Mouse Anti-ADIPOQ Monoclonal Antibody – Cat# MBS4380327

Formalin-fixed, paraffin-embedded human Kidney stained with Adiponectin Monoclonal Antibody (ADPN/1370).

Adiponectin (ADIPOQ) Antibody – Mouse Monoclonal

Name: ADIPOQ Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS4380327
Price: 280 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS4380327

MBS4380327 is an antibody targeting ADIPOQ. Also known as Adiponectin (Marker of Obesity). Reactive in Human. Others not known.. Host: Mouse. More details

$280 / 0.02 mg (With BSA & Azide at 0.2mg/mL) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Adiponectin (ADIPOQ), Monoclonal Antibody

Full Product Name

Adiponectin (Marker of Obesity)

Product Gene Name

anti-ADIPOQ antibody

Product Synonym Names

Adiponectin; Adipocyte complement-related 30kDa protein (ACRP30); Adipocyte-specific secretory protein; Adiponectin, C1Q and collagen domain containing (ACDC); ADIPOQ; Adipose most abundant gene transcript 1 protein; Adipose specific collagen like factor; ADIPQTL1; ADPN; APM-1; Gelatin-binding protein 28 (GBP28)

Clonality

Monoclonal

Isotype

IgG2b

Clone Number

ADPN/1370

Host

Mouse

Species Reactivity

Human. Others not known.

Form/Format

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Specificity

This MAb reacts with adiponectin, an adipocytokine. Adipocytokines are hormones produced in adipose tissue. Adiponectin is abundantly present in plasma and has insulin like effect on glucose levels in the blood. Plasma adiponectin levels are low in insulin resistant patients who are obese, have diabetes mellitus type 2 or HIV-lipodystrophy. In women adiponectin levels tend to be higher than in men, which may be due to androgens suppressing adiponectin levels. Furthermore adiponectin and leptin are both indicated in regulating body weight through direct action on the hypothalamus, influencing appetite. Obese people have low adiponectin levels while levels in anorexia patients are high. Adiponectin acts as ligand for various receptors, two of which have been identified, one probably involved in carbohydrate assimilation, the other in tuning the rate of metabolism.

Preparation and Storage

Antibody with azide - store at 2 to 8 degree C.
Antibody without azide - store at -20 to -80 degree C.
Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Molecular Weight

26-30kDa

3D Structure

ModBase 3D Structure for Q15848

Immunogen

Recombinant human Adiponectin protein fragment

Cellular Localization

Cytoplasmic & Cell Surface

Hu-chromosome Location

3q27

Positive Control

HeLa cells or Kidney

Applications Tested/Suitable for anti-ADIPOQ antibody

ELISA (EIA), Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistochemistry (IHC) Formalin

Application Notes for anti-ADIPOQ antibody

ELISA: For coating, use antibody without BSA.
FC/FACS: 0.5-1ug/million cells
IF: 1-2ug/ml
IHC-F: 1-2ug/ml for 30 minutes at RT; Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes.

Product References and Citations for anti-ADIPOQ antibody

Dos Santos, E., et al. 2008. Adiponectin mediates an antiproliferative response in human MDA-MB 231 breast cancer cells. Oncol. Rep. 20: 971-977.

Other Notes

Small volumes of anti-ADIPOQ antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ADIPOQ. It may not necessarily be applicable to this product.

NCBI GI #

295317372

NCBI GeneID

9370

NCBI Accession #

NP_001171271.1

UniProt Primary Accession #

Q15848

UniProt Secondary Accession #

Q58EX9

UniProt Related Accession #

Q15848

GenBank Nucleotide #

NM_001177800.1

NCBI Official Full Name

adiponectin

NCBI Official Synonym Full Names

adiponectin, C1Q and collagen domain containing

NCBI Official Symbol

ADIPOQ

NCBI Official Synonym Symbols

ACDC; ADPN; APM1; APM-1; GBP28; ACRP30; ADIPQTL1

UniProt Protein Name

Adiponectin

UniProt Synonym Protein Names

30 kDa adipocyte complement-related protein; Adipocyte complement-related 30 kDa protein; ACRP30; Adipocyte, C1q and collagen domain-containing protein; Adipose most abundant gene transcript 1 protein; apM-1; Gelatin-binding protein

Protein Family

Adiponectin

UniProt Gene Name

ADIPOQ

UniProt Synonym Gene Names

ACDC; ACRP30; APM1; GBP28; ACRP30; apM-1

NCBI Protein Information

adiponectin

NCBI Summary for ADIPOQ

This gene is expressed in adipose tissue exclusively. It encodes a protein with similarity to collagens X and VIII and complement factor C1q. The encoded protein circulates in the plasma and is involved with metabolic and hormonal processes. Mutations in this gene are associated with adiponectin deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Apr 2010]

UniProt Comments for ADIPOQ

Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW.

