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FSH-Receptor (FSHR) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS439978

MBS439978 is an antibody targeting FSHR. Also known as FSH-Receptor (Ovarian Marker). Reactive in Human. Host: Mouse. More details

$280 / 0.02 mg (With BSA & Azide at 0.2mg/mL) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
FSH-Receptor (FSHR), Monoclonal Antibody
Full Product Name
FSH-Receptor (Ovarian Marker)
Product Gene Name
anti-FSHR antibody
Product Synonym Names
Follicle-stimulating hormone receptor; Follitropin receptor; FSH receptor; FSH-R; FSHRO; LGR1; ODG1; ovarian dysgenesis 1
Clonality
Monoclonal
Isotype
IgG1, kappa
Clone Number
FSHR/1400
Host
Mouse
Species Reactivity
Human
Form/Format
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Specificity
Follicle-stimulating hormone receptor (FSHR) is a 695 amino acid G protein coupled receptor. FSH binds to the receptor in a hand-clasp fashion via its alpha and beta subunits. While the alpha subunit of FSH is involved in the binding of FSH to the receptor, the beta subunit stabilizes this interaction. Linkage studies suggest that a missense mutation in the FSHR gene can cause reduced FSH binding affinity and lead to a condition known as hypergonadotropic ovarian dysgenesis (ODG). In males however, this mutation does not appear to have a detrimental affect on fertility. It is believed that a mutation in the FSHR gene is also associated with ovarian hyperstimulation syndrome; a condition characterized by the presence of multiple serous and hemorrhagic follicular cysts lined by luteinized cells.
Preparation and Storage
Antibody with azide - store at 2 to 8 degree C.
Non-hazardous. No MSDS required.
Molecular Weight
75kDa
3D Structure
ModBase 3D Structure for P23945
Immunogen
Recombinant human full-length FSHR protein
Cellular Localization
Cytoplasmic & Cell Surface
Hu-chromosome Location
2p21-p16
Positive Control
Uterine Carcinoma
Applications Tested/Suitable for anti-FSHR antibody
Flow Cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC) Formalin
Application Notes for anti-FSHR antibody
Immunohistochemistry (Formalin-fixed) (0.1-0.2ug/ml for 30 min at RT) (Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined

Immunohistochemistry (IHC) of anti-FSHR antibody

Formalin-fixed, paraffin-embedded human Uterine Carcinoma stained with FSH Receptor Monoclonal Antibody (FSHR/1400).
Mouse Anti-FSHR Monoclonal Antibody – Cat# MBS439978

Immunohistochemistry (IHC) of anti-FSHR antibody

Formalin-fixed, paraffin-embedded human Breast Invasive Ductal Carcinoma stained with Estrogen Receptor Monoclonal Antibody (ER506).
Mouse Anti-FSHR Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS439978

SDS-PAGE of anti-FSHR antibody

SDS-PAGE Analysis Purified FSH Receptor Mouse Monoclonal Antibody (FSHR/1400). Confirmation of Purity and Integrity of Antibody.
Mouse Anti-FSHR Monoclonal Antibody, SDS-PAGE – Cat# MBS439978

Product References and Citations for anti-FSHR antibody

Beau, I., et al. 1998. The basolateral localization signal of the follicle-stimulating hormone receptor. J. Biol. Chem. 273: 18610-18616.

Other Notes

Small volumes of anti-FSHR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for FSHR. It may not necessarily be applicable to this product.

NCBI GI #
31657138
NCBI GeneID
2492
NCBI Accession #
NP_000136.2
UniProt Primary Accession #
P23945
UniProt Secondary Accession #
Q05AH0; Q16225; Q4QRJ3; Q4ZFZ2; Q53RW2; A0A0A0MSC5; A8K947; G5CBS7; G5E967; J3KQ00
UniProt Related Accession #
P23945
GenBank Nucleotide #
NM_000145.3
NCBI Official Full Name
follicle-stimulating hormone receptor isoform 1
NCBI Official Synonym Full Names
follicle stimulating hormone receptor
NCBI Official Symbol
FSHR
NCBI Official Synonym Symbols
LGR1; ODG1; FSHR1; FSHRO
UniProt Protein Name
Follicle-stimulating hormone receptor
UniProt Synonym Protein Names
Follitropin receptor
Protein Family
Follicle-stimulating hormone receptor
UniProt Gene Name
FSHR
UniProt Synonym Gene Names
LGR1; FSH-R
NCBI Protein Information
follicle-stimulating hormone receptor

NCBI Summary for FSHR

The protein encoded by this gene belongs to family 1 of G-protein coupled receptors. It is the receptor for follicle stimulating hormone and functions in gonad development. Mutations in this gene cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
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UniProt Comments for FSHR

G protein-coupled receptor for follitropin, the follicle-stimulating hormone (PubMed:11847099, PubMed:24058690, PubMed:24692546). Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways (PubMed:24058690).

Research Articles on FSHR

1. Findings suggest that 680Ser-Ser/GG genotype and "GG/307Ala680Ser" haplotype increase the risk of endometriosis in fertile women, while "GA/307Ala680Asn" haplotype decreases the risk of endometriosis development and progression.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-FSHR antibody

 Reference Product  PubMed Publications
 FSHB antibody  >16 publications with FSHR and FSHB
 APPL1 antibody  >4 publications with FSHR and APPL1
 GRK4 antibody  >1 publications with FSHR and GRK4
 AKT2 antibody  >1 publications with FSHR and AKT2

Pathways associated with anti-FSHR antibody

 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 FSH Signaling Pathway antibodies  FSH Signaling Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 GPCRs, Other Pathway antibodies  GPCRs, Other Pathway Diagram
 Hormone Ligand-binding Receptors Pathway antibodies  Hormone Ligand-binding Receptors Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram

Diseases associated with anti-FSHR antibody

 Disease Name  Pubmed Publications
 Genital Diseases, Female Antibodies  >113 publications with FSHR and Genital Diseases, Female
 Ovarian Diseases Antibodies  >89 publications with FSHR and Ovarian Diseases
 Infertility, Female Antibodies  >62 publications with FSHR and Infertility, Female
 Neoplasms Antibodies  >59 publications with FSHR and Neoplasms
 Infertility, Male Antibodies  >44 publications with FSHR and Infertility, Male
 Genital Diseases, Male Antibodies  >38 publications with FSHR and Genital Diseases, Male
 Polycystic Ovary Syndrome Antibodies  >26 publications with FSHR and Polycystic Ovary Syndrome
 Ovarian Hyperstimulation Syndrome Antibodies  >25 publications with FSHR and Ovarian Hyperstimulation Syndrome
 Drug Toxicity Antibodies  >12 publications with FSHR and Drug Toxicity
 Disorders of Sex Development Antibodies  >11 publications with FSHR and Disorders of Sex Development

Organs/Tissues associated with anti-FSHR antibody

 Organ/Tissue Name  Pubmed Publications
 Testis Antibodies  >119 publications with FSHR and Testis
 Mixed Antibodies  >1 publications with FSHR and Mixed
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