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Adipophilin/Perilipin-2 (PLIN2) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS439882

MBS439882 is an antibody targeting PLIN2. Also known as Adipophilin/Perilipin-2 (Marker of Obesity). Reactive in Human. Others not known.. Host: Mouse. More details

$280 / 0.02 mg (With BSA & Azide at 0.2mg/mL) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Adipophilin/Perilipin-2 (PLIN2), Monoclonal Antibody
Full Product Name
Adipophilin/Perilipin-2 (Marker of Obesity)
Product Gene Name
anti-PLIN2 antibody
Product Synonym Names
Adipophilin; ADFP; Adipose differentiation-related protein (ADRP); Perilipin-2 (PLIN2)
Clonality
Monoclonal
Isotype
IgG2b, kappa
Clone Number
ADFP/1366
Host
Mouse
Species Reactivity
Human. Others not known.
Form/Format
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Specificity
Recognizes a protein of 48kDa, which is identified as Adipophilin. It belongs to the perilipin family, members of which coat intracellular lipid storage droplets. This protein is associated with the lipid globule surface membrane material, and maybe involved in development and maintenance of adipose tissue. However, it is not restricted to adipocytes as previously thought, but is found in a wide range of cultured cell lines, including fibroblasts, endothelial and epithelial cells, and tissues, such as lactating mammary gland, adrenal cortex, Sertoli and Leydig cells, and hepatocytes in alcoholic liver cirrhosis, suggesting that it may serve as a marker of lipid accumulation in diverse cell types and diseases.
Preparation and Storage
Antibody with azide - store at 2 to 8 degree C.
Antibody without azide - store at -20 to -80 degree C.
Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Molecular Weight
48kDa
3D Structure
ModBase 3D Structure for Q99541
Immunogen
Recombinant human Adipophilin protein fragment (aa249-376)
Cellular Localization
Cytoplasmic
Hu-chromosome Location
9p22.1
Positive Control
HepG2 or JAR cells. Liver, Adrenal gland or Cerebellum.
Applications Tested/Suitable for anti-PLIN2 antibody
ELISA (EIA), Immunofluorescence (IF), Immunohistochemistry (IHC) Formalin
Application Notes for anti-PLIN2 antibody
ELISA: For coating, order Ab without BSA.
IF: 0.5-1ug/ml
IHC-F: 0.5-1.0ug/ml for 30 minutes at RT; Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes.

Immunohistochemistry (IHC) of anti-PLIN2 antibody

Formalin-fixed, paraffin-embedded human Adrenal stained with Adipophilin Monoclonal Antibody (ADFP/1366).
Mouse Anti-PLIN2 Monoclonal Antibody – Cat# MBS439882

Immunohistochemistry (IHC) of anti-PLIN2 antibody

Formalin-fixed, paraffin-embedded human Colon Carcinoma stained with p27 Monoclonal Antibody (DCS-72.F6)
Mouse Anti-PLIN2 Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS439882

Product References and Citations for anti-PLIN2 antibody

Kern, P.A., et al. 2004. Perilipin expression in human adipose tissue is elevated with obesity. J. Clin. Endocrinol. Metab. 89: 1352-1358.

Other Notes

Small volumes of anti-PLIN2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PLIN2. It may not necessarily be applicable to this product.

NCBI GI #
34577059
NCBI GeneID
123
NCBI Accession #
NP_001113.2
UniProt Primary Accession #
Q99541
UniProt Secondary Accession #
Q9BSC3
UniProt Related Accession #
Q99541
GenBank Nucleotide #
NM_001122.3
NCBI Official Full Name
perilipin-2
NCBI Official Synonym Full Names
perilipin 2
NCBI Official Symbol
PLIN2
NCBI Official Synonym Symbols
ADFP; ADRP
UniProt Protein Name
Perilipin-2
UniProt Synonym Protein Names
Adipophilin; Adipose differentiation-related protein; ADRP
Protein Family
Perilipin
UniProt Gene Name
PLIN2
UniProt Synonym Gene Names
ADFP; ADRP
NCBI Protein Information
perilipin-2

NCBI Summary for PLIN2

The protein encoded by this gene belongs to the perilipin family, members of which coat intracellular lipid storage droplets. This protein is associated with the lipid globule surface membrane material, and maybe involved in development and maintenance of adipose tissue. However, it is not restricted to adipocytes as previously thought, but is found in a wide range of cultured cell lines, including fibroblasts, endothelial and epithelial cells, and tissues, such as lactating mammary gland, adrenal cortex, Sertoli and Leydig cells, and hepatocytes in alcoholic liver cirrhosis, suggesting that it may serve as a marker of lipid accumulation in diverse cell types and diseases. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2011]
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UniProt Comments for PLIN2

May be involved in development and maintenance of adipose tissue.

Research Articles on PLIN2

1. ADRP knockdown significantly inhibited PDGFinduced increases in Vascular smooth muscle cell viability, caused G1 phase cell cycle arrest and decreased PCNA expression.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PLIN2 antibody

 Reference Product  PubMed Publications
 PPARA antibody  >2 publications with PLIN2 and PPARA
 CARM1 antibody  >1 publications with PLIN2 and CARM1
 RXRA antibody  >1 publications with PLIN2 and RXRA

Pathways associated with anti-PLIN2 antibody

 Products by Pathway  Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies  Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
 HIF-1-alpha Transcription Factor Network Pathway antibodies  HIF-1-alpha Transcription Factor Network Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 PPARA Activates Gene Expression Pathway antibodies  PPARA Activates Gene Expression Pathway Diagram
 Regulation Of Lipid Metabolism By Peroxisome Proliferator-activated Receptor Alpha (PPARalpha) Pathway antibodies  Regulation Of Lipid Metabolism By Peroxisome Proliferator-activated Receptor Alpha (PPARalpha) Pathway Diagram

Diseases associated with anti-PLIN2 antibody

 Disease Name  Pubmed Publications
 Fatty Liver Antibodies  >12 publications with PLIN2 and Fatty Liver
 Liver Diseases Antibodies  >7 publications with PLIN2 and Liver Diseases
 Inflammation Antibodies  >5 publications with PLIN2 and Inflammation
 Kidney Diseases Antibodies  >4 publications with PLIN2 and Kidney Diseases
 Adenocarcinoma Antibodies  >3 publications with PLIN2 and Adenocarcinoma
 Atrophy Antibodies  >2 publications with PLIN2 and Atrophy
 Breast Neoplasms Antibodies  >2 publications with PLIN2 and Breast Neoplasms
 Cardiovascular Diseases Antibodies  >2 publications with PLIN2 and Cardiovascular Diseases
 Fibrosis Antibodies  >1 publications with PLIN2 and Fibrosis
 Weight Loss Antibodies  >1 publications with PLIN2 and Weight Loss

Organs/Tissues associated with anti-PLIN2 antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >21 publications with PLIN2 and Muscle
 Liver Antibodies  >14 publications with PLIN2 and Liver
 Blood Antibodies  >12 publications with PLIN2 and Blood
 Adipose Tissue Antibodies  >12 publications with PLIN2 and Adipose Tissue
 Mammary Gland Antibodies  >5 publications with PLIN2 and Mammary Gland
 Bone Antibodies  >5 publications with PLIN2 and Bone
 Connective Tissue Antibodies  >4 publications with PLIN2 and Connective Tissue
 Kidney Antibodies  >4 publications with PLIN2 and Kidney
 Heart Antibodies  >2 publications with PLIN2 and Heart
 Skin Antibodies  >2 publications with PLIN2 and Skin
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