Research Articles on ADIPOQ

1. Findings indicate that blood adiponectin concentration is more likely to be an epiphenomenon in the context of metabolic disease than a key determinant.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ADIPOQ antibody

Reference Product	PubMed Publications
PPARG antibody	>105 publications with ADIPOQ and PPARG
ADIPOR1 antibody	>95 publications with ADIPOQ and ADIPOR1
ADIPOR2 antibody	>83 publications with ADIPOQ and ADIPOR2
LEP antibody	>26 publications with ADIPOQ and LEP
FABP4 antibody	>19 publications with ADIPOQ and FABP4
INS antibody	>5 publications with ADIPOQ and INS
CEBPB antibody	>3 publications with ADIPOQ and CEBPB
WNT10B antibody	>1 publications with ADIPOQ and WNT10B

Pathways associated with anti-ADIPOQ antibody

Products by Pathway	Pathway Diagram
AMPK Signaling Pathway antibodies	AMPK Signaling Pathway Diagram
Adipocytokine Signaling Pathway antibodies	Adipocytokine Signaling Pathway Diagram
Adipocytokine Signaling Pathway antibodies	Adipocytokine Signaling Pathway Diagram
Adipogenesis Pathway antibodies	Adipogenesis Pathway Diagram
Developmental Biology Pathway antibodies	Developmental Biology Pathway Diagram
PPAR Signaling Pathway antibodies	PPAR Signaling Pathway Diagram
PPAR Signaling Pathway antibodies	PPAR Signaling Pathway Diagram
Transcriptional Regulation Of White Adipocyte Differentiation Pathway antibodies	Transcriptional Regulation Of White Adipocyte Differentiation Pathway Diagram
Type II Diabetes Mellitus Pathway antibodies	Type II Diabetes Mellitus Pathway Diagram
Type II Diabetes Mellitus Pathway antibodies	Type II Diabetes Mellitus Pathway Diagram

Diseases associated with anti-ADIPOQ antibody

Disease Name	Pubmed Publications
Insulin Resistance Antibodies	>534 publications with ADIPOQ and Insulin Resistance
Obesity Antibodies	>486 publications with ADIPOQ and Obesity
Cardiovascular Diseases Antibodies	>337 publications with ADIPOQ and Cardiovascular Diseases
Diabetes Mellitus Antibodies	>306 publications with ADIPOQ and Diabetes Mellitus
Diabetes Mellitus, Type 2 Antibodies	>221 publications with ADIPOQ and Diabetes Mellitus, Type 2
Inflammation Antibodies	>209 publications with ADIPOQ and Inflammation
Necrosis Antibodies	>167 publications with ADIPOQ and Necrosis
Heart Diseases Antibodies	>152 publications with ADIPOQ and Heart Diseases
Atherosclerosis Antibodies	>136 publications with ADIPOQ and Atherosclerosis
Metabolic Syndrome X Antibodies	>131 publications with ADIPOQ and Metabolic Syndrome X

Organs/Tissues associated with anti-ADIPOQ antibody

Organ/Tissue Name	Pubmed Publications
Adipose Tissue Antibodies	>368 publications with ADIPOQ and Adipose Tissue
Heart Antibodies	>127 publications with ADIPOQ and Heart
Kidney Antibodies	>50 publications with ADIPOQ and Kidney
Brain Antibodies	>45 publications with ADIPOQ and Brain
Intestine Antibodies	>10 publications with ADIPOQ and Intestine
Skin Antibodies	>8 publications with ADIPOQ and Skin
Nerve Antibodies	>8 publications with ADIPOQ and Nerve
Thymus Antibodies	>1 publications with ADIPOQ and Thymus
Mammary Gland Antibodies	>1 publications with ADIPOQ and Mammary Gland