal region of the protein sequence according to NP_062815.3.
Epitope
Internal Region
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Applications Tested/Suitable for anti-TRPV5 antibody
Peptide ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)
Application Notes for anti-TRPV5 antibody
Western Blot: Approx 82kDa band observed in Human Pancreas lysates (calculated MW of 82.6kDa according to NP_062815.2). See non-biotinylated parental product's datasheet for further QC data. Recommended concentration: 1-3ug/ml.
Peptide ELISA: Antibody detection limit dilution 1:16000.

Western Blot (WB) of anti-TRPV5 antibody

Biotinylated (2ug/ml) staining of Human Pancreas lysate (35ug protein in RIPA buffer), exactly mirroring its parental non-biotinylated product. Primary incubation was 1 hour. Detected by chemiluminescence, using streptavidin-HRP and using NAP blocker as a substitute for skimmed milk.
Goat Anti-TRPV5 Polyclonal Antibody – Cat# MBS423682

Other Notes

Small volumes of anti-TRPV5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TRPV5. It may not necessarily be applicable to this product.

NCBI GI #
730229359
NCBI GeneID
56302
NCBI Accession #
NP_062815.3
UniProt Secondary Accession #
Q8N4C1; Q8NDW5; Q8NDX7; Q8NDX8; Q96PM6; A4D2H7; E9PBZ6
UniProt Related Accession #
Q9NQA5
GenBank Nucleotide #
NM_019841.6
NCBI Official Full Name
transient receptor potential cation channel subfamily V member 5
NCBI Official Synonym Full Names
transient receptor potential cation channel subfamily V member 5
NCBI Official Symbol
TRPV5
NCBI Official Synonym Symbols
CAT2; ECAC1; OTRPC3
UniProt Protein Name
Transient receptor potential cation channel subfamily V member 5
UniProt Synonym Protein Names
Calcium transport protein 2; CaT2; Epithelial calcium channel 1; ECaC; ECaC1; Osm-9-like TRP channel 3; OTRPC3
Protein Family
Transient receptor potential cation channel subfamily
UniProt Gene Name
TRPV5
UniProt Synonym Gene Names
ECAC1; TrpV5; CaT2; ECaC; ECaC1; OTRPC3
UniProt Entry Name
TRPV5_HUMAN
NCBI Protein Information
transient receptor potential cation channel subfamily V member 5

NCBI Summary for TRPV5

This gene is a member of the transient receptor family and the TrpV subfamily. The calcium-selective channel encoded by this gene has 6 transmembrane-spanning domains, multiple potential phosphorylation sites, an N-linked glycosylation site, and 5 ANK repeats. This protein forms homotetramers or heterotetramers and is activated by a low internal calcium level. [provided by RefSeq, Jul 2008]
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UniProt Comments for TRPV5

TRPV5: Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine. The channel is activated by low internal calcium level and the current exhibits an inward rectification. A Ca(2+)- dependent feedback regulation includes fast channel inactivation and slow current decay. Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating. Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV5 sub-subfamily.

Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Membrane protein, multi-pass; Channel, cation

Chromosomal Location of Human Ortholog: 7q35

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: calcium channel activity; protein binding

Biological Process: calcium ion transport; protein tetramerization
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Research Articles on TRPV5

1. Data found that a TRPV5 polymorphism (rs4236480) was observed to be associated with stone multiplicity of calcium nephrolithiasis, as the risk of stone multiplicity was higher in patients with the TT+CT genotype than in patients with the CC genotype

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TRPV5 antibody

 Reference Product  PubMed Publications
 PTH antibody  >24 publications with TRPV5 and PTH
 CALB1 antibody  >23 publications with TRPV5 and CALB1
 TRPM7 antibody  >15 publications with TRPV5 and TRPM7
 TRPM4 antibody  >12 publications with TRPV5 and TRPM4
 LGALS1 antibody  >6 publications with TRPV5 and LGALS1
 WNK3 antibody  >3 publications with TRPV5 and WNK3
 BSPRY antibody  >2 publications with TRPV5 and BSPRY
 RAB11A antibody  >2 publications with TRPV5 and RAB11A
 FKBP4 antibody  >1 publications with TRPV5 and FKBP4

Pathways associated with anti-TRPV5 antibody

 Products by Pathway  Pathway Diagram
 Endocrine And Other Factor-regulated Calcium Reabsorption Pathway antibodies  Endocrine And Other Factor-regulated Calcium Reabsorption Pathway Diagram
 Endocrine And Other Factor-regulated Calcium Reabsorption Pathway antibodies  Endocrine And Other Factor-regulated Calcium Reabsorption Pathway Diagram
 Ion Channel Transport Pathway antibodies  Ion Channel Transport Pathway Diagram
 Osteoclast Signaling Pathway antibodies  Osteoclast Signaling Pathway Diagram
 Stimuli-sensing Channels Pathway antibodies  Stimuli-sensing Channels Pathway Diagram
 TRP Channels Pathway antibodies  TRP Channels Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram

Diseases associated with anti-TRPV5 antibody

 Disease Name  Pubmed Publications
 Hypercalciuria Antibodies  >53 publications with TRPV5 and Hypercalciuria
 Kidney Diseases Antibodies  >43 publications with TRPV5 and Kidney Diseases
 Hypertension Antibodies  >19 publications with TRPV5 and Hypertension
 Osteoporosis Antibodies  >16 publications with TRPV5 and Osteoporosis
 Hypocalcemia Antibodies  >14 publications with TRPV5 and Hypocalcemia
 Cardiovascular Diseases Antibodies  >9 publications with TRPV5 and Cardiovascular Diseases
 Pain Antibodies  >7 publications with TRPV5 and Pain
 Insulin Resistance Antibodies  >6 publications with TRPV5 and Insulin Resistance
 Renal Insufficiency Antibodies  >6 publications with TRPV5 and Renal Insufficiency
 Hyperparathyroidism, Secondary Antibodies  >4 publications with TRPV5 and Hyperparathyroidism, Secondary

Organs/Tissues associated with anti-TRPV5 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >74 publications with TRPV5 and Blood
 Lung Antibodies  >5 publications with TRPV5 and Lung
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